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Micropillar based active microfluidic mixer for the detection of glucose concentration

Active microfluidic mixer has attracted remarkable interest towards the applications in the Lab on Chip (LoC) for fast and accurate fluid mixing. In this work, the standard MEMS processes have been successfully implemented to fabricate the active electromagnetic microfluidic mixer incorporating micr...

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Main Authors: Pawinanto, Roer Eka, Yunas, Jumril, Hashim, Abdul Manaf
Format: Article
Published: Elsevier B.V. 2020
Subjects:
TA Engineering (General). Civil engineering (General)
Online Access:http://eprints.utm.my/id/eprint/91128/
http://dx.doi.org/10.1016/j.mee.2020.111452
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spelling my.utm.911282021-05-31T13:47:28Z http://eprints.utm.my/id/eprint/91128/ Micropillar based active microfluidic mixer for the detection of glucose concentration Pawinanto, Roer Eka Yunas, Jumril Hashim, Abdul Manaf TA Engineering (General). Civil engineering (General) Active microfluidic mixer has attracted remarkable interest towards the applications in the Lab on Chip (LoC) for fast and accurate fluid mixing. In this work, the standard MEMS processes have been successfully implemented to fabricate the active electromagnetic microfluidic mixer incorporating micropillar on flexible membrane for glucose measurement. Three main parts of the mixer, i.e., a planar electromagnetic coil with permanent magnet, a mechanical movable membrane with pillar and microfluidic channels that were fabricated separately and later bonded with corona discharging process to complete the construction of the microfluidic mixer. The mechanical movable membrane and microfluidic channels are made of polymer and fabricated using soft-lithography technique. Analysis results show that the fabricated microfluidic mixer operated using low electrical current of below 0.5 A produced the mixing index above 0.8 within 4 s. Mixture analysis of fluid samples tested at frequencies of 1.1 kHz, 2.3 kHz and 3.7 kHz shows much better mixing performance as compared to its passive mode condition. The functionality of the fabricated mixer was tested by mixing the DNS reagent and glucose solution. The detection of glucose concentration in the microfluidic mixer chip is indicated by comparing the correlation coefficient R2 with the conventional method. The evaluation result shows that the R2 of the mixture produced by the fabricated device shows a comparable value with that of conventional method showing a very promising approach for the diabetic patient diagnosis and food analysis. Elsevier B.V. 2020-10-15 Article PeerReviewed Pawinanto, Roer Eka and Yunas, Jumril and Hashim, Abdul Manaf (2020) Micropillar based active microfluidic mixer for the detection of glucose concentration. Microelectronic Engineering, 234 . pp. 1-10. ISSN 0167-9317 http://dx.doi.org/10.1016/j.mee.2020.111452 DOI:10.1016/j.mee.2020.111452
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic TA Engineering (General). Civil engineering (General)
spellingShingle TA Engineering (General). Civil engineering (General)
Pawinanto, Roer Eka
Yunas, Jumril
Hashim, Abdul Manaf
Micropillar based active microfluidic mixer for the detection of glucose concentration
description Active microfluidic mixer has attracted remarkable interest towards the applications in the Lab on Chip (LoC) for fast and accurate fluid mixing. In this work, the standard MEMS processes have been successfully implemented to fabricate the active electromagnetic microfluidic mixer incorporating micropillar on flexible membrane for glucose measurement. Three main parts of the mixer, i.e., a planar electromagnetic coil with permanent magnet, a mechanical movable membrane with pillar and microfluidic channels that were fabricated separately and later bonded with corona discharging process to complete the construction of the microfluidic mixer. The mechanical movable membrane and microfluidic channels are made of polymer and fabricated using soft-lithography technique. Analysis results show that the fabricated microfluidic mixer operated using low electrical current of below 0.5 A produced the mixing index above 0.8 within 4 s. Mixture analysis of fluid samples tested at frequencies of 1.1 kHz, 2.3 kHz and 3.7 kHz shows much better mixing performance as compared to its passive mode condition. The functionality of the fabricated mixer was tested by mixing the DNS reagent and glucose solution. The detection of glucose concentration in the microfluidic mixer chip is indicated by comparing the correlation coefficient R2 with the conventional method. The evaluation result shows that the R2 of the mixture produced by the fabricated device shows a comparable value with that of conventional method showing a very promising approach for the diabetic patient diagnosis and food analysis.
format Article
author Pawinanto, Roer Eka
Yunas, Jumril
Hashim, Abdul Manaf
author_facet Pawinanto, Roer Eka
Yunas, Jumril
Hashim, Abdul Manaf
author_sort Pawinanto, Roer Eka
title Micropillar based active microfluidic mixer for the detection of glucose concentration
title_short Micropillar based active microfluidic mixer for the detection of glucose concentration
title_full Micropillar based active microfluidic mixer for the detection of glucose concentration
title_fullStr Micropillar based active microfluidic mixer for the detection of glucose concentration
title_full_unstemmed Micropillar based active microfluidic mixer for the detection of glucose concentration
title_sort micropillar based active microfluidic mixer for the detection of glucose concentration
publisher Elsevier B.V.
publishDate 2020
url http://eprints.utm.my/id/eprint/91128/
http://dx.doi.org/10.1016/j.mee.2020.111452
_version_ 1702169649067589632
score 13.211869

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