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Partitioning behaviour of selected antibiotics in organic solvents

The commercial production of antibiotics today uses the solvent extraction method in the extraction of antibiotics. Selection of solvent in any solvent extraction process is crucial due to technical and economic reasons. In order to get better understanding on the effect of solvent on the partitioni...

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Main Authors:	Mohd. Setapar, Siti Hamidah, Lau, S. W., Yong, C., Chen, P. L., Shanjingm, Y., Mat, Hanapi
Format:	Article
Language:	English
Published:	Faculty of Chemical Engineering & Natural Resources 2008
Subjects:	TP Chemical technology
Online Access:	http://eprints.utm.my/id/eprint/8692/1/SHMohdSetapar2008_PartitioningBehaviourOfSelectedAntibiotics.pdf http://eprints.utm.my/id/eprint/8692/ http://www.fkkksa.utm.my/jcnre/
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spelling	my.utm.86922017-10-23T08:06:17Z http://eprints.utm.my/id/eprint/8692/ Partitioning behaviour of selected antibiotics in organic solvents Mohd. Setapar, Siti Hamidah Lau, S. W. Yong, C. Chen, P. L. Shanjingm, Y. Mat, Hanapi TP Chemical technology The commercial production of antibiotics today uses the solvent extraction method in the extraction of antibiotics. Selection of solvent in any solvent extraction process is crucial due to technical and economic reasons. In order to get better understanding on the effect of solvent on the partitioning behaviour antibiotics, selected antibiotics such as kitasamycin, penicillin G, rifampicin and teicoplanin from aqueous buffer solution were studied using various groups of organic solvents such as alcohols, aldehydes, ketones, aliphatic hydrocarbons, kerosene and paraffin, as well as with addition of various extractants in kerosene system in order to enhance solute partitioning. The effects of solvent polarity, pH, antibiotic types and extractant addition on the partitioning behaviour of antibiotics were investigated. The polarity of solvents, in general, increases with an increase in solubility parameter and dielectric constant; and with a decrease in log P. Different groups of organic solvents exhibit different solvent polarity scales. Among them, alcohols are the most favourable solvent group for the partition of antibiotics, followed by aldehydes and ketones. Meanwhile antibiotic types such as kitasamycin and rifampicin displayed a very high degree of partitioning especially for solvent groups of alcohol, aldehyde and ketone over the pH range. On the other hand, addition of the extractant, TOMAC in kerosene displayed excellent partitioning efficiency for all the antibiotics used except kitasamycin whereas AOT was the next superb extractant in kerosene system for all except penicillin G. Faculty of Chemical Engineering & Natural Resources 2008 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/8692/1/SHMohdSetapar2008_PartitioningBehaviourOfSelectedAntibiotics.pdf Mohd. Setapar, Siti Hamidah and Lau, S. W. and Yong, C. and Chen, P. L. and Shanjingm, Y. and Mat, Hanapi (2008) Partitioning behaviour of selected antibiotics in organic solvents. Journal of Chemical and Natural Resources Engineering, 2 (Specia). pp. 100-112. ISSN 1823-5255 http://www.fkkksa.utm.my/jcnre/
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Mohd. Setapar, Siti Hamidah Lau, S. W. Yong, C. Chen, P. L. Shanjingm, Y. Mat, Hanapi Partitioning behaviour of selected antibiotics in organic solvents
description	The commercial production of antibiotics today uses the solvent extraction method in the extraction of antibiotics. Selection of solvent in any solvent extraction process is crucial due to technical and economic reasons. In order to get better understanding on the effect of solvent on the partitioning behaviour antibiotics, selected antibiotics such as kitasamycin, penicillin G, rifampicin and teicoplanin from aqueous buffer solution were studied using various groups of organic solvents such as alcohols, aldehydes, ketones, aliphatic hydrocarbons, kerosene and paraffin, as well as with addition of various extractants in kerosene system in order to enhance solute partitioning. The effects of solvent polarity, pH, antibiotic types and extractant addition on the partitioning behaviour of antibiotics were investigated. The polarity of solvents, in general, increases with an increase in solubility parameter and dielectric constant; and with a decrease in log P. Different groups of organic solvents exhibit different solvent polarity scales. Among them, alcohols are the most favourable solvent group for the partition of antibiotics, followed by aldehydes and ketones. Meanwhile antibiotic types such as kitasamycin and rifampicin displayed a very high degree of partitioning especially for solvent groups of alcohol, aldehyde and ketone over the pH range. On the other hand, addition of the extractant, TOMAC in kerosene displayed excellent partitioning efficiency for all the antibiotics used except kitasamycin whereas AOT was the next superb extractant in kerosene system for all except penicillin G.
format	Article
author	Mohd. Setapar, Siti Hamidah Lau, S. W. Yong, C. Chen, P. L. Shanjingm, Y. Mat, Hanapi
author_facet	Mohd. Setapar, Siti Hamidah Lau, S. W. Yong, C. Chen, P. L. Shanjingm, Y. Mat, Hanapi
author_sort	Mohd. Setapar, Siti Hamidah
title	Partitioning behaviour of selected antibiotics in organic solvents
title_short	Partitioning behaviour of selected antibiotics in organic solvents
title_full	Partitioning behaviour of selected antibiotics in organic solvents
title_fullStr	Partitioning behaviour of selected antibiotics in organic solvents
title_full_unstemmed	Partitioning behaviour of selected antibiotics in organic solvents
title_sort	partitioning behaviour of selected antibiotics in organic solvents
publisher	Faculty of Chemical Engineering & Natural Resources
publishDate	2008
url	http://eprints.utm.my/id/eprint/8692/1/SHMohdSetapar2008_PartitioningBehaviourOfSelectedAntibiotics.pdf http://eprints.utm.my/id/eprint/8692/ http://www.fkkksa.utm.my/jcnre/
_version_	1643645047498866688
score	13.211869

Partitioning behaviour of selected antibiotics in organic solvents

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