Staff View: Hemodialysis performance and anticoagulant activities of PVP-k25 and carboxylic-multiwall nanotube composite blended Polyethersulfone membrane

Hemodialysis performance and anticoagulant activities of PVP-k25 and carboxylic-multiwall nanotube composite blended Polyethersulfone membrane

Non-covalent electrostatic interaction between amide nitrogen and carbonyl carbon of shorter chain length of polyvinylpyrrolidone (PVP-k25) was developed with in-house carboxylic oxidized multiwall carbon nanotubes (O-MWCNT) and then blended with Polyethersulfone (PES) polymer. FTIR analysis was uti...

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Main Authors:	Irfan, Muhammad, Irfan, Masooma, Shah, Syed Mazhar, Baig, Nadeem, Saleh, Tawfik A., Ahmed, Mahmood, Naz, Gul, Akhtar, Naeem, Muhammad, Nawshad, Idris, Ani
Format:	Article
Published:	Elsevier Ltd 2019
Subjects:	TP Chemical technology
Online Access:	http://eprints.utm.my/id/eprint/88266/ http://dx.doi.org/10.1016/j.msec.2019.109769
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spelling	my.utm.882662020-12-14T23:19:27Z http://eprints.utm.my/id/eprint/88266/ Hemodialysis performance and anticoagulant activities of PVP-k25 and carboxylic-multiwall nanotube composite blended Polyethersulfone membrane Irfan, Muhammad Irfan, Masooma Shah, Syed Mazhar Baig, Nadeem Saleh, Tawfik A. Ahmed, Mahmood Naz, Gul Akhtar, Naeem Muhammad, Nawshad Idris, Ani TP Chemical technology Non-covalent electrostatic interaction between amide nitrogen and carbonyl carbon of shorter chain length of polyvinylpyrrolidone (PVP-k25) was developed with in-house carboxylic oxidized multiwall carbon nanotubes (O-MWCNT) and then blended with Polyethersulfone (PES) polymer. FTIR analysis was utilized to confirm bonding nature of nano-composites (NCs) of O-MWCNT/PVP-k25 and casting membranes. Non-solvent induces phase separation process developed regular finger-like channels in composite membranes whereas pristine PES exhibited spongy entities as studied by cross sectional analysis report of FESEM. Further, FESEM instrument was also utilized to observe the dispersion of O-MWCNT/PVP based nanocomposite (NCs) with PES and membranes leaching phenomena analysis. Contact angle experiments described 24% improvement of hydrophilic behaviour, leaching ratio of additives was reduced to 1.89%, whereas water flux enhanced up to 6 times. Bovine serum albumin (BSA) and lysozyme based antifouling analysis shown up to 25% improvement, whereas 84% of water flux was regained after protein fouling than pristine PES. Anticoagulant activity was reported by estimating prothrombin, thrombin, plasma re-calcification times and production of fibrinogen cluster with platelets-adhesions photographs and hemolysis experiments. Composite membranes exhibited 3.4 and 3 times better dialysis clearance ratios of urea and creatinine solutes as compared to the raw PES membrane. Elsevier Ltd 2019-10 Article PeerReviewed Irfan, Muhammad and Irfan, Masooma and Shah, Syed Mazhar and Baig, Nadeem and Saleh, Tawfik A. and Ahmed, Mahmood and Naz, Gul and Akhtar, Naeem and Muhammad, Nawshad and Idris, Ani (2019) Hemodialysis performance and anticoagulant activities of PVP-k25 and carboxylic-multiwall nanotube composite blended Polyethersulfone membrane. Materials Science and Engineering C, 103 . p. 109769. ISSN 0928-4931 http://dx.doi.org/10.1016/j.msec.2019.109769
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
topic	TP Chemical technology
spellingShingle	TP Chemical technology Irfan, Muhammad Irfan, Masooma Shah, Syed Mazhar Baig, Nadeem Saleh, Tawfik A. Ahmed, Mahmood Naz, Gul Akhtar, Naeem Muhammad, Nawshad Idris, Ani Hemodialysis performance and anticoagulant activities of PVP-k25 and carboxylic-multiwall nanotube composite blended Polyethersulfone membrane
description	Non-covalent electrostatic interaction between amide nitrogen and carbonyl carbon of shorter chain length of polyvinylpyrrolidone (PVP-k25) was developed with in-house carboxylic oxidized multiwall carbon nanotubes (O-MWCNT) and then blended with Polyethersulfone (PES) polymer. FTIR analysis was utilized to confirm bonding nature of nano-composites (NCs) of O-MWCNT/PVP-k25 and casting membranes. Non-solvent induces phase separation process developed regular finger-like channels in composite membranes whereas pristine PES exhibited spongy entities as studied by cross sectional analysis report of FESEM. Further, FESEM instrument was also utilized to observe the dispersion of O-MWCNT/PVP based nanocomposite (NCs) with PES and membranes leaching phenomena analysis. Contact angle experiments described 24% improvement of hydrophilic behaviour, leaching ratio of additives was reduced to 1.89%, whereas water flux enhanced up to 6 times. Bovine serum albumin (BSA) and lysozyme based antifouling analysis shown up to 25% improvement, whereas 84% of water flux was regained after protein fouling than pristine PES. Anticoagulant activity was reported by estimating prothrombin, thrombin, plasma re-calcification times and production of fibrinogen cluster with platelets-adhesions photographs and hemolysis experiments. Composite membranes exhibited 3.4 and 3 times better dialysis clearance ratios of urea and creatinine solutes as compared to the raw PES membrane.
format	Article
author	Irfan, Muhammad Irfan, Masooma Shah, Syed Mazhar Baig, Nadeem Saleh, Tawfik A. Ahmed, Mahmood Naz, Gul Akhtar, Naeem Muhammad, Nawshad Idris, Ani
author_facet	Irfan, Muhammad Irfan, Masooma Shah, Syed Mazhar Baig, Nadeem Saleh, Tawfik A. Ahmed, Mahmood Naz, Gul Akhtar, Naeem Muhammad, Nawshad Idris, Ani
author_sort	Irfan, Muhammad
title	Hemodialysis performance and anticoagulant activities of PVP-k25 and carboxylic-multiwall nanotube composite blended Polyethersulfone membrane
title_short	Hemodialysis performance and anticoagulant activities of PVP-k25 and carboxylic-multiwall nanotube composite blended Polyethersulfone membrane
title_full	Hemodialysis performance and anticoagulant activities of PVP-k25 and carboxylic-multiwall nanotube composite blended Polyethersulfone membrane
title_fullStr	Hemodialysis performance and anticoagulant activities of PVP-k25 and carboxylic-multiwall nanotube composite blended Polyethersulfone membrane
title_full_unstemmed	Hemodialysis performance and anticoagulant activities of PVP-k25 and carboxylic-multiwall nanotube composite blended Polyethersulfone membrane
title_sort	hemodialysis performance and anticoagulant activities of pvp-k25 and carboxylic-multiwall nanotube composite blended polyethersulfone membrane
publisher	Elsevier Ltd
publishDate	2019
url	http://eprints.utm.my/id/eprint/88266/ http://dx.doi.org/10.1016/j.msec.2019.109769
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score	13.211869

Hemodialysis performance and anticoagulant activities of PVP-k25 and carboxylic-multiwall nanotube composite blended Polyethersulfone membrane

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