Investigation of growth inhibitory effects of cyclo (n∝ -pyrido)-bis-[(l-valinyl)-lornthenyl acid hydrazide] on various cancer cells as well as in vitro vegfr-2 kinase inhibition
During the current work, we synthesized a new peptide derivative; 4,13-diisopropyl-2,5,12,15-tetraoxo-3,6,11,14-tetraaza-1(3,5)-pyridinacyclopentadecaphane-7-carbohydrazide. The prepared hydrazide was investigated for its in vivo as well as in vitro anticancer effects. Results revealed that this der...
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my.utm.877412020-11-30T13:15:30Z http://eprints.utm.my/id/eprint/87741/ Investigation of growth inhibitory effects of cyclo (n∝ -pyrido)-bis-[(l-valinyl)-lornthenyl acid hydrazide] on various cancer cells as well as in vitro vegfr-2 kinase inhibition Amr, A. E. Elsayed, E. A. Al-Omar, M. A. El-Enshasy, H. A. Q Science (General) During the current work, we synthesized a new peptide derivative; 4,13-diisopropyl-2,5,12,15-tetraoxo-3,6,11,14-tetraaza-1(3,5)-pyridinacyclopentadecaphane-7-carbohydrazide. The prepared hydrazide was investigated for its in vivo as well as in vitro anticancer effects. Results revealed that this derivative has a great potential against 6 cancerous cell lines. Furthermore, the highest effect was obtained against HT1080 and HeLa cells, where the compound showed 7.4- and 15.1-folds increased activity against them, respectively. Additionally, the compound seems to exert its potential anticancer effect by affecting the kinase enzyme VEGFR-2. Finally, the compound showed promising results when tested in in vivo against prostate cancer developed animal models. NISCAIR-CSIR, India 2020-04 Article PeerReviewed Amr, A. E. and Elsayed, E. A. and Al-Omar, M. A. and El-Enshasy, H. A. (2020) Investigation of growth inhibitory effects of cyclo (n∝ -pyrido)-bis-[(l-valinyl)-lornthenyl acid hydrazide] on various cancer cells as well as in vitro vegfr-2 kinase inhibition. Journal of Scientific and Industrial Research, 79 (4). pp. 328-332. ISSN 0022-4456 http://nopr.niscair.res.in/handle/123456789/54367 |
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Q Science (General) Amr, A. E. Elsayed, E. A. Al-Omar, M. A. El-Enshasy, H. A. Investigation of growth inhibitory effects of cyclo (n∝ -pyrido)-bis-[(l-valinyl)-lornthenyl acid hydrazide] on various cancer cells as well as in vitro vegfr-2 kinase inhibition |
| description |
During the current work, we synthesized a new peptide derivative; 4,13-diisopropyl-2,5,12,15-tetraoxo-3,6,11,14-tetraaza-1(3,5)-pyridinacyclopentadecaphane-7-carbohydrazide. The prepared hydrazide was investigated for its in vivo as well as in vitro anticancer effects. Results revealed that this derivative has a great potential against 6 cancerous cell lines. Furthermore, the highest effect was obtained against HT1080 and HeLa cells, where the compound showed 7.4- and 15.1-folds increased activity against them, respectively. Additionally, the compound seems to exert its potential anticancer effect by affecting the kinase enzyme VEGFR-2. Finally, the compound showed promising results when tested in in vivo against prostate cancer developed animal models. |
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Article |
| author |
Amr, A. E. Elsayed, E. A. Al-Omar, M. A. El-Enshasy, H. A. |
| author_facet |
Amr, A. E. Elsayed, E. A. Al-Omar, M. A. El-Enshasy, H. A. |
| author_sort |
Amr, A. E. |
| title |
Investigation of growth inhibitory effects of cyclo (n∝ -pyrido)-bis-[(l-valinyl)-lornthenyl acid hydrazide] on various cancer cells as well as in vitro vegfr-2 kinase inhibition |
| title_short |
Investigation of growth inhibitory effects of cyclo (n∝ -pyrido)-bis-[(l-valinyl)-lornthenyl acid hydrazide] on various cancer cells as well as in vitro vegfr-2 kinase inhibition |
| title_full |
Investigation of growth inhibitory effects of cyclo (n∝ -pyrido)-bis-[(l-valinyl)-lornthenyl acid hydrazide] on various cancer cells as well as in vitro vegfr-2 kinase inhibition |
| title_fullStr |
Investigation of growth inhibitory effects of cyclo (n∝ -pyrido)-bis-[(l-valinyl)-lornthenyl acid hydrazide] on various cancer cells as well as in vitro vegfr-2 kinase inhibition |
| title_full_unstemmed |
Investigation of growth inhibitory effects of cyclo (n∝ -pyrido)-bis-[(l-valinyl)-lornthenyl acid hydrazide] on various cancer cells as well as in vitro vegfr-2 kinase inhibition |
| title_sort |
investigation of growth inhibitory effects of cyclo (n∝ -pyrido)-bis-[(l-valinyl)-lornthenyl acid hydrazide] on various cancer cells as well as in vitro vegfr-2 kinase inhibition |
| publisher |
NISCAIR-CSIR, India |
| publishDate |
2020 |
| url |
http://eprints.utm.my/id/eprint/87741/ http://nopr.niscair.res.in/handle/123456789/54367 |
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1685578982283542528 |
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13.223943 |