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Mixed matrix membrane tip extraction coupled with uplc-ms/ms for the monitoring of nonsteroidal anti-inflammatory drugs in water samples

An ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method, in combination with a mixed matrix membrane microextraction method for the quantification of nonsteroidal anti-inflammatory drugs (NSAIDs) in environmental water samples, is reported. The extraction device was p...

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Main Authors: Ganesan, T., Mukhtar, N. H., Lim, H. N., See, H. H.
Format: Article
Language:English
Published: MDPI 2020
Subjects:
QD Chemistry
Online Access:http://eprints.utm.my/id/eprint/88062/1/ThipashiniGanesan2020_MixedMatrixMembraneTipExtractionCoupled.pdf
http://eprints.utm.my/id/eprint/88062/
http://www.dx.doi.org/10.3390/separations7010019
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spelling my.utm.880622020-11-30T13:50:58Z http://eprints.utm.my/id/eprint/88062/ Mixed matrix membrane tip extraction coupled with uplc-ms/ms for the monitoring of nonsteroidal anti-inflammatory drugs in water samples Ganesan, T. Mukhtar, N. H. Lim, H. N. See, H. H. QD Chemistry An ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method, in combination with a mixed matrix membrane microextraction method for the quantification of nonsteroidal anti-inflammatory drugs (NSAIDs) in environmental water samples, is reported. The extraction device was prepared by casting well-dispersed polymeric bonded octadecyl (C18) particles in a cellulose triacetate matrix solution onto commercially available 200 µL micropipette tips. The membrane formed contains 25% of the adsorbent loading amount and was firmly attached to the inner wall of the membrane tip. The dynamic extraction was performed by withdrawing and dispensing the sample solution through the tip device for effective analyte adsorption, followed by the analyte desorption process into 40 µL of methanol and acetonitrile (1:1) prior to UPLC–MS/MS analysis. NSAIDs—namely diclofenac, ibuprofen, indoprofen, naproxen and sulindac—were chosen as targeted analytes. Several extraction parameters were comprehensively optimized, including sample pH value, ionic strength, dynamic extraction cycle, desorption solvent and desorption time. The optimized conditions demonstrated a linear range from 0.25 to 500 ng L−1, with correlation coefficients (r2) from 0.9988 to 0.9992 and detection limits ranging from 0.08 to 0.40 ng L−1. The recoveries of the spiked water samples were between 92% and 99% and exhibited excellent precision relative to standard deviations (RSDs ≤ 4.9%), and enrichment factors (EFs) were at 201–249 for the developed approach. MDPI 2020 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/88062/1/ThipashiniGanesan2020_MixedMatrixMembraneTipExtractionCoupled.pdf Ganesan, T. and Mukhtar, N. H. and Lim, H. N. and See, H. H. (2020) Mixed matrix membrane tip extraction coupled with uplc-ms/ms for the monitoring of nonsteroidal anti-inflammatory drugs in water samples. Separation, 7 (1). ISSN 2297-8739 http://www.dx.doi.org/10.3390/separations7010019 DOI: 10.3390/separations7010019
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Ganesan, T.
Mukhtar, N. H.
Lim, H. N.
See, H. H.
Mixed matrix membrane tip extraction coupled with uplc-ms/ms for the monitoring of nonsteroidal anti-inflammatory drugs in water samples
description An ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method, in combination with a mixed matrix membrane microextraction method for the quantification of nonsteroidal anti-inflammatory drugs (NSAIDs) in environmental water samples, is reported. The extraction device was prepared by casting well-dispersed polymeric bonded octadecyl (C18) particles in a cellulose triacetate matrix solution onto commercially available 200 µL micropipette tips. The membrane formed contains 25% of the adsorbent loading amount and was firmly attached to the inner wall of the membrane tip. The dynamic extraction was performed by withdrawing and dispensing the sample solution through the tip device for effective analyte adsorption, followed by the analyte desorption process into 40 µL of methanol and acetonitrile (1:1) prior to UPLC–MS/MS analysis. NSAIDs—namely diclofenac, ibuprofen, indoprofen, naproxen and sulindac—were chosen as targeted analytes. Several extraction parameters were comprehensively optimized, including sample pH value, ionic strength, dynamic extraction cycle, desorption solvent and desorption time. The optimized conditions demonstrated a linear range from 0.25 to 500 ng L−1, with correlation coefficients (r2) from 0.9988 to 0.9992 and detection limits ranging from 0.08 to 0.40 ng L−1. The recoveries of the spiked water samples were between 92% and 99% and exhibited excellent precision relative to standard deviations (RSDs ≤ 4.9%), and enrichment factors (EFs) were at 201–249 for the developed approach.
format Article
author Ganesan, T.
Mukhtar, N. H.
Lim, H. N.
See, H. H.
author_facet Ganesan, T.
Mukhtar, N. H.
Lim, H. N.
See, H. H.
author_sort Ganesan, T.
title Mixed matrix membrane tip extraction coupled with uplc-ms/ms for the monitoring of nonsteroidal anti-inflammatory drugs in water samples
title_short Mixed matrix membrane tip extraction coupled with uplc-ms/ms for the monitoring of nonsteroidal anti-inflammatory drugs in water samples
title_full Mixed matrix membrane tip extraction coupled with uplc-ms/ms for the monitoring of nonsteroidal anti-inflammatory drugs in water samples
title_fullStr Mixed matrix membrane tip extraction coupled with uplc-ms/ms for the monitoring of nonsteroidal anti-inflammatory drugs in water samples
title_full_unstemmed Mixed matrix membrane tip extraction coupled with uplc-ms/ms for the monitoring of nonsteroidal anti-inflammatory drugs in water samples
title_sort mixed matrix membrane tip extraction coupled with uplc-ms/ms for the monitoring of nonsteroidal anti-inflammatory drugs in water samples
publisher MDPI
publishDate 2020
url http://eprints.utm.my/id/eprint/88062/1/ThipashiniGanesan2020_MixedMatrixMembraneTipExtractionCoupled.pdf
http://eprints.utm.my/id/eprint/88062/
http://www.dx.doi.org/10.3390/separations7010019
_version_ 1685579022606532608
score 13.211869

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