Staff View: Overview of bile acids signaling and perspective on the signal of ursodeoxycholic acid, the most hydrophilic bile acid, in the heart

Overview of bile acids signaling and perspective on the signal of ursodeoxycholic acid, the most hydrophilic bile acid, in the heart

Bile acids (BA) are classically known as an important agent in lipid absorption and cholesterol metabolism. Nowadays, their role in glucose regulation and energy homeostasis are widely reported. BAs are involved in various cellular signaling pathways, such as protein kinase cascades, cyclic AMP (cAM...

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Main Authors:	Hanafi, Noorul Izzati, Mohamed, Anis Syamimi, Abdul Kadir, Siti Hamimah Sheikh, Othman, Mohd. Hafiz Dzarfan
Format:	Article
Language:	English
Published:	MDPI AG 2018
Subjects:	TP Chemical technology
Online Access:	http://eprints.utm.my/id/eprint/86286/1/MohdHafizDzarfan2018_OverviewofBileAcidsSignalingandPerspective.pdf http://eprints.utm.my/id/eprint/86286/ http://dx.doi.org/10.3390/biom8040159
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spelling	my.utm.862862020-08-31T13:57:27Z http://eprints.utm.my/id/eprint/86286/ Overview of bile acids signaling and perspective on the signal of ursodeoxycholic acid, the most hydrophilic bile acid, in the heart Hanafi, Noorul Izzati Mohamed, Anis Syamimi Abdul Kadir, Siti Hamimah Sheikh Othman, Mohd. Hafiz Dzarfan TP Chemical technology Bile acids (BA) are classically known as an important agent in lipid absorption and cholesterol metabolism. Nowadays, their role in glucose regulation and energy homeostasis are widely reported. BAs are involved in various cellular signaling pathways, such as protein kinase cascades, cyclic AMP (cAMP) synthesis, and calcium mobilization. They are ligands for several nuclear hormone receptors, including farnesoid X-receptor (FXR). Recently, BAs have been shown to bind to muscarinic receptor and Takeda G-protein-coupled receptor 5 (TGR5), both G-protein-coupled receptor (GPCR), independent of the nuclear hormone receptors. Moreover, BA signals have also been elucidated in other nonclassical BA pathways, such as sphingosine-1-posphate and BK (large conductance calcium-and voltage activated potassium) channels. Hydrophobic BAs have been proven to affect heart rate and its contraction. Elevated BAs are associated with arrhythmias in adults and fetal heart, and altered ratios of primary and secondary bile acid are reported in chronic heart failure patients. Meanwhile, in patients with liver cirrhosis, cardiac dysfunction has been strongly linked to the increase in serum bile acid concentrations. In contrast, the most hydrophilic BA, known as ursodeoxycholic acid (UDCA), has been found to be beneficial in improving peripheral blood flow in chronic heart failure patients and in protecting the heart against reperfusion injury. This review provides an overview of BA signaling, with the main emphasis on past and present perspectives on UDCA signals in the heart. MDPI AG 2018-12 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/86286/1/MohdHafizDzarfan2018_OverviewofBileAcidsSignalingandPerspective.pdf Hanafi, Noorul Izzati and Mohamed, Anis Syamimi and Abdul Kadir, Siti Hamimah Sheikh and Othman, Mohd. Hafiz Dzarfan (2018) Overview of bile acids signaling and perspective on the signal of ursodeoxycholic acid, the most hydrophilic bile acid, in the heart. Biomolecules, 8 (4). pp. 159-1. ISSN 2218-273X http://dx.doi.org/10.3390/biom8040159 DOI:10.3390/biom8040159
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Hanafi, Noorul Izzati Mohamed, Anis Syamimi Abdul Kadir, Siti Hamimah Sheikh Othman, Mohd. Hafiz Dzarfan Overview of bile acids signaling and perspective on the signal of ursodeoxycholic acid, the most hydrophilic bile acid, in the heart
description	Bile acids (BA) are classically known as an important agent in lipid absorption and cholesterol metabolism. Nowadays, their role in glucose regulation and energy homeostasis are widely reported. BAs are involved in various cellular signaling pathways, such as protein kinase cascades, cyclic AMP (cAMP) synthesis, and calcium mobilization. They are ligands for several nuclear hormone receptors, including farnesoid X-receptor (FXR). Recently, BAs have been shown to bind to muscarinic receptor and Takeda G-protein-coupled receptor 5 (TGR5), both G-protein-coupled receptor (GPCR), independent of the nuclear hormone receptors. Moreover, BA signals have also been elucidated in other nonclassical BA pathways, such as sphingosine-1-posphate and BK (large conductance calcium-and voltage activated potassium) channels. Hydrophobic BAs have been proven to affect heart rate and its contraction. Elevated BAs are associated with arrhythmias in adults and fetal heart, and altered ratios of primary and secondary bile acid are reported in chronic heart failure patients. Meanwhile, in patients with liver cirrhosis, cardiac dysfunction has been strongly linked to the increase in serum bile acid concentrations. In contrast, the most hydrophilic BA, known as ursodeoxycholic acid (UDCA), has been found to be beneficial in improving peripheral blood flow in chronic heart failure patients and in protecting the heart against reperfusion injury. This review provides an overview of BA signaling, with the main emphasis on past and present perspectives on UDCA signals in the heart.
format	Article
author	Hanafi, Noorul Izzati Mohamed, Anis Syamimi Abdul Kadir, Siti Hamimah Sheikh Othman, Mohd. Hafiz Dzarfan
author_facet	Hanafi, Noorul Izzati Mohamed, Anis Syamimi Abdul Kadir, Siti Hamimah Sheikh Othman, Mohd. Hafiz Dzarfan
author_sort	Hanafi, Noorul Izzati
title	Overview of bile acids signaling and perspective on the signal of ursodeoxycholic acid, the most hydrophilic bile acid, in the heart
title_short	Overview of bile acids signaling and perspective on the signal of ursodeoxycholic acid, the most hydrophilic bile acid, in the heart
title_full	Overview of bile acids signaling and perspective on the signal of ursodeoxycholic acid, the most hydrophilic bile acid, in the heart
title_fullStr	Overview of bile acids signaling and perspective on the signal of ursodeoxycholic acid, the most hydrophilic bile acid, in the heart
title_full_unstemmed	Overview of bile acids signaling and perspective on the signal of ursodeoxycholic acid, the most hydrophilic bile acid, in the heart
title_sort	overview of bile acids signaling and perspective on the signal of ursodeoxycholic acid, the most hydrophilic bile acid, in the heart
publisher	MDPI AG
publishDate	2018
url	http://eprints.utm.my/id/eprint/86286/1/MohdHafizDzarfan2018_OverviewofBileAcidsSignalingandPerspective.pdf http://eprints.utm.my/id/eprint/86286/ http://dx.doi.org/10.3390/biom8040159
_version_	1677781156214341632
score	13.211869

Overview of bile acids signaling and perspective on the signal of ursodeoxycholic acid, the most hydrophilic bile acid, in the heart

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