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Optimization of Plectranthus amboinicus (Lour.) Spreng Extraction Process using Microwave-Assisted Technique

Plectranthus amboinicus (Lour.) Spreng is a medicinal herb with bioactive compounds and known to have pharmacological properties. To obtain the extract of this herb, efficient extraction technique with high extraction rates is needed. Microwave-assisted extraction (MAE) is a green extraction techniq...

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Main Authors: Samad, N. A., Abang Zaidel, D. N., Salleh, E., Mohd. Yusof, A. H., Dailin, D. J., Abang Zaidel, D. K.
Format: Article
Published: Italian Association of Chemical Engineering - AIDIC 2019
Subjects:
TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/88767/
https://dx.doi.org/10.3303/CET1972067
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spelling my.utm.887672020-12-29T04:19:06Z http://eprints.utm.my/id/eprint/88767/ Optimization of Plectranthus amboinicus (Lour.) Spreng Extraction Process using Microwave-Assisted Technique Samad, N. A. Abang Zaidel, D. N. Salleh, E. Mohd. Yusof, A. H. Dailin, D. J. Abang Zaidel, D. K. TP Chemical technology Plectranthus amboinicus (Lour.) Spreng is a medicinal herb with bioactive compounds and known to have pharmacological properties. To obtain the extract of this herb, efficient extraction technique with high extraction rates is needed. Microwave-assisted extraction (MAE) is a green extraction technique with shorter irradiation time, less solvent used and lower CO2 emission compared to other conventional extraction methods. The objective of the study was to determine the optimum operating extraction condition of P. amboinicus using MAE by varying the irradiation time, solvent concentration and solvent-to-solid ratio to obtain optimum yield extract and conducted using response surface methodology (RSM). The extract obtained at optimum condition was characterized for its antioxidant properties. The RSM results show that the optimum condition of P. amboinicus extraction was at 2 min, 30 % ethanol concentration and solvent-to-solid ratio at 30 mL/g with yield extract obtained at 39.81 wt %. The result antioxidants activity of the P. amboinicus extract showed IC50 value of 4.63 mg/mL while the inhibition of DPPH radical scavenging activity from the trolox standard was 5.48 ± 0.77 mg trolox equivalents (TEQ)/g extract. The study proved MAE is a better alternative compared to conventional extraction method with 16.8 % higher yield and the extract of P. amboinicus can be potentially applied in healthcare and pharmaceutical industry. Italian Association of Chemical Engineering - AIDIC 2019 Article PeerReviewed Samad, N. A. and Abang Zaidel, D. N. and Salleh, E. and Mohd. Yusof, A. H. and Dailin, D. J. and Abang Zaidel, D. K. (2019) Optimization of Plectranthus amboinicus (Lour.) Spreng Extraction Process using Microwave-Assisted Technique. Chemical Engineering Transactions, 72 . pp. 397-402. ISSN 2283-9216 https://dx.doi.org/10.3303/CET1972067 DOI:10.3303/CET1972067
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic TP Chemical technology
spellingShingle TP Chemical technology
Samad, N. A.
Abang Zaidel, D. N.
Salleh, E.
Mohd. Yusof, A. H.
Dailin, D. J.
Abang Zaidel, D. K.
Optimization of Plectranthus amboinicus (Lour.) Spreng Extraction Process using Microwave-Assisted Technique
description Plectranthus amboinicus (Lour.) Spreng is a medicinal herb with bioactive compounds and known to have pharmacological properties. To obtain the extract of this herb, efficient extraction technique with high extraction rates is needed. Microwave-assisted extraction (MAE) is a green extraction technique with shorter irradiation time, less solvent used and lower CO2 emission compared to other conventional extraction methods. The objective of the study was to determine the optimum operating extraction condition of P. amboinicus using MAE by varying the irradiation time, solvent concentration and solvent-to-solid ratio to obtain optimum yield extract and conducted using response surface methodology (RSM). The extract obtained at optimum condition was characterized for its antioxidant properties. The RSM results show that the optimum condition of P. amboinicus extraction was at 2 min, 30 % ethanol concentration and solvent-to-solid ratio at 30 mL/g with yield extract obtained at 39.81 wt %. The result antioxidants activity of the P. amboinicus extract showed IC50 value of 4.63 mg/mL while the inhibition of DPPH radical scavenging activity from the trolox standard was 5.48 ± 0.77 mg trolox equivalents (TEQ)/g extract. The study proved MAE is a better alternative compared to conventional extraction method with 16.8 % higher yield and the extract of P. amboinicus can be potentially applied in healthcare and pharmaceutical industry.
format Article
author Samad, N. A.
Abang Zaidel, D. N.
Salleh, E.
Mohd. Yusof, A. H.
Dailin, D. J.
Abang Zaidel, D. K.
author_facet Samad, N. A.
Abang Zaidel, D. N.
Salleh, E.
Mohd. Yusof, A. H.
Dailin, D. J.
Abang Zaidel, D. K.
author_sort Samad, N. A.
title Optimization of Plectranthus amboinicus (Lour.) Spreng Extraction Process using Microwave-Assisted Technique
title_short Optimization of Plectranthus amboinicus (Lour.) Spreng Extraction Process using Microwave-Assisted Technique
title_full Optimization of Plectranthus amboinicus (Lour.) Spreng Extraction Process using Microwave-Assisted Technique
title_fullStr Optimization of Plectranthus amboinicus (Lour.) Spreng Extraction Process using Microwave-Assisted Technique
title_full_unstemmed Optimization of Plectranthus amboinicus (Lour.) Spreng Extraction Process using Microwave-Assisted Technique
title_sort optimization of plectranthus amboinicus (lour.) spreng extraction process using microwave-assisted technique
publisher Italian Association of Chemical Engineering - AIDIC
publishDate 2019
url http://eprints.utm.my/id/eprint/88767/
https://dx.doi.org/10.3303/CET1972067
_version_ 1687393618818498560
score 13.211869

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