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Electrochemical degradation of metoprolol using graphite-pvc composite as anode: elucidation and characterization of new by-products using LC-TOF/MS

Metoprolol (MTP) is one of pharmaceuticals used for treatment of heart failure and hypertension. It was frequently detected in wastewater samples either influent or effluent. The application of graphite-PVC composite as anode was investigated for the degradation of metoprolol in the presence of stro...

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Main Authors: Mussa, Z. H., Al-Qaim, F. F., Yuzir, A., Shameli, K.
Format: Article
Published: Sociedad Quimica de Mexico A.C. 2020
Subjects:
T Technology (General)
Online Access:http://eprints.utm.my/id/eprint/93652/
http://dx.doi.org/10.29356/jmcs.v64i3.1139
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spelling my.utm.936522021-12-31T08:28:23Z http://eprints.utm.my/id/eprint/93652/ Electrochemical degradation of metoprolol using graphite-pvc composite as anode: elucidation and characterization of new by-products using LC-TOF/MS Mussa, Z. H. Al-Qaim, F. F. Yuzir, A. Shameli, K. T Technology (General) Metoprolol (MTP) is one of pharmaceuticals used for treatment of heart failure and hypertension. It was frequently detected in wastewater samples either influent or effluent. The application of graphite-PVC composite as anode was investigated for the degradation of metoprolol in the presence of strong electrolyte such as sodium chloride (NaCl). The degradation rate was strongly influenced by initial concentrations of metoprolol, NaCl concentration and applied voltage. An initial concentration of 2 mg/L was eliminated more than 95% after 30 min under optimum conditions; 5000 mg/L NaCl and 5 V. The consumption energy of the electrochemical reaction was 0.665 Wh/mg for metoprolol after 30 min. The kinetic rate constant of metoprolol could be ranged between 0.0016 and 0.0801 min-1. The electrochemical degradation efficiency of metoprolol and its by-products has been achieved. The degradation of metoprolol produced four transformated products as investigated and elucidated using liquid chromatography-time of flight/mass spectrometry. The proposed degradation pathway of metoprolol was schemed on the base of the identified intermediates. Sociedad Quimica de Mexico A.C. 2020 Article PeerReviewed Mussa, Z. H. and Al-Qaim, F. F. and Yuzir, A. and Shameli, K. (2020) Electrochemical degradation of metoprolol using graphite-pvc composite as anode: elucidation and characterization of new by-products using LC-TOF/MS. Journal of the Mexican Chemical Society, 64 (3). pp. 165-180. ISSN 1870-249X http://dx.doi.org/10.29356/jmcs.v64i3.1139 DOI: 10.29356/jmcs.v64i3.1139
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic T Technology (General)
spellingShingle T Technology (General)
Mussa, Z. H.
Al-Qaim, F. F.
Yuzir, A.
Shameli, K.
Electrochemical degradation of metoprolol using graphite-pvc composite as anode: elucidation and characterization of new by-products using LC-TOF/MS
description Metoprolol (MTP) is one of pharmaceuticals used for treatment of heart failure and hypertension. It was frequently detected in wastewater samples either influent or effluent. The application of graphite-PVC composite as anode was investigated for the degradation of metoprolol in the presence of strong electrolyte such as sodium chloride (NaCl). The degradation rate was strongly influenced by initial concentrations of metoprolol, NaCl concentration and applied voltage. An initial concentration of 2 mg/L was eliminated more than 95% after 30 min under optimum conditions; 5000 mg/L NaCl and 5 V. The consumption energy of the electrochemical reaction was 0.665 Wh/mg for metoprolol after 30 min. The kinetic rate constant of metoprolol could be ranged between 0.0016 and 0.0801 min-1. The electrochemical degradation efficiency of metoprolol and its by-products has been achieved. The degradation of metoprolol produced four transformated products as investigated and elucidated using liquid chromatography-time of flight/mass spectrometry. The proposed degradation pathway of metoprolol was schemed on the base of the identified intermediates.
format Article
author Mussa, Z. H.
Al-Qaim, F. F.
Yuzir, A.
Shameli, K.
author_facet Mussa, Z. H.
Al-Qaim, F. F.
Yuzir, A.
Shameli, K.
author_sort Mussa, Z. H.
title Electrochemical degradation of metoprolol using graphite-pvc composite as anode: elucidation and characterization of new by-products using LC-TOF/MS
title_short Electrochemical degradation of metoprolol using graphite-pvc composite as anode: elucidation and characterization of new by-products using LC-TOF/MS
title_full Electrochemical degradation of metoprolol using graphite-pvc composite as anode: elucidation and characterization of new by-products using LC-TOF/MS
title_fullStr Electrochemical degradation of metoprolol using graphite-pvc composite as anode: elucidation and characterization of new by-products using LC-TOF/MS
title_full_unstemmed Electrochemical degradation of metoprolol using graphite-pvc composite as anode: elucidation and characterization of new by-products using LC-TOF/MS
title_sort electrochemical degradation of metoprolol using graphite-pvc composite as anode: elucidation and characterization of new by-products using lc-tof/ms
publisher Sociedad Quimica de Mexico A.C.
publishDate 2020
url http://eprints.utm.my/id/eprint/93652/
http://dx.doi.org/10.29356/jmcs.v64i3.1139
_version_ 1720980105486925824
score 13.211869

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