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Physicochemical assessment of tailor made fibrous polyurethane scaffolds incorporated with turmeric oil for wound healing applications

Nanofibrous scaffold holds a great potential in remodeling of the damaged tissue. This work attempts to fabricate a fibrous wound dressing scaffold based on polyurethane (PU) mats reinforced with turmeric oil via electrospinning technique. The field emission electron microscopy (FESEM) depicted the...

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Main Authors: Jaganathan, Saravana Kumar, Mani, Mohan Prasath, Md. Khudzari, Ahmad Zahran, Ismail, Ahmad Fauzi
Format: Article
Published: Taylor and Francis Inc. 2019
Subjects:
Q Science (General)
Online Access:http://eprints.utm.my/id/eprint/88538/
http://dx.doi.org/10.1080/1023666X.2019.1676010
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spelling my.utm.885382020-12-15T00:19:48Z http://eprints.utm.my/id/eprint/88538/ Physicochemical assessment of tailor made fibrous polyurethane scaffolds incorporated with turmeric oil for wound healing applications Jaganathan, Saravana Kumar Mani, Mohan Prasath Md. Khudzari, Ahmad Zahran Ismail, Ahmad Fauzi Q Science (General) Nanofibrous scaffold holds a great potential in remodeling of the damaged tissue. This work attempts to fabricate a fibrous wound dressing scaffold based on polyurethane (PU) mats reinforced with turmeric oil via electrospinning technique. The field emission electron microscopy (FESEM) depicted the smaller fiber diameter of nanocomposites compared to polyurethane. Fourier transform infrared spectroscopy (FTIR) and thermal analyses insinuated the existence of turmeric in the PU matrix by the formation of hydrogen bond and reduced weight loss for composite scaffold. Contact angle of the PU scaffold showed a hydrophobic behavior while turmeric oil incorporation resulted in the hydrophilic nature. Atomic force microscopy (AFM) analysis showed a decrease in surface roughness of PU with the addition of turmeric oil. In blood compatibility results, the coagulation times were observed to the higher for PU/turmeric oil than PU. The developed nanocomposites showed a less percentage of lysis of red blood cells suggesting better blood compatibility than PU. Further, cell viability assay depicted enhanced proliferation of fibroblast cells in the developed composites than PU. Overall, it was concluded that fabricated novel scaffold having better physicochemical and good biocompatibility characteristics for wound dressing. Taylor and Francis Inc. 2019-11 Article PeerReviewed Jaganathan, Saravana Kumar and Mani, Mohan Prasath and Md. Khudzari, Ahmad Zahran and Ismail, Ahmad Fauzi (2019) Physicochemical assessment of tailor made fibrous polyurethane scaffolds incorporated with turmeric oil for wound healing applications. International Journal of Polymer Analysis and Characterization, 24 (8). pp. 752-762. ISSN 1023-666X http://dx.doi.org/10.1080/1023666X.2019.1676010
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic Q Science (General)
spellingShingle Q Science (General)
Jaganathan, Saravana Kumar
Mani, Mohan Prasath
Md. Khudzari, Ahmad Zahran
Ismail, Ahmad Fauzi
Physicochemical assessment of tailor made fibrous polyurethane scaffolds incorporated with turmeric oil for wound healing applications
description Nanofibrous scaffold holds a great potential in remodeling of the damaged tissue. This work attempts to fabricate a fibrous wound dressing scaffold based on polyurethane (PU) mats reinforced with turmeric oil via electrospinning technique. The field emission electron microscopy (FESEM) depicted the smaller fiber diameter of nanocomposites compared to polyurethane. Fourier transform infrared spectroscopy (FTIR) and thermal analyses insinuated the existence of turmeric in the PU matrix by the formation of hydrogen bond and reduced weight loss for composite scaffold. Contact angle of the PU scaffold showed a hydrophobic behavior while turmeric oil incorporation resulted in the hydrophilic nature. Atomic force microscopy (AFM) analysis showed a decrease in surface roughness of PU with the addition of turmeric oil. In blood compatibility results, the coagulation times were observed to the higher for PU/turmeric oil than PU. The developed nanocomposites showed a less percentage of lysis of red blood cells suggesting better blood compatibility than PU. Further, cell viability assay depicted enhanced proliferation of fibroblast cells in the developed composites than PU. Overall, it was concluded that fabricated novel scaffold having better physicochemical and good biocompatibility characteristics for wound dressing.
format Article
author Jaganathan, Saravana Kumar
Mani, Mohan Prasath
Md. Khudzari, Ahmad Zahran
Ismail, Ahmad Fauzi
author_facet Jaganathan, Saravana Kumar
Mani, Mohan Prasath
Md. Khudzari, Ahmad Zahran
Ismail, Ahmad Fauzi
author_sort Jaganathan, Saravana Kumar
title Physicochemical assessment of tailor made fibrous polyurethane scaffolds incorporated with turmeric oil for wound healing applications
title_short Physicochemical assessment of tailor made fibrous polyurethane scaffolds incorporated with turmeric oil for wound healing applications
title_full Physicochemical assessment of tailor made fibrous polyurethane scaffolds incorporated with turmeric oil for wound healing applications
title_fullStr Physicochemical assessment of tailor made fibrous polyurethane scaffolds incorporated with turmeric oil for wound healing applications
title_full_unstemmed Physicochemical assessment of tailor made fibrous polyurethane scaffolds incorporated with turmeric oil for wound healing applications
title_sort physicochemical assessment of tailor made fibrous polyurethane scaffolds incorporated with turmeric oil for wound healing applications
publisher Taylor and Francis Inc.
publishDate 2019
url http://eprints.utm.my/id/eprint/88538/
http://dx.doi.org/10.1080/1023666X.2019.1676010
_version_ 1687393585592270848
score 13.211869

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