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Heat transfer analysis on progressive freeze concentration of aqueous lysozyme solution

In this study, operating conditions of progressive freeze concentration method were arranged to deal with heat transfer analysis. Progressive freeze concentration is also known as a method to remove water from the solution by freezing process. The aqueous solution of lysozyme needs a water removal t...

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Main Authors: Yahya, N., Aziz, N. S., Nasir, M. Z., Zakaria, Z. Y., Ngadi, N., Jusoh, M.
Format: Article
Published: Italian Association of Chemical Engineering - AIDIC 2019
Subjects:
TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/89205/
http://www.dx.doi.org/10.3303/CET197202
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spelling my.utm.892052021-02-09T02:37:39Z http://eprints.utm.my/id/eprint/89205/ Heat transfer analysis on progressive freeze concentration of aqueous lysozyme solution Yahya, N. Aziz, N. S. Nasir, M. Z. Zakaria, Z. Y. Ngadi, N. Jusoh, M. TP Chemical technology In this study, operating conditions of progressive freeze concentration method were arranged to deal with heat transfer analysis. Progressive freeze concentration is also known as a method to remove water from the solution by freezing process. The aqueous solution of lysozyme needs a water removal technology system as the residual moisture content has a significant impact on the solid-state stability of this biopharmaceutical product. The process was carried out by a newly designed crystallizer called a multiple probe cryo-concentrator (MPCC) which is completely equipped with a controlled stirrer, adjustable cooling gas system, solution tank and a set of cooling probes. The operating condition involved in this system include operation time, t (20 to 60 min), coolant temperature, CT (-6 to -14 C) and stirrer speed, SS (200 to 400 rpm) at constant initial concentration of 10mg/ml. The result of overall heat transfer coefficient (Uo) at varied operating condition was analysed and obtained where coolant temperature of -8 °C, operation time of 20 min and stirrer speed of 350 rpm were found to give the highest Uo. All the operating conditions were found to contribute to the progress of ice development and removal of water in the MPCC system resulting in purity of ice and solution concentration accordingly. Italian Association of Chemical Engineering - AIDIC 2019 Article PeerReviewed Yahya, N. and Aziz, N. S. and Nasir, M. Z. and Zakaria, Z. Y. and Ngadi, N. and Jusoh, M. (2019) Heat transfer analysis on progressive freeze concentration of aqueous lysozyme solution. Chemical Engineering Transactions, 72 . pp. 133-138. ISSN 2283-9216 http://www.dx.doi.org/10.3303/CET197202 DOI: 10.3303/CET197202
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic TP Chemical technology
spellingShingle TP Chemical technology
Yahya, N.
Aziz, N. S.
Nasir, M. Z.
Zakaria, Z. Y.
Ngadi, N.
Jusoh, M.
Heat transfer analysis on progressive freeze concentration of aqueous lysozyme solution
description In this study, operating conditions of progressive freeze concentration method were arranged to deal with heat transfer analysis. Progressive freeze concentration is also known as a method to remove water from the solution by freezing process. The aqueous solution of lysozyme needs a water removal technology system as the residual moisture content has a significant impact on the solid-state stability of this biopharmaceutical product. The process was carried out by a newly designed crystallizer called a multiple probe cryo-concentrator (MPCC) which is completely equipped with a controlled stirrer, adjustable cooling gas system, solution tank and a set of cooling probes. The operating condition involved in this system include operation time, t (20 to 60 min), coolant temperature, CT (-6 to -14 C) and stirrer speed, SS (200 to 400 rpm) at constant initial concentration of 10mg/ml. The result of overall heat transfer coefficient (Uo) at varied operating condition was analysed and obtained where coolant temperature of -8 °C, operation time of 20 min and stirrer speed of 350 rpm were found to give the highest Uo. All the operating conditions were found to contribute to the progress of ice development and removal of water in the MPCC system resulting in purity of ice and solution concentration accordingly.
format Article
author Yahya, N.
Aziz, N. S.
Nasir, M. Z.
Zakaria, Z. Y.
Ngadi, N.
Jusoh, M.
author_facet Yahya, N.
Aziz, N. S.
Nasir, M. Z.
Zakaria, Z. Y.
Ngadi, N.
Jusoh, M.
author_sort Yahya, N.
title Heat transfer analysis on progressive freeze concentration of aqueous lysozyme solution
title_short Heat transfer analysis on progressive freeze concentration of aqueous lysozyme solution
title_full Heat transfer analysis on progressive freeze concentration of aqueous lysozyme solution
title_fullStr Heat transfer analysis on progressive freeze concentration of aqueous lysozyme solution
title_full_unstemmed Heat transfer analysis on progressive freeze concentration of aqueous lysozyme solution
title_sort heat transfer analysis on progressive freeze concentration of aqueous lysozyme solution
publisher Italian Association of Chemical Engineering - AIDIC
publishDate 2019
url http://eprints.utm.my/id/eprint/89205/
http://www.dx.doi.org/10.3303/CET197202
_version_ 1691733081981976576
score 13.211869

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