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A dual-aggressive model of tumor-immune system interactions

Biomedical literature suggested that the tumor-immune system physical phenomenon usually climaxes into either tumor elimination or escape. In retort to the phenomenological mechanics of tumor-immune system interaction, researchers had used Mathematical models mostly prey-predator and competitive ext...

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Main Authors: Afolabi, Abdulkareem Ibrahim, Maan, Normah
格式: Article
語言:English
出版: Kassel University Press GmbH 2019
主題:
QA Mathematics
在線閱讀:http://eprints.utm.my/id/eprint/89082/1/NormahMaan2019_ADual-AggressiveModelofTumor-ImmuneSystemInteractions.pdf
http://eprints.utm.my/id/eprint/89082/
http://dx.doi.org/10.3991/ijoe.v15i10.10877
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spelling my.utm.890822021-01-26T08:44:22Z http://eprints.utm.my/id/eprint/89082/ A dual-aggressive model of tumor-immune system interactions Afolabi, Abdulkareem Ibrahim Maan, Normah QA Mathematics Biomedical literature suggested that the tumor-immune system physical phenomenon usually climaxes into either tumor elimination or escape. In retort to the phenomenological mechanics of tumor-immune system interaction, researchers had used Mathematical models mostly prey-predator and competitive extensively, to model the dynamics of tumor immune system interaction. However, these models had not accounted for total elimination and, or escape of tumor as hypothesizes by immunoediting hypotheses. In this work, we propose a dual aggressive model based on the biological narration of tumorimmune system interactions. The stability analyses of tumor-negative steady state are stable if the rate at which body cells dies is less than their proliferation rate a confirmation of biological listed causes of the tumor. The tumor-positive steady state is always unstable and saddle with the likelihood of either elimination or escape of tumor. Numerical analysis validates our analytical results and provides insight into the dynamics of the benignant and malignant tumor. The immunosuppression by tumor is not only visible but also validated by both analytical and numerical analysis. Kassel University Press GmbH 2019 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/89082/1/NormahMaan2019_ADual-AggressiveModelofTumor-ImmuneSystemInteractions.pdf Afolabi, Abdulkareem Ibrahim and Maan, Normah (2019) A dual-aggressive model of tumor-immune system interactions. International journal of online and biomedical engineering, 15 (10). pp. 155-161. ISSN 2626-8493 http://dx.doi.org/10.3991/ijoe.v15i10.10877
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic QA Mathematics
spellingShingle QA Mathematics
Afolabi, Abdulkareem Ibrahim
Maan, Normah
A dual-aggressive model of tumor-immune system interactions
description Biomedical literature suggested that the tumor-immune system physical phenomenon usually climaxes into either tumor elimination or escape. In retort to the phenomenological mechanics of tumor-immune system interaction, researchers had used Mathematical models mostly prey-predator and competitive extensively, to model the dynamics of tumor immune system interaction. However, these models had not accounted for total elimination and, or escape of tumor as hypothesizes by immunoediting hypotheses. In this work, we propose a dual aggressive model based on the biological narration of tumorimmune system interactions. The stability analyses of tumor-negative steady state are stable if the rate at which body cells dies is less than their proliferation rate a confirmation of biological listed causes of the tumor. The tumor-positive steady state is always unstable and saddle with the likelihood of either elimination or escape of tumor. Numerical analysis validates our analytical results and provides insight into the dynamics of the benignant and malignant tumor. The immunosuppression by tumor is not only visible but also validated by both analytical and numerical analysis.
format Article
author Afolabi, Abdulkareem Ibrahim
Maan, Normah
author_facet Afolabi, Abdulkareem Ibrahim
Maan, Normah
author_sort Afolabi, Abdulkareem Ibrahim
title A dual-aggressive model of tumor-immune system interactions
title_short A dual-aggressive model of tumor-immune system interactions
title_full A dual-aggressive model of tumor-immune system interactions
title_fullStr A dual-aggressive model of tumor-immune system interactions
title_full_unstemmed A dual-aggressive model of tumor-immune system interactions
title_sort dual-aggressive model of tumor-immune system interactions
publisher Kassel University Press GmbH
publishDate 2019
url http://eprints.utm.my/id/eprint/89082/1/NormahMaan2019_ADual-AggressiveModelofTumor-ImmuneSystemInteractions.pdf
http://eprints.utm.my/id/eprint/89082/
http://dx.doi.org/10.3991/ijoe.v15i10.10877
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score 13.250246

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