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Biomimetic scaffolds with programmable pore structures for minimum invasive bone repair

Due to the complexity of surgery for large-area bone injuries, implanting a large volume of materials into the injury site remains a big challenge in orthopedics. To solve this difficulty, in this study, a series of biomimetic hydroxyapatite/shape-memory composite scaffolds were designed and synthes...

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Main Authors:	Wang, Li, Zeng, Xiyang, Yan, Guilong, Chen, Xiaohu, Luo, Kun, Zhou, Shiyi, Zhang, Peicong, Li, Junfeng, Wong, Tuck Whye
Format:	Article
Published:	Royal Society of Chemistry 2021
Subjects:	TP Chemical technology
Online Access:	http://eprints.utm.my/id/eprint/94316/ http://dx.doi.org/10.1039/d1nr04124j
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id	my.utm.94316
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spelling	my.utm.943162022-03-31T15:30:12Z http://eprints.utm.my/id/eprint/94316/ Biomimetic scaffolds with programmable pore structures for minimum invasive bone repair Wang, Li Zeng, Xiyang Yan, Guilong Chen, Xiaohu Luo, Kun Zhou, Shiyi Zhang, Peicong Li, Junfeng Wong, Tuck Whye TP Chemical technology Due to the complexity of surgery for large-area bone injuries, implanting a large volume of materials into the injury site remains a big challenge in orthopedics. To solve this difficulty, in this study, a series of biomimetic hydroxyapatite/shape-memory composite scaffolds were designed and synthesized with programmable pore structures, based on poly(ϵ-caprolactone) (PCL), polytetrahydrofuran (PTMG) and the osteoconductive hydroxyapatite (HA). The obtained scaffolds presented various pore structures, high connectivity, tunable mechanical properties, and excellent shape memory performance. Moreover, the mineralization activity of the developed scaffolds could enhance the formation of hydroxyapatite and they showed good biocompatibility in vitro. The in vivo experiments show that scaffolds could promote the formation of new bone in critical size cranial defects. The programmable porous scaffold biomaterials exhibited potential application promise in bone regeneration. Royal Society of Chemistry 2021-10 Article PeerReviewed Wang, Li and Zeng, Xiyang and Yan, Guilong and Chen, Xiaohu and Luo, Kun and Zhou, Shiyi and Zhang, Peicong and Li, Junfeng and Wong, Tuck Whye (2021) Biomimetic scaffolds with programmable pore structures for minimum invasive bone repair. Nanoscale, 13 (39). pp. 16680-16689. ISSN 2040-3364 http://dx.doi.org/10.1039/d1nr04124j DOI:10.1039/d1nr04124j
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
topic	TP Chemical technology
spellingShingle	TP Chemical technology Wang, Li Zeng, Xiyang Yan, Guilong Chen, Xiaohu Luo, Kun Zhou, Shiyi Zhang, Peicong Li, Junfeng Wong, Tuck Whye Biomimetic scaffolds with programmable pore structures for minimum invasive bone repair
description	Due to the complexity of surgery for large-area bone injuries, implanting a large volume of materials into the injury site remains a big challenge in orthopedics. To solve this difficulty, in this study, a series of biomimetic hydroxyapatite/shape-memory composite scaffolds were designed and synthesized with programmable pore structures, based on poly(ϵ-caprolactone) (PCL), polytetrahydrofuran (PTMG) and the osteoconductive hydroxyapatite (HA). The obtained scaffolds presented various pore structures, high connectivity, tunable mechanical properties, and excellent shape memory performance. Moreover, the mineralization activity of the developed scaffolds could enhance the formation of hydroxyapatite and they showed good biocompatibility in vitro. The in vivo experiments show that scaffolds could promote the formation of new bone in critical size cranial defects. The programmable porous scaffold biomaterials exhibited potential application promise in bone regeneration.
format	Article
author	Wang, Li Zeng, Xiyang Yan, Guilong Chen, Xiaohu Luo, Kun Zhou, Shiyi Zhang, Peicong Li, Junfeng Wong, Tuck Whye
author_facet	Wang, Li Zeng, Xiyang Yan, Guilong Chen, Xiaohu Luo, Kun Zhou, Shiyi Zhang, Peicong Li, Junfeng Wong, Tuck Whye
author_sort	Wang, Li
title	Biomimetic scaffolds with programmable pore structures for minimum invasive bone repair
title_short	Biomimetic scaffolds with programmable pore structures for minimum invasive bone repair
title_full	Biomimetic scaffolds with programmable pore structures for minimum invasive bone repair
title_fullStr	Biomimetic scaffolds with programmable pore structures for minimum invasive bone repair
title_full_unstemmed	Biomimetic scaffolds with programmable pore structures for minimum invasive bone repair
title_sort	biomimetic scaffolds with programmable pore structures for minimum invasive bone repair
publisher	Royal Society of Chemistry
publishDate	2021
url	http://eprints.utm.my/id/eprint/94316/ http://dx.doi.org/10.1039/d1nr04124j
_version_	1729703154872745984
score	13.211869

Biomimetic scaffolds with programmable pore structures for minimum invasive bone repair

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