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Effect of solvent on the physicochemical properties of electrospun nanocomposite with gamat oil and cerium oxide for potential medical engineering application

Wound healing is a complex and intricate process that has affected millions of people due to improper management. Scaffolds are capable of exhibiting an environment that is optimum for the regeneration of damaged tissues and hence, enhances the process of wound healing. The current study was done to...

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Main Authors: Narruddin, Wan Nurul Hannah, Jaganathan, Saravana Kumar, Mohd. Khudzari, Ahmad Zahran, Ismail, Ahmad Fauzi
Format: Article
Published: Taylor and Francis Ltd. 2020
Subjects:
Q Science (General)
Online Access:http://eprints.utm.my/id/eprint/90139/
http://dx.doi.org/10.1080/00405000.2020.1828553
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spelling my.utm.901392021-03-31T06:21:41Z http://eprints.utm.my/id/eprint/90139/ Effect of solvent on the physicochemical properties of electrospun nanocomposite with gamat oil and cerium oxide for potential medical engineering application Narruddin, Wan Nurul Hannah Jaganathan, Saravana Kumar Mohd. Khudzari, Ahmad Zahran Ismail, Ahmad Fauzi Q Science (General) Wound healing is a complex and intricate process that has affected millions of people due to improper management. Scaffolds are capable of exhibiting an environment that is optimum for the regeneration of damaged tissues and hence, enhances the process of wound healing. The current study was done to fabricate nanocomposites composed of polycaprolactone (PCL) as well as gamat oil and cerium (Ce) oxide particles of different ratios through electrospinning that can be used in the healing of wounds. The polymeric solutions were dissolved in two different solvent systems to investigate the influence of solvent parameters on the physical properties of nanofibres. Solvent system A was a mixture of chloroform and dimethylformamide (DMF), while solvent system B was a mixture of acetone and DMF. Morphological analysis of fibre diameter indicated a decrease and the reduction of diameter was more pronounced in solvent system B rather than A. Contact angle measurements revealed that the addition of added constituents to pure PCL have increased its’ hydrophobicity nature for nanocomposites using both solvent systems. Fourier transform infrared spectroscopy (FTIR) results indicated chemical interactions between PCL, gamat oil and cerium oxide as detected through the shift in absorption bands. Lastly, mechanical testing of the nanocomposites indicated that using both solvent systems, there was an increase in the tensile strengths when gamat oil and Ce oxide were added. The newly fabricated nanocomposites using different solvent systems demonstrated physicochemical properties that are well suited for wound healing applications. Taylor and Francis Ltd. 2020 Article PeerReviewed Narruddin, Wan Nurul Hannah and Jaganathan, Saravana Kumar and Mohd. Khudzari, Ahmad Zahran and Ismail, Ahmad Fauzi (2020) Effect of solvent on the physicochemical properties of electrospun nanocomposite with gamat oil and cerium oxide for potential medical engineering application. Journal of the Textile Institute . p. 10. ISSN 0040-5000 http://dx.doi.org/10.1080/00405000.2020.1828553
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic Q Science (General)
spellingShingle Q Science (General)
Narruddin, Wan Nurul Hannah
Jaganathan, Saravana Kumar
Mohd. Khudzari, Ahmad Zahran
Ismail, Ahmad Fauzi
Effect of solvent on the physicochemical properties of electrospun nanocomposite with gamat oil and cerium oxide for potential medical engineering application
description Wound healing is a complex and intricate process that has affected millions of people due to improper management. Scaffolds are capable of exhibiting an environment that is optimum for the regeneration of damaged tissues and hence, enhances the process of wound healing. The current study was done to fabricate nanocomposites composed of polycaprolactone (PCL) as well as gamat oil and cerium (Ce) oxide particles of different ratios through electrospinning that can be used in the healing of wounds. The polymeric solutions were dissolved in two different solvent systems to investigate the influence of solvent parameters on the physical properties of nanofibres. Solvent system A was a mixture of chloroform and dimethylformamide (DMF), while solvent system B was a mixture of acetone and DMF. Morphological analysis of fibre diameter indicated a decrease and the reduction of diameter was more pronounced in solvent system B rather than A. Contact angle measurements revealed that the addition of added constituents to pure PCL have increased its’ hydrophobicity nature for nanocomposites using both solvent systems. Fourier transform infrared spectroscopy (FTIR) results indicated chemical interactions between PCL, gamat oil and cerium oxide as detected through the shift in absorption bands. Lastly, mechanical testing of the nanocomposites indicated that using both solvent systems, there was an increase in the tensile strengths when gamat oil and Ce oxide were added. The newly fabricated nanocomposites using different solvent systems demonstrated physicochemical properties that are well suited for wound healing applications.
format Article
author Narruddin, Wan Nurul Hannah
Jaganathan, Saravana Kumar
Mohd. Khudzari, Ahmad Zahran
Ismail, Ahmad Fauzi
author_facet Narruddin, Wan Nurul Hannah
Jaganathan, Saravana Kumar
Mohd. Khudzari, Ahmad Zahran
Ismail, Ahmad Fauzi
author_sort Narruddin, Wan Nurul Hannah
title Effect of solvent on the physicochemical properties of electrospun nanocomposite with gamat oil and cerium oxide for potential medical engineering application
title_short Effect of solvent on the physicochemical properties of electrospun nanocomposite with gamat oil and cerium oxide for potential medical engineering application
title_full Effect of solvent on the physicochemical properties of electrospun nanocomposite with gamat oil and cerium oxide for potential medical engineering application
title_fullStr Effect of solvent on the physicochemical properties of electrospun nanocomposite with gamat oil and cerium oxide for potential medical engineering application
title_full_unstemmed Effect of solvent on the physicochemical properties of electrospun nanocomposite with gamat oil and cerium oxide for potential medical engineering application
title_sort effect of solvent on the physicochemical properties of electrospun nanocomposite with gamat oil and cerium oxide for potential medical engineering application
publisher Taylor and Francis Ltd.
publishDate 2020
url http://eprints.utm.my/id/eprint/90139/
http://dx.doi.org/10.1080/00405000.2020.1828553
_version_ 1696976267082989568
score 13.211869

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