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Bioactive algal-derived polysaccharides: multi-functionalization, therapeutic potential and biomedical applications

Background: In recent decades, there has been an increased interest in the utilization of polysaccharides showing biological activity for various novel applications owing to their biocompatibility, biodegradability, non-toxicity, and some specific therapeutic activities. Increasing studies have star...

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Main Authors: Muhamad, Ida Idayu, Zulkifli, Nabilah, Selvakumaran, Suguna, Md. Lazim, Nurul Asmak
Format: Article
Published: Bentham Science Publishers 2019
Subjects:
TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/89558/
http://dx.doi.org/10.2174/1381612825666190618152133
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spelling my.utm.895582021-02-22T01:47:58Z http://eprints.utm.my/id/eprint/89558/ Bioactive algal-derived polysaccharides: multi-functionalization, therapeutic potential and biomedical applications Muhamad, Ida Idayu Zulkifli, Nabilah Selvakumaran, Suguna Md. Lazim, Nurul Asmak TP Chemical technology Background: In recent decades, there has been an increased interest in the utilization of polysaccharides showing biological activity for various novel applications owing to their biocompatibility, biodegradability, non-toxicity, and some specific therapeutic activities. Increasing studies have started in the past few years to develop algal polysaccharides-based biomaterials for various applications. Methods: Saccharide mapping or enzymatic profiling plays a role in quality control of polysaccharides. Whereby, in vitro and in vivo tests as well as toxicity level discriminating polysaccharides biological activities. Extraction and purification methods are performed in obtaining algal derived polysaccharides followed by chromatographic profiles of their active compounds, structural features, physicochemical properties, and reported biological activities. Results: Marine algae are capable of synthesizing Glycosaminoglycans (GAGs) and non-GAGs or GAG mimetics such as sulfated glycans. The cell walls of algae are rich in sulfated polysaccharides, including alginate, carrageenan, ulvan and fucoidan. These biopolymers are widely used algal-derived polysaccharides for biological and biomedical applications due to their biocompatibility and availability. They constitute biochemical compounds that have multi-functionalization, therapeutic potential and immunomodulatory abilities, making them promising bioactive products and biomaterials with a wide range of biomedical applications. Conclusion: Algal-derived polysaccharides with clearly elucidated compositions/structures, identified cellular activities, as well as desirable physical properties have shown the potential that may create new opportunities. They could be maximally exploited to serve as therapeutic tools such as immunoregulatory agents or drug delivery vehicles. Hence, novel strategies could be applied to tailor multi-functionalization of the polysaccharides from algal species with vast biomedical application potentials. Bentham Science Publishers 2019 Article PeerReviewed Muhamad, Ida Idayu and Zulkifli, Nabilah and Selvakumaran, Suguna and Md. Lazim, Nurul Asmak (2019) Bioactive algal-derived polysaccharides: multi-functionalization, therapeutic potential and biomedical applications. Current Pharmaceutical Design, 25 (11). pp. 1147-1162. ISSN 1381-6128 http://dx.doi.org/10.2174/1381612825666190618152133
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic TP Chemical technology
spellingShingle TP Chemical technology
Muhamad, Ida Idayu
Zulkifli, Nabilah
Selvakumaran, Suguna
Md. Lazim, Nurul Asmak
Bioactive algal-derived polysaccharides: multi-functionalization, therapeutic potential and biomedical applications
description Background: In recent decades, there has been an increased interest in the utilization of polysaccharides showing biological activity for various novel applications owing to their biocompatibility, biodegradability, non-toxicity, and some specific therapeutic activities. Increasing studies have started in the past few years to develop algal polysaccharides-based biomaterials for various applications. Methods: Saccharide mapping or enzymatic profiling plays a role in quality control of polysaccharides. Whereby, in vitro and in vivo tests as well as toxicity level discriminating polysaccharides biological activities. Extraction and purification methods are performed in obtaining algal derived polysaccharides followed by chromatographic profiles of their active compounds, structural features, physicochemical properties, and reported biological activities. Results: Marine algae are capable of synthesizing Glycosaminoglycans (GAGs) and non-GAGs or GAG mimetics such as sulfated glycans. The cell walls of algae are rich in sulfated polysaccharides, including alginate, carrageenan, ulvan and fucoidan. These biopolymers are widely used algal-derived polysaccharides for biological and biomedical applications due to their biocompatibility and availability. They constitute biochemical compounds that have multi-functionalization, therapeutic potential and immunomodulatory abilities, making them promising bioactive products and biomaterials with a wide range of biomedical applications. Conclusion: Algal-derived polysaccharides with clearly elucidated compositions/structures, identified cellular activities, as well as desirable physical properties have shown the potential that may create new opportunities. They could be maximally exploited to serve as therapeutic tools such as immunoregulatory agents or drug delivery vehicles. Hence, novel strategies could be applied to tailor multi-functionalization of the polysaccharides from algal species with vast biomedical application potentials.
format Article
author Muhamad, Ida Idayu
Zulkifli, Nabilah
Selvakumaran, Suguna
Md. Lazim, Nurul Asmak
author_facet Muhamad, Ida Idayu
Zulkifli, Nabilah
Selvakumaran, Suguna
Md. Lazim, Nurul Asmak
author_sort Muhamad, Ida Idayu
title Bioactive algal-derived polysaccharides: multi-functionalization, therapeutic potential and biomedical applications
title_short Bioactive algal-derived polysaccharides: multi-functionalization, therapeutic potential and biomedical applications
title_full Bioactive algal-derived polysaccharides: multi-functionalization, therapeutic potential and biomedical applications
title_fullStr Bioactive algal-derived polysaccharides: multi-functionalization, therapeutic potential and biomedical applications
title_full_unstemmed Bioactive algal-derived polysaccharides: multi-functionalization, therapeutic potential and biomedical applications
title_sort bioactive algal-derived polysaccharides: multi-functionalization, therapeutic potential and biomedical applications
publisher Bentham Science Publishers
publishDate 2019
url http://eprints.utm.my/id/eprint/89558/
http://dx.doi.org/10.2174/1381612825666190618152133
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score 13.211869

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