Staff View: Iron oxide nanoparticles improved biocompatibility and removal of middle molecule uremic toxin of polysulfone hollow fiber membranes

Iron oxide nanoparticles improved biocompatibility and removal of middle molecule uremic toxin of polysulfone hollow fiber membranes

Middle molecule uremic toxins constitute to a quarter of uremic toxins present in human blood. In a condition where these uremic toxins accumulate in bloodstream due to renal failure, blood purification process using a high performance membrane is required. Here, we develop biocompatible mixed matri...

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Main Authors:	Said, Noresah, Zainol Abidin, Muhammad Nidzhom, Hasbullah, Hasrinah, Ismail, Ahmad Fauzi, Goh, Pei Sean, Othman, Mohd. Hafiz Dzarfan, Abdullah, Mohd. Sohaimi, Ng, Be Cheer, Sheikh Abdul Kadir, Siti Hamimah, Kamal, Fatmawati
Format:	Article
Published:	John Wiley and Sons Inc. 2019
Subjects:	TP Chemical technology
Online Access:	http://eprints.utm.my/id/eprint/89296/ http://dx.doi.org/10.1002/app.48234
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id	my.utm.89296
record_format	eprints
spelling	my.utm.892962021-02-09T08:25:54Z http://eprints.utm.my/id/eprint/89296/ Iron oxide nanoparticles improved biocompatibility and removal of middle molecule uremic toxin of polysulfone hollow fiber membranes Said, Noresah Zainol Abidin, Muhammad Nidzhom Hasbullah, Hasrinah Ismail, Ahmad Fauzi Goh, Pei Sean Othman, Mohd. Hafiz Dzarfan Abdullah, Mohd. Sohaimi Ng, Be Cheer Sheikh Abdul Kadir, Siti Hamimah Kamal, Fatmawati TP Chemical technology Middle molecule uremic toxins constitute to a quarter of uremic toxins present in human blood. In a condition where these uremic toxins accumulate in bloodstream due to renal failure, blood purification process using a high performance membrane is required. Here, we develop biocompatible mixed matrix membranes (MMMs) made up of polysulfone (PSf) and iron oxide nanoparticles (Fe2O3 NPs) with the focus to remove middle molecule uremic toxin effectively. The MMMs were evaluated in terms of their biocompatibility and separation performance. At higher Fe2O3 NPs loading, the MMM displayed a huge reduction of protein adsorption and platelet adhesion while maintaining normal blood coagulation time and acceptable complement activation. The optimized MMM exhibited high permeability (110.47 L m−2 h−1 bar−1), protein retention (99.9%) and demonstrated excellent clearance of urea (82%) and lysozyme (46.7%). The PSf/Fe2O3 MMM is proven to have promising attributes for hemodialysis application. John Wiley and Sons Inc. 2019-12 Article PeerReviewed Said, Noresah and Zainol Abidin, Muhammad Nidzhom and Hasbullah, Hasrinah and Ismail, Ahmad Fauzi and Goh, Pei Sean and Othman, Mohd. Hafiz Dzarfan and Abdullah, Mohd. Sohaimi and Ng, Be Cheer and Sheikh Abdul Kadir, Siti Hamimah and Kamal, Fatmawati (2019) Iron oxide nanoparticles improved biocompatibility and removal of middle molecule uremic toxin of polysulfone hollow fiber membranes. Journal of Applied Polymer Science, 136 (48). p. 48234. ISSN 0021-8995 http://dx.doi.org/10.1002/app.48234
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
topic	TP Chemical technology
spellingShingle	TP Chemical technology Said, Noresah Zainol Abidin, Muhammad Nidzhom Hasbullah, Hasrinah Ismail, Ahmad Fauzi Goh, Pei Sean Othman, Mohd. Hafiz Dzarfan Abdullah, Mohd. Sohaimi Ng, Be Cheer Sheikh Abdul Kadir, Siti Hamimah Kamal, Fatmawati Iron oxide nanoparticles improved biocompatibility and removal of middle molecule uremic toxin of polysulfone hollow fiber membranes
description	Middle molecule uremic toxins constitute to a quarter of uremic toxins present in human blood. In a condition where these uremic toxins accumulate in bloodstream due to renal failure, blood purification process using a high performance membrane is required. Here, we develop biocompatible mixed matrix membranes (MMMs) made up of polysulfone (PSf) and iron oxide nanoparticles (Fe2O3 NPs) with the focus to remove middle molecule uremic toxin effectively. The MMMs were evaluated in terms of their biocompatibility and separation performance. At higher Fe2O3 NPs loading, the MMM displayed a huge reduction of protein adsorption and platelet adhesion while maintaining normal blood coagulation time and acceptable complement activation. The optimized MMM exhibited high permeability (110.47 L m−2 h−1 bar−1), protein retention (99.9%) and demonstrated excellent clearance of urea (82%) and lysozyme (46.7%). The PSf/Fe2O3 MMM is proven to have promising attributes for hemodialysis application.
format	Article
author	Said, Noresah Zainol Abidin, Muhammad Nidzhom Hasbullah, Hasrinah Ismail, Ahmad Fauzi Goh, Pei Sean Othman, Mohd. Hafiz Dzarfan Abdullah, Mohd. Sohaimi Ng, Be Cheer Sheikh Abdul Kadir, Siti Hamimah Kamal, Fatmawati
author_facet	Said, Noresah Zainol Abidin, Muhammad Nidzhom Hasbullah, Hasrinah Ismail, Ahmad Fauzi Goh, Pei Sean Othman, Mohd. Hafiz Dzarfan Abdullah, Mohd. Sohaimi Ng, Be Cheer Sheikh Abdul Kadir, Siti Hamimah Kamal, Fatmawati
author_sort	Said, Noresah
title	Iron oxide nanoparticles improved biocompatibility and removal of middle molecule uremic toxin of polysulfone hollow fiber membranes
title_short	Iron oxide nanoparticles improved biocompatibility and removal of middle molecule uremic toxin of polysulfone hollow fiber membranes
title_full	Iron oxide nanoparticles improved biocompatibility and removal of middle molecule uremic toxin of polysulfone hollow fiber membranes
title_fullStr	Iron oxide nanoparticles improved biocompatibility and removal of middle molecule uremic toxin of polysulfone hollow fiber membranes
title_full_unstemmed	Iron oxide nanoparticles improved biocompatibility and removal of middle molecule uremic toxin of polysulfone hollow fiber membranes
title_sort	iron oxide nanoparticles improved biocompatibility and removal of middle molecule uremic toxin of polysulfone hollow fiber membranes
publisher	John Wiley and Sons Inc.
publishDate	2019
url	http://eprints.utm.my/id/eprint/89296/ http://dx.doi.org/10.1002/app.48234
_version_	1692991768004395008
score	13.211869

Iron oxide nanoparticles improved biocompatibility and removal of middle molecule uremic toxin of polysulfone hollow fiber membranes

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