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Ultrasmall superparamagnetic Fe3O4 nanoparticles: honey-based green and facile synthesis and in vitro viability assay

Introduction: In the present research, we report a quick and green synthesis of magnetite nanoparticles (Fe3O4-NPs) in aqueous solution using ferric and ferrous chloride, with different percentages of natural honey (0.5%, 1.0%, 3.0% and 5.0% w/v) as the precursors, stabilizer, reducing and capping a...

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Main Authors:	Rasouli, Elisa, Basirun, Wan Jeffrey, Rezayi, Majid, Shameli, Kamyar, Nourmohammadi, Esmail, Khandanlou, Roshanak, Izadiyan, Zahra, Sarkarizi, Hoda Khoshdel
Format:	Article
Published:	Dove Press Ltd 2018
Subjects:	TP Chemical technology
Online Access:	http://eprints.utm.my/id/eprint/85287/ http://dx.doi.org/10.2147/IJN.S158083
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spelling	my.utm.852872020-03-17T08:04:39Z http://eprints.utm.my/id/eprint/85287/ Ultrasmall superparamagnetic Fe3O4 nanoparticles: honey-based green and facile synthesis and in vitro viability assay Rasouli, Elisa Basirun, Wan Jeffrey Rezayi, Majid Shameli, Kamyar Nourmohammadi, Esmail Khandanlou, Roshanak Izadiyan, Zahra Sarkarizi, Hoda Khoshdel TP Chemical technology Introduction: In the present research, we report a quick and green synthesis of magnetite nanoparticles (Fe3O4-NPs) in aqueous solution using ferric and ferrous chloride, with different percentages of natural honey (0.5%, 1.0%, 3.0% and 5.0% w/v) as the precursors, stabilizer, reducing and capping agent, respectively. The effect of the stabilizer on the magnetic properties and size of Fe3O4-NPs was also studied. Methods: The nanoparticles were characterized by X-ray diffraction (XRD) analysis, field emission scanning electron microscopy, energy dispersive X-ray fluorescence, transmission electron microscopy (TEM), vibrating sample magnetometry (VSM) and Fourier transform infrared spectroscopy. Results: The XRD analysis indicated the presence of pure Fe3O4-NPs while the TEM images indicated that the Fe3O4-NPs are spherical with a diameter range between 3.21 and 2.22 nm. The VSM study demonstrated that the magnetic properties were enhanced with the decrease in the percentage of honey. In vitro viability evaluation of Fe3O4-NPs performed by using the MTT assay on the WEHI164 cells demonstrated no significant toxicity in higher concentration up to 140.0 ppm, which allows them to be used in some biological applications such as drug delivery. Conclusion: The presented synthesis method can be used for the controlled synthesis of Fe3O4-NPs, which could be found to be important in applications in biotechnology, biosensor and biomedicine, magnetic resonance imaging and catalysis. Dove Press Ltd 2018-10-26 Article PeerReviewed Rasouli, Elisa and Basirun, Wan Jeffrey and Rezayi, Majid and Shameli, Kamyar and Nourmohammadi, Esmail and Khandanlou, Roshanak and Izadiyan, Zahra and Sarkarizi, Hoda Khoshdel (2018) Ultrasmall superparamagnetic Fe3O4 nanoparticles: honey-based green and facile synthesis and in vitro viability assay. International Journal of Nanomedicine, 13 . pp. 6903-6911. ISSN 1178-2013 http://dx.doi.org/10.2147/IJN.S158083 DOI:10.2147/IJN.S158083
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
topic	TP Chemical technology
spellingShingle	TP Chemical technology Rasouli, Elisa Basirun, Wan Jeffrey Rezayi, Majid Shameli, Kamyar Nourmohammadi, Esmail Khandanlou, Roshanak Izadiyan, Zahra Sarkarizi, Hoda Khoshdel Ultrasmall superparamagnetic Fe3O4 nanoparticles: honey-based green and facile synthesis and in vitro viability assay
description	Introduction: In the present research, we report a quick and green synthesis of magnetite nanoparticles (Fe3O4-NPs) in aqueous solution using ferric and ferrous chloride, with different percentages of natural honey (0.5%, 1.0%, 3.0% and 5.0% w/v) as the precursors, stabilizer, reducing and capping agent, respectively. The effect of the stabilizer on the magnetic properties and size of Fe3O4-NPs was also studied. Methods: The nanoparticles were characterized by X-ray diffraction (XRD) analysis, field emission scanning electron microscopy, energy dispersive X-ray fluorescence, transmission electron microscopy (TEM), vibrating sample magnetometry (VSM) and Fourier transform infrared spectroscopy. Results: The XRD analysis indicated the presence of pure Fe3O4-NPs while the TEM images indicated that the Fe3O4-NPs are spherical with a diameter range between 3.21 and 2.22 nm. The VSM study demonstrated that the magnetic properties were enhanced with the decrease in the percentage of honey. In vitro viability evaluation of Fe3O4-NPs performed by using the MTT assay on the WEHI164 cells demonstrated no significant toxicity in higher concentration up to 140.0 ppm, which allows them to be used in some biological applications such as drug delivery. Conclusion: The presented synthesis method can be used for the controlled synthesis of Fe3O4-NPs, which could be found to be important in applications in biotechnology, biosensor and biomedicine, magnetic resonance imaging and catalysis.
format	Article
author	Rasouli, Elisa Basirun, Wan Jeffrey Rezayi, Majid Shameli, Kamyar Nourmohammadi, Esmail Khandanlou, Roshanak Izadiyan, Zahra Sarkarizi, Hoda Khoshdel
author_facet	Rasouli, Elisa Basirun, Wan Jeffrey Rezayi, Majid Shameli, Kamyar Nourmohammadi, Esmail Khandanlou, Roshanak Izadiyan, Zahra Sarkarizi, Hoda Khoshdel
author_sort	Rasouli, Elisa
title	Ultrasmall superparamagnetic Fe3O4 nanoparticles: honey-based green and facile synthesis and in vitro viability assay
title_short	Ultrasmall superparamagnetic Fe3O4 nanoparticles: honey-based green and facile synthesis and in vitro viability assay
title_full	Ultrasmall superparamagnetic Fe3O4 nanoparticles: honey-based green and facile synthesis and in vitro viability assay
title_fullStr	Ultrasmall superparamagnetic Fe3O4 nanoparticles: honey-based green and facile synthesis and in vitro viability assay
title_full_unstemmed	Ultrasmall superparamagnetic Fe3O4 nanoparticles: honey-based green and facile synthesis and in vitro viability assay
title_sort	ultrasmall superparamagnetic fe3o4 nanoparticles: honey-based green and facile synthesis and in vitro viability assay
publisher	Dove Press Ltd
publishDate	2018
url	http://eprints.utm.my/id/eprint/85287/ http://dx.doi.org/10.2147/IJN.S158083
_version_	1662754377988833280
score	13.211869

Ultrasmall superparamagnetic Fe3O4 nanoparticles: honey-based green and facile synthesis and in vitro viability assay

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