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Hydroxyapatite for poly(alpha-hydroxy esters) biocomposites applications

This article focuses on providing a systematic review on various fundamental properties of composite based on poly(α-hydroxy esters) and hydroxyapatite (HAp) for application in bone tissue engineering. Poly(α-hydroxy esters), a well-known synthetic biopolymer has attracted considerable interest to b...

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Main Authors: Ng, Hon Meng, Bee, Soo Tueen, Lee, Tin Sin, Ratnam, Chantara T., Rahmat, Abdul Razak
Format: Article
Published: Taylor and Francis Inc. 2019
Subjects:
TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/89406/
http://dx.doi.org/10.1080/15583724.2018.1488729
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spelling my.utm.894062021-02-22T06:04:35Z http://eprints.utm.my/id/eprint/89406/ Hydroxyapatite for poly(alpha-hydroxy esters) biocomposites applications Ng, Hon Meng Bee, Soo Tueen Lee, Tin Sin Ratnam, Chantara T. Rahmat, Abdul Razak TP Chemical technology This article focuses on providing a systematic review on various fundamental properties of composite based on poly(α-hydroxy esters) and hydroxyapatite (HAp) for application in bone tissue engineering. Poly(α-hydroxy esters), a well-known synthetic biopolymer has attracted considerable interest to be employed for synthesis of bone graft substitute material with HAp mainly due to its bioresorbability, variable biodegradation rate and melt-processibility. Such features are simultaneously attractive for both biomedical application and industrial-scale productions. Besides the main function of hydroxyapatite as bioactive ceramic filler in composite to induce new bone formation upon polymer bioresorption, HAp can also serve as reinforcement for matrix polymer by providing sufficient mechanical support for cell attachment. Moreover, HAp plays a significant role in determining other composite properties, such as resistance to ingress of body fluid, body temperature ageing, relaxation movement of polymer segment, and in vivo biodegradation. These properties constitute as the fundamental requirements in field of bone tissue regeneration which is desirable to be achieved by unique composite system based on poly(α-hydroxyesters) and HAp particles. Taylor and Francis Inc. 2019-04-03 Article PeerReviewed Ng, Hon Meng and Bee, Soo Tueen and Lee, Tin Sin and Ratnam, Chantara T. and Rahmat, Abdul Razak (2019) Hydroxyapatite for poly(alpha-hydroxy esters) biocomposites applications. Polymer Reviews, 59 (2). pp. 187-239. ISSN 1558-3724 http://dx.doi.org/10.1080/15583724.2018.1488729 DOI:10.1080/15583724.2018.1488729
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic TP Chemical technology
spellingShingle TP Chemical technology
Ng, Hon Meng
Bee, Soo Tueen
Lee, Tin Sin
Ratnam, Chantara T.
Rahmat, Abdul Razak
Hydroxyapatite for poly(alpha-hydroxy esters) biocomposites applications
description This article focuses on providing a systematic review on various fundamental properties of composite based on poly(α-hydroxy esters) and hydroxyapatite (HAp) for application in bone tissue engineering. Poly(α-hydroxy esters), a well-known synthetic biopolymer has attracted considerable interest to be employed for synthesis of bone graft substitute material with HAp mainly due to its bioresorbability, variable biodegradation rate and melt-processibility. Such features are simultaneously attractive for both biomedical application and industrial-scale productions. Besides the main function of hydroxyapatite as bioactive ceramic filler in composite to induce new bone formation upon polymer bioresorption, HAp can also serve as reinforcement for matrix polymer by providing sufficient mechanical support for cell attachment. Moreover, HAp plays a significant role in determining other composite properties, such as resistance to ingress of body fluid, body temperature ageing, relaxation movement of polymer segment, and in vivo biodegradation. These properties constitute as the fundamental requirements in field of bone tissue regeneration which is desirable to be achieved by unique composite system based on poly(α-hydroxyesters) and HAp particles.
format Article
author Ng, Hon Meng
Bee, Soo Tueen
Lee, Tin Sin
Ratnam, Chantara T.
Rahmat, Abdul Razak
author_facet Ng, Hon Meng
Bee, Soo Tueen
Lee, Tin Sin
Ratnam, Chantara T.
Rahmat, Abdul Razak
author_sort Ng, Hon Meng
title Hydroxyapatite for poly(alpha-hydroxy esters) biocomposites applications
title_short Hydroxyapatite for poly(alpha-hydroxy esters) biocomposites applications
title_full Hydroxyapatite for poly(alpha-hydroxy esters) biocomposites applications
title_fullStr Hydroxyapatite for poly(alpha-hydroxy esters) biocomposites applications
title_full_unstemmed Hydroxyapatite for poly(alpha-hydroxy esters) biocomposites applications
title_sort hydroxyapatite for poly(alpha-hydroxy esters) biocomposites applications
publisher Taylor and Francis Inc.
publishDate 2019
url http://eprints.utm.my/id/eprint/89406/
http://dx.doi.org/10.1080/15583724.2018.1488729
_version_ 1692991779083649024
score 13.211869

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