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Nano and microparticles as potential oral vaccine carriers and adjuvants against infectious diseases

Mucosal surfaces are the first site of infection for most infectious diseases and oral vaccination can provide protection as the first line of defense. Unlike systemic administration, oral immunization can stimulate cellular and humoral immune responses at both systemic and mucosal levels to induce...

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Main Authors: Jazayeri, S. D., Lim, H. X., Shameli, K., Yeap, S. K., Poh, C. L.
Format: Article
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
T Technology (General)
Online Access:http://eprints.utm.my/id/eprint/94259/1/KamyarShameli2021_NanoandMicroparticlesasPotential.pdf
http://eprints.utm.my/id/eprint/94259/
http://dx.doi.org/10.3389/fphar.2021.68228
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spelling my.utm.942592022-03-31T14:45:05Z http://eprints.utm.my/id/eprint/94259/ Nano and microparticles as potential oral vaccine carriers and adjuvants against infectious diseases Jazayeri, S. D. Lim, H. X. Shameli, K. Yeap, S. K. Poh, C. L. T Technology (General) Mucosal surfaces are the first site of infection for most infectious diseases and oral vaccination can provide protection as the first line of defense. Unlike systemic administration, oral immunization can stimulate cellular and humoral immune responses at both systemic and mucosal levels to induce broad-spectrum and long-lasting immunity. Therefore, to design a successful vaccine, it is essential to stimulate the mucosal as well as systemic immune responses. Successful oral vaccines need to overcome the harsh gastrointestinal environment such as the extremely low pH, proteolytic enzymes, bile salts as well as low permeability and the low immunogenicity of vaccines. In recent years, several delivery systems and adjuvants have been developed for improving oral vaccine delivery and immunogenicity. Formulation of vaccines with nanoparticles and microparticles have been shown to improve antigen stability, availability and adjuvanticity as well as immunostimulatory capacity, target delivery and specific release. This review discusses how nanoparticles (NPs) and microparticles (MPs) as oral carriers with adjuvant characteristics can be beneficial in oral vaccine development. Frontiers Media S.A. 2021-06 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/94259/1/KamyarShameli2021_NanoandMicroparticlesasPotential.pdf Jazayeri, S. D. and Lim, H. X. and Shameli, K. and Yeap, S. K. and Poh, C. L. (2021) Nano and microparticles as potential oral vaccine carriers and adjuvants against infectious diseases. Frontiers in Pharmacology, 12 . ISSN 1663-9812 http://dx.doi.org/10.3389/fphar.2021.68228 DOI: 10.3389/fphar.2021.68228
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic T Technology (General)
spellingShingle T Technology (General)
Jazayeri, S. D.
Lim, H. X.
Shameli, K.
Yeap, S. K.
Poh, C. L.
Nano and microparticles as potential oral vaccine carriers and adjuvants against infectious diseases
description Mucosal surfaces are the first site of infection for most infectious diseases and oral vaccination can provide protection as the first line of defense. Unlike systemic administration, oral immunization can stimulate cellular and humoral immune responses at both systemic and mucosal levels to induce broad-spectrum and long-lasting immunity. Therefore, to design a successful vaccine, it is essential to stimulate the mucosal as well as systemic immune responses. Successful oral vaccines need to overcome the harsh gastrointestinal environment such as the extremely low pH, proteolytic enzymes, bile salts as well as low permeability and the low immunogenicity of vaccines. In recent years, several delivery systems and adjuvants have been developed for improving oral vaccine delivery and immunogenicity. Formulation of vaccines with nanoparticles and microparticles have been shown to improve antigen stability, availability and adjuvanticity as well as immunostimulatory capacity, target delivery and specific release. This review discusses how nanoparticles (NPs) and microparticles (MPs) as oral carriers with adjuvant characteristics can be beneficial in oral vaccine development.
format Article
author Jazayeri, S. D.
Lim, H. X.
Shameli, K.
Yeap, S. K.
Poh, C. L.
author_facet Jazayeri, S. D.
Lim, H. X.
Shameli, K.
Yeap, S. K.
Poh, C. L.
author_sort Jazayeri, S. D.
title Nano and microparticles as potential oral vaccine carriers and adjuvants against infectious diseases
title_short Nano and microparticles as potential oral vaccine carriers and adjuvants against infectious diseases
title_full Nano and microparticles as potential oral vaccine carriers and adjuvants against infectious diseases
title_fullStr Nano and microparticles as potential oral vaccine carriers and adjuvants against infectious diseases
title_full_unstemmed Nano and microparticles as potential oral vaccine carriers and adjuvants against infectious diseases
title_sort nano and microparticles as potential oral vaccine carriers and adjuvants against infectious diseases
publisher Frontiers Media S.A.
publishDate 2021
url http://eprints.utm.my/id/eprint/94259/1/KamyarShameli2021_NanoandMicroparticlesasPotential.pdf
http://eprints.utm.my/id/eprint/94259/
http://dx.doi.org/10.3389/fphar.2021.68228
_version_ 1729703146736844800
score 13.211869

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