Cover Image

Enhanced mechanical, thermal and biocompatible nature of dual component electrospun nanocomposite for bone tissue engineering

Traditionally, in the Asian continent, oils are a widely accepted choice for alleviating bone-related disorders. The design of scaffolds resembling the extracellular matrix (ECM) is of great significance in bone tissue engineering. In this study, a multicompo-nent polyurethane (PU), canola oil (CO)...

Full description

Saved in:
Bibliographic Details
Main Authors: Li, Guanbao, Li, Pinquan, Chen, Qiuan, Mani, Mohan Prasath, Jaganathan, Saravana Kumar
Format: Article
Published: PeerJ Inc. 2019
Subjects:
QP Physiology
Online Access:http://eprints.utm.my/id/eprint/87696/
http://dx.doi.org/10.7717/peerj.6986
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.utm.87696
record_format eprints
spelling my.utm.876962020-11-30T13:08:57Z http://eprints.utm.my/id/eprint/87696/ Enhanced mechanical, thermal and biocompatible nature of dual component electrospun nanocomposite for bone tissue engineering Li, Guanbao Li, Pinquan Chen, Qiuan Mani, Mohan Prasath Jaganathan, Saravana Kumar QP Physiology Traditionally, in the Asian continent, oils are a widely accepted choice for alleviating bone-related disorders. The design of scaffolds resembling the extracellular matrix (ECM) is of great significance in bone tissue engineering. In this study, a multicompo-nent polyurethane (PU), canola oil (CO) and neem oil (NO) scaffold was developed using the electrospinning technique. The fabricated nanofibers were subjected to various physicochemical and biological testing to validate its suitability for bone tissue engineering. Morphological analysis of the multicomponent scaffold showed a reduc-Tion in fiber diameter (PU/CO 853 141.27 nm and PU/CO/NO 633 137.54 nm) compared to PU (890 116.911 nm). The existence of CO and NO in PU matrix was confirmed by an infrared spectrum (IR) with the formation of hydrogen bond. PU/CO displayed a mean contact angle of 108.7 0.58 while the PU/CO/NO exhibited hydrophilic nature with an angle of 62.33 2.52. The developed multicomponent also exhibited higher thermal stability and increased mechanical strength compared to the pristine PU. Atomic force microscopy (AFM) analysis depicted lower surface roughness for the nanocomposites (PU/CO 389 nm and PU/CO/NO 323 nm) than the pristine PU (576 nm). Blood compatibility investigation displayed the anticoagulant nature of the composites. Cytocompatibility studies revealed the non-Toxic nature of the developed composites with human fibroblast cells (HDF) cells. The newly developed porous PU nanocomposite scaffold comprising CO and NO may serve as a potential candidate for bone tissue engineering. PeerJ Inc. 2019 Article PeerReviewed Li, Guanbao and Li, Pinquan and Chen, Qiuan and Mani, Mohan Prasath and Jaganathan, Saravana Kumar (2019) Enhanced mechanical, thermal and biocompatible nature of dual component electrospun nanocomposite for bone tissue engineering. PeerJ, 2019 (5). e6986-e6986. ISSN 2167-8359 http://dx.doi.org/10.7717/peerj.6986
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic QP Physiology
spellingShingle QP Physiology
Li, Guanbao
Li, Pinquan
Chen, Qiuan
Mani, Mohan Prasath
Jaganathan, Saravana Kumar
Enhanced mechanical, thermal and biocompatible nature of dual component electrospun nanocomposite for bone tissue engineering
description Traditionally, in the Asian continent, oils are a widely accepted choice for alleviating bone-related disorders. The design of scaffolds resembling the extracellular matrix (ECM) is of great significance in bone tissue engineering. In this study, a multicompo-nent polyurethane (PU), canola oil (CO) and neem oil (NO) scaffold was developed using the electrospinning technique. The fabricated nanofibers were subjected to various physicochemical and biological testing to validate its suitability for bone tissue engineering. Morphological analysis of the multicomponent scaffold showed a reduc-Tion in fiber diameter (PU/CO 853 141.27 nm and PU/CO/NO 633 137.54 nm) compared to PU (890 116.911 nm). The existence of CO and NO in PU matrix was confirmed by an infrared spectrum (IR) with the formation of hydrogen bond. PU/CO displayed a mean contact angle of 108.7 0.58 while the PU/CO/NO exhibited hydrophilic nature with an angle of 62.33 2.52. The developed multicomponent also exhibited higher thermal stability and increased mechanical strength compared to the pristine PU. Atomic force microscopy (AFM) analysis depicted lower surface roughness for the nanocomposites (PU/CO 389 nm and PU/CO/NO 323 nm) than the pristine PU (576 nm). Blood compatibility investigation displayed the anticoagulant nature of the composites. Cytocompatibility studies revealed the non-Toxic nature of the developed composites with human fibroblast cells (HDF) cells. The newly developed porous PU nanocomposite scaffold comprising CO and NO may serve as a potential candidate for bone tissue engineering.
format Article
author Li, Guanbao
Li, Pinquan
Chen, Qiuan
Mani, Mohan Prasath
Jaganathan, Saravana Kumar
author_facet Li, Guanbao
Li, Pinquan
Chen, Qiuan
Mani, Mohan Prasath
Jaganathan, Saravana Kumar
author_sort Li, Guanbao
title Enhanced mechanical, thermal and biocompatible nature of dual component electrospun nanocomposite for bone tissue engineering
title_short Enhanced mechanical, thermal and biocompatible nature of dual component electrospun nanocomposite for bone tissue engineering
title_full Enhanced mechanical, thermal and biocompatible nature of dual component electrospun nanocomposite for bone tissue engineering
title_fullStr Enhanced mechanical, thermal and biocompatible nature of dual component electrospun nanocomposite for bone tissue engineering
title_full_unstemmed Enhanced mechanical, thermal and biocompatible nature of dual component electrospun nanocomposite for bone tissue engineering
title_sort enhanced mechanical, thermal and biocompatible nature of dual component electrospun nanocomposite for bone tissue engineering
publisher PeerJ Inc.
publishDate 2019
url http://eprints.utm.my/id/eprint/87696/
http://dx.doi.org/10.7717/peerj.6986
_version_ 1685578975470944256
score 13.211869

Similar Items