Cover Image

Characterization of poly(vinyl alcohol)- polycaprolactone hybridized scaffold for potential skin tissue regeneration

The fabrication of a hybridized scaffold constituting hydrophobic and hydrophilic polymers for tissue engineering has received an increasing attention recently. Due to the high compatibility with water, a hydrophilic polymer, though is able to enhance cell affinity and proliferation, has a very high...

Full description

Saved in:
Bibliographic Details
Main Authors: Tan, Yong Chee, Mohd. Yusoff, Abdull Rahim, Nik Malek, Nik Ahmad Nizam
Format: Article
Language:English
Published: Penerbit UTM Press 2020
Subjects:
QD Chemistry
Online Access:http://eprints.utm.my/id/eprint/85562/1/AbdullRahimMohdYusoff2020_CharacterizationofPoly%28VinylAlcohol%29Polycaprolactone.pdf
http://eprints.utm.my/id/eprint/85562/
https://mjfas.utm.my/index.php/mjfas/article/view/1469
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.utm.85562
record_format eprints
spelling my.utm.855622020-06-30T08:50:34Z http://eprints.utm.my/id/eprint/85562/ Characterization of poly(vinyl alcohol)- polycaprolactone hybridized scaffold for potential skin tissue regeneration Tan, Yong Chee Mohd. Yusoff, Abdull Rahim Nik Malek, Nik Ahmad Nizam QD Chemistry The fabrication of a hybridized scaffold constituting hydrophobic and hydrophilic polymers for tissue engineering has received an increasing attention recently. Due to the high compatibility with water, a hydrophilic polymer, though is able to enhance cell affinity and proliferation, has a very high biodegradable rate and low stability in aqueous medium that eventually puncture its biomedical applications. Thereby, the addition of a hydrophobic polymer in the hydrophilic polymer scaffold is recommended to increase the hydrophobic property of the scaffold in order to reduce the limitation. Nonetheless, the fabrication of the hybridized scaffold is extremely challenging because the hydrophilic and the hydrophobic polymer tends to dissolve in different types of solvents, i.e. water and organic solvent, respectively, that subsequently restricts their blending process. In this work, a poly(vinyl alcohol) (PVA) scaffold, a polycaprolactone (PCL) scaffold, and their hybridized scaffold were produced through casting method for potential skin tissue regeneration. We found that the glacial acetic acid was an appropriate solvent used to prepare hydrophobic PCL solution with low molecular weight (16 kDa) for PCL-PVA blend, with mass ratio 1:1, without using any surfactant. The solvent was also used for the preparation of PCL scaffold with high molecular weight (80 kDa). The fabricated polymer scaffolds were then evaluated using FTIR-ATR, contact angle measurement, and tensile strength analysis. FESEM images of the PVA-PCL hybridized scaffold showed that the PCL was well dispersed in the PVA scaffold. FTIR-ATR spectra showed that the hybridized scaffold exhibited the crucial functional group of PVA and PCL at 3310.97, 1720.10, 1557.80, 1241.69, 1172.90, 1044.95, and 719.44 cm-1. The contact angle of the PVA, PCL, and PVA-PCL hybridized scaffold were 61.3o, 82.7o, and 75.9o, respectively, with tensile strength 16.5747, 2.4038, and 7.417 MPa, respectively. Penerbit UTM Press 2020 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/85562/1/AbdullRahimMohdYusoff2020_CharacterizationofPoly%28VinylAlcohol%29Polycaprolactone.pdf Tan, Yong Chee and Mohd. Yusoff, Abdull Rahim and Nik Malek, Nik Ahmad Nizam (2020) Characterization of poly(vinyl alcohol)- polycaprolactone hybridized scaffold for potential skin tissue regeneration. Malaysian Journal of Fundamental and Applied Sciences, 16 (1). pp. 6-9. ISSN 2289-5981 https://mjfas.utm.my/index.php/mjfas/article/view/1469
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Tan, Yong Chee
Mohd. Yusoff, Abdull Rahim
Nik Malek, Nik Ahmad Nizam
Characterization of poly(vinyl alcohol)- polycaprolactone hybridized scaffold for potential skin tissue regeneration
description The fabrication of a hybridized scaffold constituting hydrophobic and hydrophilic polymers for tissue engineering has received an increasing attention recently. Due to the high compatibility with water, a hydrophilic polymer, though is able to enhance cell affinity and proliferation, has a very high biodegradable rate and low stability in aqueous medium that eventually puncture its biomedical applications. Thereby, the addition of a hydrophobic polymer in the hydrophilic polymer scaffold is recommended to increase the hydrophobic property of the scaffold in order to reduce the limitation. Nonetheless, the fabrication of the hybridized scaffold is extremely challenging because the hydrophilic and the hydrophobic polymer tends to dissolve in different types of solvents, i.e. water and organic solvent, respectively, that subsequently restricts their blending process. In this work, a poly(vinyl alcohol) (PVA) scaffold, a polycaprolactone (PCL) scaffold, and their hybridized scaffold were produced through casting method for potential skin tissue regeneration. We found that the glacial acetic acid was an appropriate solvent used to prepare hydrophobic PCL solution with low molecular weight (16 kDa) for PCL-PVA blend, with mass ratio 1:1, without using any surfactant. The solvent was also used for the preparation of PCL scaffold with high molecular weight (80 kDa). The fabricated polymer scaffolds were then evaluated using FTIR-ATR, contact angle measurement, and tensile strength analysis. FESEM images of the PVA-PCL hybridized scaffold showed that the PCL was well dispersed in the PVA scaffold. FTIR-ATR spectra showed that the hybridized scaffold exhibited the crucial functional group of PVA and PCL at 3310.97, 1720.10, 1557.80, 1241.69, 1172.90, 1044.95, and 719.44 cm-1. The contact angle of the PVA, PCL, and PVA-PCL hybridized scaffold were 61.3o, 82.7o, and 75.9o, respectively, with tensile strength 16.5747, 2.4038, and 7.417 MPa, respectively.
format Article
author Tan, Yong Chee
Mohd. Yusoff, Abdull Rahim
Nik Malek, Nik Ahmad Nizam
author_facet Tan, Yong Chee
Mohd. Yusoff, Abdull Rahim
Nik Malek, Nik Ahmad Nizam
author_sort Tan, Yong Chee
title Characterization of poly(vinyl alcohol)- polycaprolactone hybridized scaffold for potential skin tissue regeneration
title_short Characterization of poly(vinyl alcohol)- polycaprolactone hybridized scaffold for potential skin tissue regeneration
title_full Characterization of poly(vinyl alcohol)- polycaprolactone hybridized scaffold for potential skin tissue regeneration
title_fullStr Characterization of poly(vinyl alcohol)- polycaprolactone hybridized scaffold for potential skin tissue regeneration
title_full_unstemmed Characterization of poly(vinyl alcohol)- polycaprolactone hybridized scaffold for potential skin tissue regeneration
title_sort characterization of poly(vinyl alcohol)- polycaprolactone hybridized scaffold for potential skin tissue regeneration
publisher Penerbit UTM Press
publishDate 2020
url http://eprints.utm.my/id/eprint/85562/1/AbdullRahimMohdYusoff2020_CharacterizationofPoly%28VinylAlcohol%29Polycaprolactone.pdf
http://eprints.utm.my/id/eprint/85562/
https://mjfas.utm.my/index.php/mjfas/article/view/1469
_version_ 1672610551977476096
score 13.211869

Similar Items