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Safety and health risk assessment methodology of dermal and inhalation exposure to formulated products ingredients

Consumers are commonly exposed to numerous chemical ingredients found in various formulated products especially household and personal care products. Therefore, identification of hazardous ingredients contained in those products should be performed at the early stages of product design to reduce the...

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Main Authors: Raslan, Rafeqah, Hassim, Mimi H., Chemmangattuvalappil, Nishanth G., Ng, Denny K. S., Ten, Joon Yoon
Format: Article
Published: Elsevier Inc. 2020
Subjects:
TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/93183/
http://dx.doi.org/10.1016/j.yrtph.2020.104753
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spelling my.utm.931832021-11-19T03:24:07Z http://eprints.utm.my/id/eprint/93183/ Safety and health risk assessment methodology of dermal and inhalation exposure to formulated products ingredients Raslan, Rafeqah Hassim, Mimi H. Chemmangattuvalappil, Nishanth G. Ng, Denny K. S. Ten, Joon Yoon TP Chemical technology Consumers are commonly exposed to numerous chemical ingredients found in various formulated products especially household and personal care products. Therefore, identification of hazardous ingredients contained in those products should be performed at the early stages of product design to reduce the high cost of redesigning the products at the final stage. Thus, a systematic safety and health risk assessment methodology is required for the product formulation design. In this work, a two-step index-based methodology is presented to estimate the severity of the hazards and the magnitude of risks. In Tier 1 assessment, potential hazards of the ingredients were identified by following the Product Ingredient Safety Index (PISI). The basic toxicology information of ingredients was required for this assessment. In Tier 2 assessment, the extent of risks of the ingredients via dermal and inhalation exposure routes were evaluated. At this stage, the concentration of ingredients and the amount of exposure were considered. The value of Margin of Exposure (MOE) was used as an indicator in the development of Product Ingredient Exposure Index (PIEI). To demonstrate the proposed methodology, a case study on the evaluation of potential hazards and the risks from ingredients used in personal care product formulations were performed. Elsevier Inc. 2020-10 Article PeerReviewed Raslan, Rafeqah and Hassim, Mimi H. and Chemmangattuvalappil, Nishanth G. and Ng, Denny K. S. and Ten, Joon Yoon (2020) Safety and health risk assessment methodology of dermal and inhalation exposure to formulated products ingredients. Regulatory Toxicology and Pharmacology, 116 . ISSN 0273-2300 http://dx.doi.org/10.1016/j.yrtph.2020.104753 DOI:10.1016/j.yrtph.2020.104753
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic TP Chemical technology
spellingShingle TP Chemical technology
Raslan, Rafeqah
Hassim, Mimi H.
Chemmangattuvalappil, Nishanth G.
Ng, Denny K. S.
Ten, Joon Yoon
Safety and health risk assessment methodology of dermal and inhalation exposure to formulated products ingredients
description Consumers are commonly exposed to numerous chemical ingredients found in various formulated products especially household and personal care products. Therefore, identification of hazardous ingredients contained in those products should be performed at the early stages of product design to reduce the high cost of redesigning the products at the final stage. Thus, a systematic safety and health risk assessment methodology is required for the product formulation design. In this work, a two-step index-based methodology is presented to estimate the severity of the hazards and the magnitude of risks. In Tier 1 assessment, potential hazards of the ingredients were identified by following the Product Ingredient Safety Index (PISI). The basic toxicology information of ingredients was required for this assessment. In Tier 2 assessment, the extent of risks of the ingredients via dermal and inhalation exposure routes were evaluated. At this stage, the concentration of ingredients and the amount of exposure were considered. The value of Margin of Exposure (MOE) was used as an indicator in the development of Product Ingredient Exposure Index (PIEI). To demonstrate the proposed methodology, a case study on the evaluation of potential hazards and the risks from ingredients used in personal care product formulations were performed.
format Article
author Raslan, Rafeqah
Hassim, Mimi H.
Chemmangattuvalappil, Nishanth G.
Ng, Denny K. S.
Ten, Joon Yoon
author_facet Raslan, Rafeqah
Hassim, Mimi H.
Chemmangattuvalappil, Nishanth G.
Ng, Denny K. S.
Ten, Joon Yoon
author_sort Raslan, Rafeqah
title Safety and health risk assessment methodology of dermal and inhalation exposure to formulated products ingredients
title_short Safety and health risk assessment methodology of dermal and inhalation exposure to formulated products ingredients
title_full Safety and health risk assessment methodology of dermal and inhalation exposure to formulated products ingredients
title_fullStr Safety and health risk assessment methodology of dermal and inhalation exposure to formulated products ingredients
title_full_unstemmed Safety and health risk assessment methodology of dermal and inhalation exposure to formulated products ingredients
title_sort safety and health risk assessment methodology of dermal and inhalation exposure to formulated products ingredients
publisher Elsevier Inc.
publishDate 2020
url http://eprints.utm.my/id/eprint/93183/
http://dx.doi.org/10.1016/j.yrtph.2020.104753
_version_ 1717093432124506112
score 13.211869

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