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Particle depositions in multi stage liquid impinger as simplified lung model using computational fluid dynamic

Inhaled medication is typically used to treat obstructive pulmonary disease and systemic diseases. The effectiveness of pulmonary drug delivery depends on the amount of drug deposited beyond the oropharyngeal region, the place where the deposition and the uniform distribution occurred. In this study...

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Main Author: Azmi, Musfirah
Format: Thesis
Language:English
Published: 2019
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TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/86068/1/MusfirahAzmiMSChE2019.pdf
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spelling my.utm.860682020-08-30T08:53:19Z http://eprints.utm.my/id/eprint/86068/ Particle depositions in multi stage liquid impinger as simplified lung model using computational fluid dynamic Azmi, Musfirah TP Chemical technology Inhaled medication is typically used to treat obstructive pulmonary disease and systemic diseases. The effectiveness of pulmonary drug delivery depends on the amount of drug deposited beyond the oropharyngeal region, the place where the deposition and the uniform distribution occurred. In this study, the performance of multistage liquid impinger (MSLI) simplified model which imitates the physiological lung in delivering the drug was analyzed. In order to achieve this main aim, the airflow patterns and particle depositions efficiency were evaluated in MSLI simplified model using computational fluid dynamic of COMSOL® software. The particle deposition efficiency is studied by varying flowrates (30.0 L/min, 60.0 L/min and 100.0 L/min) and particle sizes (0.1, 1.0, 3.0, 5.0, 10.0 pm) of salbutamol sulphate (density 20.0 kg/m3). The highest particle deposition occurred at flowrate 100.0 L/min and particle size of 1.0 pm as the deposition yield was 15.55% compared to flowrate 60 L/min and 30 L/min which were 10.50% and 3.09% respectively. Previous studies claimed that higher inhalation flowrate generated dispersion forces for sufficient inhalation flowrate thus enhanced higher deposition efficiency. The paired-samples T-test shows there were significant different (t= -15.400, df= 4, p <0.05) in the performance of particle depositions in MSLI simplified model with different flow rates (60.0 L/min and 100.0 L/min). Thus, the efficient fine particle deposition was significantly contributed by higher flowrate. This study also revealed that particle size ranges from 1.0 to 3.0 pm was the most suitable for inhalation treatment. Smaller particle size less than 1.0 pm was not suitable as it tended to exhale before it deposit of while larger particle (more than 5.0 pm) was not suitable for inhaled drug. In conclusion, vigorous air flow pattern promotes higher particle deposition. For efficient fine particle depositions, it is important to consider not only the particle size distribution, but also the flowrate as vital aerosol transportation agent. Statistical analysis, two-way ANOVA indicated that there was a statistically significant interaction between the effect of flowrate and particle size on particle deposition efficiency, F (8, 30)=5.857, p=0.00. 2019 Thesis NonPeerReviewed application/pdf en http://eprints.utm.my/id/eprint/86068/1/MusfirahAzmiMSChE2019.pdf Azmi, Musfirah (2019) Particle depositions in multi stage liquid impinger as simplified lung model using computational fluid dynamic. Masters thesis, Universiti Teknologi Malaysia, Faculty of Engineering - School of Chemical & Energy Engineering. http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:131577
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Azmi, Musfirah
Particle depositions in multi stage liquid impinger as simplified lung model using computational fluid dynamic
description Inhaled medication is typically used to treat obstructive pulmonary disease and systemic diseases. The effectiveness of pulmonary drug delivery depends on the amount of drug deposited beyond the oropharyngeal region, the place where the deposition and the uniform distribution occurred. In this study, the performance of multistage liquid impinger (MSLI) simplified model which imitates the physiological lung in delivering the drug was analyzed. In order to achieve this main aim, the airflow patterns and particle depositions efficiency were evaluated in MSLI simplified model using computational fluid dynamic of COMSOL® software. The particle deposition efficiency is studied by varying flowrates (30.0 L/min, 60.0 L/min and 100.0 L/min) and particle sizes (0.1, 1.0, 3.0, 5.0, 10.0 pm) of salbutamol sulphate (density 20.0 kg/m3). The highest particle deposition occurred at flowrate 100.0 L/min and particle size of 1.0 pm as the deposition yield was 15.55% compared to flowrate 60 L/min and 30 L/min which were 10.50% and 3.09% respectively. Previous studies claimed that higher inhalation flowrate generated dispersion forces for sufficient inhalation flowrate thus enhanced higher deposition efficiency. The paired-samples T-test shows there were significant different (t= -15.400, df= 4, p <0.05) in the performance of particle depositions in MSLI simplified model with different flow rates (60.0 L/min and 100.0 L/min). Thus, the efficient fine particle deposition was significantly contributed by higher flowrate. This study also revealed that particle size ranges from 1.0 to 3.0 pm was the most suitable for inhalation treatment. Smaller particle size less than 1.0 pm was not suitable as it tended to exhale before it deposit of while larger particle (more than 5.0 pm) was not suitable for inhaled drug. In conclusion, vigorous air flow pattern promotes higher particle deposition. For efficient fine particle depositions, it is important to consider not only the particle size distribution, but also the flowrate as vital aerosol transportation agent. Statistical analysis, two-way ANOVA indicated that there was a statistically significant interaction between the effect of flowrate and particle size on particle deposition efficiency, F (8, 30)=5.857, p=0.00.
format Thesis
author Azmi, Musfirah
author_facet Azmi, Musfirah
author_sort Azmi, Musfirah
title Particle depositions in multi stage liquid impinger as simplified lung model using computational fluid dynamic
title_short Particle depositions in multi stage liquid impinger as simplified lung model using computational fluid dynamic
title_full Particle depositions in multi stage liquid impinger as simplified lung model using computational fluid dynamic
title_fullStr Particle depositions in multi stage liquid impinger as simplified lung model using computational fluid dynamic
title_full_unstemmed Particle depositions in multi stage liquid impinger as simplified lung model using computational fluid dynamic
title_sort particle depositions in multi stage liquid impinger as simplified lung model using computational fluid dynamic
publishDate 2019
url http://eprints.utm.my/id/eprint/86068/1/MusfirahAzmiMSChE2019.pdf
http://eprints.utm.my/id/eprint/86068/
http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:131577
_version_ 1677781125908398080
score 13.211869

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