Staff View: Synthesis of silver-coated bioactive nanocomposite scaffolds based on grafted beta- glucan/hydroxyapatite via freeze-drying method: anti-microbial and biocompatibility evaluation for bone tissue engineering

Synthesis of silver-coated bioactive nanocomposite scaffolds based on grafted beta- glucan/hydroxyapatite via freeze-drying method: anti-microbial and biocompatibility evaluation for bone tissue engineering

Advancement and development in bone tissue engineering, particularly that of composite scaffolds, are of great importance for bone tissue engineering. We have synthesized polymeric matrix using biopolymer (β-glucan), acrylic acid, and nano-hydroxyapatite through free radical polymerization method. B...

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Main Authors:	Khan, Muhammad Umar Aslam, Al-Thebaiti, Mesfer A., Hashmi, Muhammad Uzair, Aftab, Saira, Abd. Razak, Saiful Izwan, Abu Hassan, Shukur, Abdul Kadir, Mohammed Rafiq, Amin, Rashid
Format:	Article
Language:	English
Published:	MDPI 2020
Subjects:	TP Chemical technology
Online Access:	http://eprints.utm.my/id/eprint/92271/1/MuhammadUmar2020_SynthesisofSilverCoatedBioactiveNanocomposite.pdf http://eprints.utm.my/id/eprint/92271/ http://dx.doi.org/10.3390/ma13040971
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spelling	my.utm.922712021-09-28T07:43:28Z http://eprints.utm.my/id/eprint/92271/ Synthesis of silver-coated bioactive nanocomposite scaffolds based on grafted beta- glucan/hydroxyapatite via freeze-drying method: anti-microbial and biocompatibility evaluation for bone tissue engineering Khan, Muhammad Umar Aslam Al-Thebaiti, Mesfer A. Hashmi, Muhammad Uzair Aftab, Saira Abd. Razak, Saiful Izwan Abu Hassan, Shukur Abdul Kadir, Mohammed Rafiq Amin, Rashid TP Chemical technology Advancement and development in bone tissue engineering, particularly that of composite scaffolds, are of great importance for bone tissue engineering. We have synthesized polymeric matrix using biopolymer (β-glucan), acrylic acid, and nano-hydroxyapatite through free radical polymerization method. Bioactive nanocomposite scaffolds (BNSs) were fabricated using the freeze-drying method and Ag was coated by the dip-coating method. The scaffolds have been characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-ray diffraction analysis (XRD) to investigate their functional groups, surface morphology, and phase analysis, respectively. The pore size and porosity of all BNS samples were found to be dependent on silver concentration. Mechanical testing of all BNS samples have substantial compressive strength in dry form that is closer to cancellous bone. The samples of BNS showed substantial antibacterial effect against DH5 alpha E. coli. The biological studies conducted using the MC3T3-E1 cell line via neutral red dye assay on the scaffolds have found to be biocompatible and non-cytotoxic. These bioactive scaffolds can bring numerous applications for bone tissue repairs and regenerations. MDPI 2020-02-01 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/92271/1/MuhammadUmar2020_SynthesisofSilverCoatedBioactiveNanocomposite.pdf Khan, Muhammad Umar Aslam and Al-Thebaiti, Mesfer A. and Hashmi, Muhammad Uzair and Aftab, Saira and Abd. Razak, Saiful Izwan and Abu Hassan, Shukur and Abdul Kadir, Mohammed Rafiq and Amin, Rashid (2020) Synthesis of silver-coated bioactive nanocomposite scaffolds based on grafted beta- glucan/hydroxyapatite via freeze-drying method: anti-microbial and biocompatibility evaluation for bone tissue engineering. Materials, 13 (4). pp. 1-18. ISSN 1996-1944 http://dx.doi.org/10.3390/ma13040971 DOI:10.3390/ma13040971
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Khan, Muhammad Umar Aslam Al-Thebaiti, Mesfer A. Hashmi, Muhammad Uzair Aftab, Saira Abd. Razak, Saiful Izwan Abu Hassan, Shukur Abdul Kadir, Mohammed Rafiq Amin, Rashid Synthesis of silver-coated bioactive nanocomposite scaffolds based on grafted beta- glucan/hydroxyapatite via freeze-drying method: anti-microbial and biocompatibility evaluation for bone tissue engineering
description	Advancement and development in bone tissue engineering, particularly that of composite scaffolds, are of great importance for bone tissue engineering. We have synthesized polymeric matrix using biopolymer (β-glucan), acrylic acid, and nano-hydroxyapatite through free radical polymerization method. Bioactive nanocomposite scaffolds (BNSs) were fabricated using the freeze-drying method and Ag was coated by the dip-coating method. The scaffolds have been characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-ray diffraction analysis (XRD) to investigate their functional groups, surface morphology, and phase analysis, respectively. The pore size and porosity of all BNS samples were found to be dependent on silver concentration. Mechanical testing of all BNS samples have substantial compressive strength in dry form that is closer to cancellous bone. The samples of BNS showed substantial antibacterial effect against DH5 alpha E. coli. The biological studies conducted using the MC3T3-E1 cell line via neutral red dye assay on the scaffolds have found to be biocompatible and non-cytotoxic. These bioactive scaffolds can bring numerous applications for bone tissue repairs and regenerations.
format	Article
author	Khan, Muhammad Umar Aslam Al-Thebaiti, Mesfer A. Hashmi, Muhammad Uzair Aftab, Saira Abd. Razak, Saiful Izwan Abu Hassan, Shukur Abdul Kadir, Mohammed Rafiq Amin, Rashid
author_facet	Khan, Muhammad Umar Aslam Al-Thebaiti, Mesfer A. Hashmi, Muhammad Uzair Aftab, Saira Abd. Razak, Saiful Izwan Abu Hassan, Shukur Abdul Kadir, Mohammed Rafiq Amin, Rashid
author_sort	Khan, Muhammad Umar Aslam
title	Synthesis of silver-coated bioactive nanocomposite scaffolds based on grafted beta- glucan/hydroxyapatite via freeze-drying method: anti-microbial and biocompatibility evaluation for bone tissue engineering
title_short	Synthesis of silver-coated bioactive nanocomposite scaffolds based on grafted beta- glucan/hydroxyapatite via freeze-drying method: anti-microbial and biocompatibility evaluation for bone tissue engineering
title_full	Synthesis of silver-coated bioactive nanocomposite scaffolds based on grafted beta- glucan/hydroxyapatite via freeze-drying method: anti-microbial and biocompatibility evaluation for bone tissue engineering
title_fullStr	Synthesis of silver-coated bioactive nanocomposite scaffolds based on grafted beta- glucan/hydroxyapatite via freeze-drying method: anti-microbial and biocompatibility evaluation for bone tissue engineering
title_full_unstemmed	Synthesis of silver-coated bioactive nanocomposite scaffolds based on grafted beta- glucan/hydroxyapatite via freeze-drying method: anti-microbial and biocompatibility evaluation for bone tissue engineering
title_sort	synthesis of silver-coated bioactive nanocomposite scaffolds based on grafted beta- glucan/hydroxyapatite via freeze-drying method: anti-microbial and biocompatibility evaluation for bone tissue engineering
publisher	MDPI
publishDate	2020
url	http://eprints.utm.my/id/eprint/92271/1/MuhammadUmar2020_SynthesisofSilverCoatedBioactiveNanocomposite.pdf http://eprints.utm.my/id/eprint/92271/ http://dx.doi.org/10.3390/ma13040971
_version_	1712285073115447296
score	13.211869

Synthesis of silver-coated bioactive nanocomposite scaffolds based on grafted beta- glucan/hydroxyapatite via freeze-drying method: anti-microbial and biocompatibility evaluation for bone tissue engineering

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