Staff View: X-Ray powder diffraction data for a new pirazoline compound

X-Ray powder diffraction data for a new pirazoline compound

Pyrazolines are important agents in medicinal chemistry as a promising scaffold for structural modification and drug development studies due to their wide range of biological activities such as anticancer, antifungal, antibacterial, antidepressant, anticonvulsant, antitubercular, antioxidant, antile...

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Main Authors:	Gerzon, Delgado, Pilar, Delgado Niño, Lobaton, Robert, Liew, Suk Ming, Jamalis, Joazaizulfazli
Format:	Article
Published:	Tche Quimica Group 2019
Subjects:	QD Chemistry
Online Access:	http://eprints.utm.my/id/eprint/89484/ https://journals.indexcopernicus.com/api/file/viewByFileId/906785.pdf
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id	my.utm.89484
record_format	eprints
spelling	my.utm.894842021-02-22T01:47:42Z http://eprints.utm.my/id/eprint/89484/ X-Ray powder diffraction data for a new pirazoline compound Gerzon, Delgado Pilar, Delgado Niño Lobaton, Robert Liew, Suk Ming Jamalis, Joazaizulfazli QD Chemistry Pyrazolines are important agents in medicinal chemistry as a promising scaffold for structural modification and drug development studies due to their wide range of biological activities such as anticancer, antifungal, antibacterial, antidepressant, anticonvulsant, antitubercular, antioxidant, antileishmanial and antiinflammatory activity. These heterocyclic compounds can be prepared by refluxing chalcone with hydrazine hydrate and anhydrous sodium acetate in the presence of glacial acetic acid. The structural characterization, molecular and crystalline structure, of these organic compounds, allows studying their biological properties to know their potential applications. Hence the use of XRPD is very important because it allows obtaining a record to be used as a method of identification. The aim of this investigation was to obtain and reported good quality X-ray powder diffraction data the pyrazoline compound 1-(3-(4-iodophenyl)-5-(3-methyl thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethan-1-one, which could be used as potential anti-microbial and anti-cancer agent. The powder pattern was indexed in the monoclinic space group I2/a with unit cell parameters a = 25.440(5) Å, b = 5.124(2) Å, c = 26.261(6) Å, β = 105.75(2)° and figures of merit M20= 38.2 and F20= 66.6 (0.00573, 53). All measured lines were indexed and are consistent with the monoclinic space group. The powder pattern will be included in the Powder Diffraction File database to be used as a reference. Tche Quimica Group 2019 Article PeerReviewed Gerzon, Delgado and Pilar, Delgado Niño and Lobaton, Robert and Liew, Suk Ming and Jamalis, Joazaizulfazli (2019) X-Ray powder diffraction data for a new pirazoline compound. Periodico Tche Quimica, 16 (33). pp. 524-529. ISSN 1806-0374 https://journals.indexcopernicus.com/api/file/viewByFileId/906785.pdf
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
topic	QD Chemistry
spellingShingle	QD Chemistry Gerzon, Delgado Pilar, Delgado Niño Lobaton, Robert Liew, Suk Ming Jamalis, Joazaizulfazli X-Ray powder diffraction data for a new pirazoline compound
description	Pyrazolines are important agents in medicinal chemistry as a promising scaffold for structural modification and drug development studies due to their wide range of biological activities such as anticancer, antifungal, antibacterial, antidepressant, anticonvulsant, antitubercular, antioxidant, antileishmanial and antiinflammatory activity. These heterocyclic compounds can be prepared by refluxing chalcone with hydrazine hydrate and anhydrous sodium acetate in the presence of glacial acetic acid. The structural characterization, molecular and crystalline structure, of these organic compounds, allows studying their biological properties to know their potential applications. Hence the use of XRPD is very important because it allows obtaining a record to be used as a method of identification. The aim of this investigation was to obtain and reported good quality X-ray powder diffraction data the pyrazoline compound 1-(3-(4-iodophenyl)-5-(3-methyl thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethan-1-one, which could be used as potential anti-microbial and anti-cancer agent. The powder pattern was indexed in the monoclinic space group I2/a with unit cell parameters a = 25.440(5) Å, b = 5.124(2) Å, c = 26.261(6) Å, β = 105.75(2)° and figures of merit M20= 38.2 and F20= 66.6 (0.00573, 53). All measured lines were indexed and are consistent with the monoclinic space group. The powder pattern will be included in the Powder Diffraction File database to be used as a reference.
format	Article
author	Gerzon, Delgado Pilar, Delgado Niño Lobaton, Robert Liew, Suk Ming Jamalis, Joazaizulfazli
author_facet	Gerzon, Delgado Pilar, Delgado Niño Lobaton, Robert Liew, Suk Ming Jamalis, Joazaizulfazli
author_sort	Gerzon, Delgado
title	X-Ray powder diffraction data for a new pirazoline compound
title_short	X-Ray powder diffraction data for a new pirazoline compound
title_full	X-Ray powder diffraction data for a new pirazoline compound
title_fullStr	X-Ray powder diffraction data for a new pirazoline compound
title_full_unstemmed	X-Ray powder diffraction data for a new pirazoline compound
title_sort	x-ray powder diffraction data for a new pirazoline compound
publisher	Tche Quimica Group
publishDate	2019
url	http://eprints.utm.my/id/eprint/89484/ https://journals.indexcopernicus.com/api/file/viewByFileId/906785.pdf
_version_	1692991788852183040
score	13.211869

X-Ray powder diffraction data for a new pirazoline compound

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