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Biodiversity of secondary metabolites compounds isolated from phylum actinobacteria and its therapeutic applications

The current review aims to summarise the biodiversity and biosynthesis of novel secondary metabolites compounds, of the phylum Actinobacteria and the diverse range of secondary metabolites produced that vary depending on its ecological environments they inhabit. Actinobacteria creates a wide range o...

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Main Authors:	Al-shaibani, M. M., Radin Mohamed, R. M. S., Sidik, N. M., El Enshasy, H. A., Al-Gheethi, A., Noman, E., Al-Mekhlafi, N. A., Mohamad Zin, N.
Format:	Article
Published:	MDPI AG 2021
Subjects:	Q Science (General)
Online Access:	http://eprints.utm.my/id/eprint/94667/ http://dx.doi.org/10.3390/molecules26154504
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id	my.utm.94667
record_format	eprints
spelling	my.utm.946672022-03-31T15:13:42Z http://eprints.utm.my/id/eprint/94667/ Biodiversity of secondary metabolites compounds isolated from phylum actinobacteria and its therapeutic applications Al-shaibani, M. M. Radin Mohamed, R. M. S. Sidik, N. M. El Enshasy, H. A. Al-Gheethi, A. Noman, E. Al-Mekhlafi, N. A. Mohamad Zin, N. Q Science (General) The current review aims to summarise the biodiversity and biosynthesis of novel secondary metabolites compounds, of the phylum Actinobacteria and the diverse range of secondary metabolites produced that vary depending on its ecological environments they inhabit. Actinobacteria creates a wide range of bioactive substances that can be of great value to public health and the pharmaceutical industry. The literature analysis process for this review was conducted using the VOSviewer software tool to visualise the bibliometric networks of the most relevant databases from the Scopus database in the period between 2010 and 22 March 2021. Screening and exploring the available literature relating to the extreme environments and ecosystems that Actinobacteria inhabit aims to identify new strains of this major microorganism class, producing unique novel bioactive compounds. The knowledge gained from these studies is intended to encourage scientists in the natural product discovery field to identify and characterise novel strains containing various bioac-tive gene clusters with potential clinical applications. It is evident that Actinobacteria adapted to survive in extreme environments represent an important source of a wide range of bioactive com-pounds. Actinobacteria have a large number of secondary metabolite biosynthetic gene clusters. They can synthesise thousands of subordinate metabolites with different biological actions such as anti-bacterial, anti-parasitic, anti-fungal, anti-virus, anti-cancer and growth-promoting compounds. These are highly significant economically due to their potential applications in the food, nutrition and health industries and thus support our communities’ well-being. MDPI AG 2021 Article PeerReviewed Al-shaibani, M. M. and Radin Mohamed, R. M. S. and Sidik, N. M. and El Enshasy, H. A. and Al-Gheethi, A. and Noman, E. and Al-Mekhlafi, N. A. and Mohamad Zin, N. (2021) Biodiversity of secondary metabolites compounds isolated from phylum actinobacteria and its therapeutic applications. Molecules, 26 (15). ISSN 1420-3049 http://dx.doi.org/10.3390/molecules26154504 DOI: 10.3390/molecules26154504
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
topic	Q Science (General)
spellingShingle	Q Science (General) Al-shaibani, M. M. Radin Mohamed, R. M. S. Sidik, N. M. El Enshasy, H. A. Al-Gheethi, A. Noman, E. Al-Mekhlafi, N. A. Mohamad Zin, N. Biodiversity of secondary metabolites compounds isolated from phylum actinobacteria and its therapeutic applications
description	The current review aims to summarise the biodiversity and biosynthesis of novel secondary metabolites compounds, of the phylum Actinobacteria and the diverse range of secondary metabolites produced that vary depending on its ecological environments they inhabit. Actinobacteria creates a wide range of bioactive substances that can be of great value to public health and the pharmaceutical industry. The literature analysis process for this review was conducted using the VOSviewer software tool to visualise the bibliometric networks of the most relevant databases from the Scopus database in the period between 2010 and 22 March 2021. Screening and exploring the available literature relating to the extreme environments and ecosystems that Actinobacteria inhabit aims to identify new strains of this major microorganism class, producing unique novel bioactive compounds. The knowledge gained from these studies is intended to encourage scientists in the natural product discovery field to identify and characterise novel strains containing various bioac-tive gene clusters with potential clinical applications. It is evident that Actinobacteria adapted to survive in extreme environments represent an important source of a wide range of bioactive com-pounds. Actinobacteria have a large number of secondary metabolite biosynthetic gene clusters. They can synthesise thousands of subordinate metabolites with different biological actions such as anti-bacterial, anti-parasitic, anti-fungal, anti-virus, anti-cancer and growth-promoting compounds. These are highly significant economically due to their potential applications in the food, nutrition and health industries and thus support our communities’ well-being.
format	Article
author	Al-shaibani, M. M. Radin Mohamed, R. M. S. Sidik, N. M. El Enshasy, H. A. Al-Gheethi, A. Noman, E. Al-Mekhlafi, N. A. Mohamad Zin, N.
author_facet	Al-shaibani, M. M. Radin Mohamed, R. M. S. Sidik, N. M. El Enshasy, H. A. Al-Gheethi, A. Noman, E. Al-Mekhlafi, N. A. Mohamad Zin, N.
author_sort	Al-shaibani, M. M.
title	Biodiversity of secondary metabolites compounds isolated from phylum actinobacteria and its therapeutic applications
title_short	Biodiversity of secondary metabolites compounds isolated from phylum actinobacteria and its therapeutic applications
title_full	Biodiversity of secondary metabolites compounds isolated from phylum actinobacteria and its therapeutic applications
title_fullStr	Biodiversity of secondary metabolites compounds isolated from phylum actinobacteria and its therapeutic applications
title_full_unstemmed	Biodiversity of secondary metabolites compounds isolated from phylum actinobacteria and its therapeutic applications
title_sort	biodiversity of secondary metabolites compounds isolated from phylum actinobacteria and its therapeutic applications
publisher	MDPI AG
publishDate	2021
url	http://eprints.utm.my/id/eprint/94667/ http://dx.doi.org/10.3390/molecules26154504
_version_	1729703204457807872
score	13.211869

Biodiversity of secondary metabolites compounds isolated from phylum actinobacteria and its therapeutic applications

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