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Anti-vegfr-2 kinase effects of cyclo (n-a-dinicotinoyl)-bis-[(l-valinyl)-l-lysine] and its anticancer activities against different cancer cell lines

The current work aimed at preparing a cyclo (N-a-dinicotinoyl)-bis-[(L-valinyl)-L-lysine] from previously established synthetic routs. The derivative was investigated for its potential anticancer activities as well as its possible mechanism of action. The prepared compound showed variable anticancer...

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Main Authors: Amr, A. E., Elsayed, E. A., Al-Omar, M. A., El-Enshasy, H. A.
Format: Article
Published: Natl Inst Science Communication-Niscair 2020
Subjects:
Q Science (General)
Online Access:http://eprints.utm.my/id/eprint/87635/
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spelling my.utm.876352020-11-30T09:06:29Z http://eprints.utm.my/id/eprint/87635/ Anti-vegfr-2 kinase effects of cyclo (n-a-dinicotinoyl)-bis-[(l-valinyl)-l-lysine] and its anticancer activities against different cancer cell lines Amr, A. E. Elsayed, E. A. Al-Omar, M. A. El-Enshasy, H. A. Q Science (General) The current work aimed at preparing a cyclo (N-a-dinicotinoyl)-bis-[(L-valinyl)-L-lysine] from previously established synthetic routs. The derivative was investigated for its potential anticancer activities as well as its possible mechanism of action. The prepared compound showed variable anticancer activities against all tested cell lines. Furthermore, it showed very promising activities in terms of obtained IC50 values compared to known used drugs. The mechanism of action studies showed that the prepared tripeptide may act on cancerous cells through its inhibitory action on tyrosine kinase pathway. Animal model experiments proved the potential of the synthesized tripeptide as an anticancer agent against PC3 cancer cells. Natl Inst Science Communication-Niscair 2020-05 Article PeerReviewed Amr, A. E. and Elsayed, E. A. and Al-Omar, M. A. and El-Enshasy, H. A. (2020) Anti-vegfr-2 kinase effects of cyclo (n-a-dinicotinoyl)-bis-[(l-valinyl)-l-lysine] and its anticancer activities against different cancer cell lines. Journal of Scientific & Industrial Research, 79 (5). pp. 413-417. http://apps.webofknowledge.com.ezproxy.utm.my/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=C66YlcAeJnjo947Qha6&page=1&doc=1
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic Q Science (General)
spellingShingle Q Science (General)
Amr, A. E.
Elsayed, E. A.
Al-Omar, M. A.
El-Enshasy, H. A.
Anti-vegfr-2 kinase effects of cyclo (n-a-dinicotinoyl)-bis-[(l-valinyl)-l-lysine] and its anticancer activities against different cancer cell lines
description The current work aimed at preparing a cyclo (N-a-dinicotinoyl)-bis-[(L-valinyl)-L-lysine] from previously established synthetic routs. The derivative was investigated for its potential anticancer activities as well as its possible mechanism of action. The prepared compound showed variable anticancer activities against all tested cell lines. Furthermore, it showed very promising activities in terms of obtained IC50 values compared to known used drugs. The mechanism of action studies showed that the prepared tripeptide may act on cancerous cells through its inhibitory action on tyrosine kinase pathway. Animal model experiments proved the potential of the synthesized tripeptide as an anticancer agent against PC3 cancer cells.
format Article
author Amr, A. E.
Elsayed, E. A.
Al-Omar, M. A.
El-Enshasy, H. A.
author_facet Amr, A. E.
Elsayed, E. A.
Al-Omar, M. A.
El-Enshasy, H. A.
author_sort Amr, A. E.
title Anti-vegfr-2 kinase effects of cyclo (n-a-dinicotinoyl)-bis-[(l-valinyl)-l-lysine] and its anticancer activities against different cancer cell lines
title_short Anti-vegfr-2 kinase effects of cyclo (n-a-dinicotinoyl)-bis-[(l-valinyl)-l-lysine] and its anticancer activities against different cancer cell lines
title_full Anti-vegfr-2 kinase effects of cyclo (n-a-dinicotinoyl)-bis-[(l-valinyl)-l-lysine] and its anticancer activities against different cancer cell lines
title_fullStr Anti-vegfr-2 kinase effects of cyclo (n-a-dinicotinoyl)-bis-[(l-valinyl)-l-lysine] and its anticancer activities against different cancer cell lines
title_full_unstemmed Anti-vegfr-2 kinase effects of cyclo (n-a-dinicotinoyl)-bis-[(l-valinyl)-l-lysine] and its anticancer activities against different cancer cell lines
title_sort anti-vegfr-2 kinase effects of cyclo (n-a-dinicotinoyl)-bis-[(l-valinyl)-l-lysine] and its anticancer activities against different cancer cell lines
publisher Natl Inst Science Communication-Niscair
publishDate 2020
url http://eprints.utm.my/id/eprint/87635/
http://apps.webofknowledge.com.ezproxy.utm.my/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=C66YlcAeJnjo947Qha6&page=1&doc=1
_version_ 1685578966243475456
score 13.223943

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