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CNT and rGO reinforced PMMA based bone cement for fixation of load bearing implants: mechanical property and biological response

Polymethyl methacrylate (PMMA) bone cements (BCs) have some drawbacks, including limited bioactivity and bone formation, as well as inferior mechanical properties, which may result in failure of the BC. To deal with the mentioned issues, novel bioactive polymethyl methacrylate-hardystonite (PMMA-HT)...

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Main Authors: Pahlevanzadeh, F., Bakhsheshi-Rad, H. R., Kharaziha, M., Kasiri-Asgarani, M., Omidi, M., Razzaghi, M., Ismail, Ahmad Fauzi, Sharif, Safian, Krishna, Seeram Rama, Berto, F.
Format: Article
Published: Elsevier Ltd 2021
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TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/94268/
http://dx.doi.org/10.1016/j.jmbbm.2021.104320
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spelling my.utm.942682022-03-31T15:25:20Z http://eprints.utm.my/id/eprint/94268/ CNT and rGO reinforced PMMA based bone cement for fixation of load bearing implants: mechanical property and biological response Pahlevanzadeh, F. Bakhsheshi-Rad, H. R. Kharaziha, M. Kasiri-Asgarani, M. Omidi, M. Razzaghi, M. Ismail, Ahmad Fauzi Sharif, Safian Krishna, Seeram Rama Berto, F. TP Chemical technology Polymethyl methacrylate (PMMA) bone cements (BCs) have some drawbacks, including limited bioactivity and bone formation, as well as inferior mechanical properties, which may result in failure of the BC. To deal with the mentioned issues, novel bioactive polymethyl methacrylate-hardystonite (PMMA-HT) bone cement (BC) reinforced with 0.25 and 0.5 wt% of carbon nanotube (CNT) and reduced graphene oxide (rGO) was synthesized. In this context, the obtained bone cements were evaluated in terms of their mechanical and biological characteristics. The rGO reinforced bone cement exhibited better mechanical properties to the extent that the addition of 0.5 wt% of rGO where its compressive and tensile strength of bioactive PMMA-HT/rGO cement escalated from 92.07 ± 0.72 MPa, and 40.02 ± 0.71 MPa to 187.48 ± 5.79 MPa and 64.92 ± 0.75 MPa, respectively. Besides, the mechanisms of toughening, apatite formation, and cell interaction in CNT and rGO encapsulated PMMA have been studied. Results showed that the existence of CNT and rGO in BCs led to increase of MG63 osteoblast viability, and proliferation. However, rGO reinforced bone cement was more successful in supporting MG63 cell attachment compared to the CNT counterpart due to its wrinkled surface, which made a suitable substrate for cell adhesion. Based on the results, PMMA-HT/rGO can be a proper bone cement for the fixation of load-bearing implants. Elsevier Ltd 2021-04 Article PeerReviewed Pahlevanzadeh, F. and Bakhsheshi-Rad, H. R. and Kharaziha, M. and Kasiri-Asgarani, M. and Omidi, M. and Razzaghi, M. and Ismail, Ahmad Fauzi and Sharif, Safian and Krishna, Seeram Rama and Berto, F. (2021) CNT and rGO reinforced PMMA based bone cement for fixation of load bearing implants: mechanical property and biological response. Journal of the Mechanical Behavior of Biomedical Materials, 116 . ISSN 1751-6161 http://dx.doi.org/10.1016/j.jmbbm.2021.104320 DOI:10.1016/j.jmbbm.2021.104320
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic TP Chemical technology
spellingShingle TP Chemical technology
Pahlevanzadeh, F.
Bakhsheshi-Rad, H. R.
Kharaziha, M.
Kasiri-Asgarani, M.
Omidi, M.
Razzaghi, M.
Ismail, Ahmad Fauzi
Sharif, Safian
Krishna, Seeram Rama
Berto, F.
CNT and rGO reinforced PMMA based bone cement for fixation of load bearing implants: mechanical property and biological response
description Polymethyl methacrylate (PMMA) bone cements (BCs) have some drawbacks, including limited bioactivity and bone formation, as well as inferior mechanical properties, which may result in failure of the BC. To deal with the mentioned issues, novel bioactive polymethyl methacrylate-hardystonite (PMMA-HT) bone cement (BC) reinforced with 0.25 and 0.5 wt% of carbon nanotube (CNT) and reduced graphene oxide (rGO) was synthesized. In this context, the obtained bone cements were evaluated in terms of their mechanical and biological characteristics. The rGO reinforced bone cement exhibited better mechanical properties to the extent that the addition of 0.5 wt% of rGO where its compressive and tensile strength of bioactive PMMA-HT/rGO cement escalated from 92.07 ± 0.72 MPa, and 40.02 ± 0.71 MPa to 187.48 ± 5.79 MPa and 64.92 ± 0.75 MPa, respectively. Besides, the mechanisms of toughening, apatite formation, and cell interaction in CNT and rGO encapsulated PMMA have been studied. Results showed that the existence of CNT and rGO in BCs led to increase of MG63 osteoblast viability, and proliferation. However, rGO reinforced bone cement was more successful in supporting MG63 cell attachment compared to the CNT counterpart due to its wrinkled surface, which made a suitable substrate for cell adhesion. Based on the results, PMMA-HT/rGO can be a proper bone cement for the fixation of load-bearing implants.
format Article
author Pahlevanzadeh, F.
Bakhsheshi-Rad, H. R.
Kharaziha, M.
Kasiri-Asgarani, M.
Omidi, M.
Razzaghi, M.
Ismail, Ahmad Fauzi
Sharif, Safian
Krishna, Seeram Rama
Berto, F.
author_facet Pahlevanzadeh, F.
Bakhsheshi-Rad, H. R.
Kharaziha, M.
Kasiri-Asgarani, M.
Omidi, M.
Razzaghi, M.
Ismail, Ahmad Fauzi
Sharif, Safian
Krishna, Seeram Rama
Berto, F.
author_sort Pahlevanzadeh, F.
title CNT and rGO reinforced PMMA based bone cement for fixation of load bearing implants: mechanical property and biological response
title_short CNT and rGO reinforced PMMA based bone cement for fixation of load bearing implants: mechanical property and biological response
title_full CNT and rGO reinforced PMMA based bone cement for fixation of load bearing implants: mechanical property and biological response
title_fullStr CNT and rGO reinforced PMMA based bone cement for fixation of load bearing implants: mechanical property and biological response
title_full_unstemmed CNT and rGO reinforced PMMA based bone cement for fixation of load bearing implants: mechanical property and biological response
title_sort cnt and rgo reinforced pmma based bone cement for fixation of load bearing implants: mechanical property and biological response
publisher Elsevier Ltd
publishDate 2021
url http://eprints.utm.my/id/eprint/94268/
http://dx.doi.org/10.1016/j.jmbbm.2021.104320
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score 13.211869

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