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Numerical computation of signal stimulation from Ligand-EGFR binding during invadopodia formation

Invadopodia are finger-like protrusions located at subcellular membrane which can lead to cancer cell invasion. The formation of invadopodia involves several steps such as actin polymerizations, degradation of extracellular matrix which produce ligand and signal stimulation that is occurred from the...

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Main Authors: Yaacob, Noorehan, Noor Azhuan, Nur Azura, Shafie, Sharidan, Admon, Mohd. Ariff
Format: Article
Published: Penerbit UTM Press 2019
Subjects:
QA Mathematics
Online Access:http://eprints.utm.my/id/eprint/89446/
http://dx.doi.org/10.11113/matematika.v35.n4.1268
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spelling my.utm.894462021-02-22T01:47:36Z http://eprints.utm.my/id/eprint/89446/ Numerical computation of signal stimulation from Ligand-EGFR binding during invadopodia formation Yaacob, Noorehan Noor Azhuan, Nur Azura Shafie, Sharidan Admon, Mohd. Ariff QA Mathematics Invadopodia are finger-like protrusions located at subcellular membrane which can lead to cancer cell invasion. The formation of invadopodia involves several steps such as actin polymerizations, degradation of extracellular matrix which produce ligand and signal stimulation that is occurred from the binding of ligand with epidermal growth factor receptor. In this paper, a mathematical model of signal transduction is investigated. Both signal and ligand are represented by Laplace equation with Dirichlet boundary condition for each region. The cell membrane is treated as free boundary surface to separate any activity that occurred in intracellular and extracellular regions. The motion of the interface is taken as gradient of nterior signal and the cell membrane is set as zero level set function. The problem is solved numerically using finite difference scheme of upwind, interpolation and extrapolation methods. The results showed that the formation of invadopodia is formed when protrusions exist on the cell membrane. Penerbit UTM Press 2019-12 Article PeerReviewed Yaacob, Noorehan and Noor Azhuan, Nur Azura and Shafie, Sharidan and Admon, Mohd. Ariff (2019) Numerical computation of signal stimulation from Ligand-EGFR binding during invadopodia formation. Matematika, 35 (SI). pp. 139-148. ISSN 0127-8274 http://dx.doi.org/10.11113/matematika.v35.n4.1268
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic QA Mathematics
spellingShingle QA Mathematics
Yaacob, Noorehan
Noor Azhuan, Nur Azura
Shafie, Sharidan
Admon, Mohd. Ariff
Numerical computation of signal stimulation from Ligand-EGFR binding during invadopodia formation
description Invadopodia are finger-like protrusions located at subcellular membrane which can lead to cancer cell invasion. The formation of invadopodia involves several steps such as actin polymerizations, degradation of extracellular matrix which produce ligand and signal stimulation that is occurred from the binding of ligand with epidermal growth factor receptor. In this paper, a mathematical model of signal transduction is investigated. Both signal and ligand are represented by Laplace equation with Dirichlet boundary condition for each region. The cell membrane is treated as free boundary surface to separate any activity that occurred in intracellular and extracellular regions. The motion of the interface is taken as gradient of nterior signal and the cell membrane is set as zero level set function. The problem is solved numerically using finite difference scheme of upwind, interpolation and extrapolation methods. The results showed that the formation of invadopodia is formed when protrusions exist on the cell membrane.
format Article
author Yaacob, Noorehan
Noor Azhuan, Nur Azura
Shafie, Sharidan
Admon, Mohd. Ariff
author_facet Yaacob, Noorehan
Noor Azhuan, Nur Azura
Shafie, Sharidan
Admon, Mohd. Ariff
author_sort Yaacob, Noorehan
title Numerical computation of signal stimulation from Ligand-EGFR binding during invadopodia formation
title_short Numerical computation of signal stimulation from Ligand-EGFR binding during invadopodia formation
title_full Numerical computation of signal stimulation from Ligand-EGFR binding during invadopodia formation
title_fullStr Numerical computation of signal stimulation from Ligand-EGFR binding during invadopodia formation
title_full_unstemmed Numerical computation of signal stimulation from Ligand-EGFR binding during invadopodia formation
title_sort numerical computation of signal stimulation from ligand-egfr binding during invadopodia formation
publisher Penerbit UTM Press
publishDate 2019
url http://eprints.utm.my/id/eprint/89446/
http://dx.doi.org/10.11113/matematika.v35.n4.1268
_version_ 1692991784995520512
score 13.211869

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