Molecular dynamics simulations suggest changes in electrostatic interactions as a potential mechanism through which serine phosphorylation inhibits DNA polymerase β activity
DNA polymerase β is a 39 kDa enzyme that is a major component of Base Excision Repair in human cells. The enzyme comprises two major domains, a 31 kDa domain responsible for the polymerase activity and an 8 kDa domain, which bind ssDNA and has a deoxyribose phosphate (dRP) lyase activity. DNA polyme...
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| Main Authors: | , , , , |
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| Format: | Article |
| Published: |
Elsevier Inc.
2018
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| Subjects: | |
| Online Access: | http://eprints.utm.my/id/eprint/85466/ http://dx.doi.org/10.1016/j.jmgm.2018.08.007 |
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