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Anticonvulsant studies on the isolated compounds from the leaves of Scurrula parasitica L (Loranthaceae)

The leaves of Scurrula parasitica were effectively extracted by means of cold extraction method. Fractionation and purification of the n-hexane, ethyl acetate, and methanol crude extracts yielded eight compounds. These compounds were identified as quercetin (1), quercitrin (2), kaempferol 3-O--L-rh...

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Main Authors: Muhammad, Kamal Ja’afar, Jamil, Shajarahtunnur, Basar, Norazah, Magaji, Mohammed Garba
Format: Article
Language:English
Published: Penerbit UTM Press 2019
Subjects:
QD Chemistry
Online Access:http://eprints.utm.my/id/eprint/85063/1/ShajarahtunnurJamil2019_AnticonvulsantStudiesontheIsolatedCompounds.pdf
http://eprints.utm.my/id/eprint/85063/
https://mjfas.utm.my/index.php/mjfas/article/download/1375/pdf
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spelling my.utm.850632020-03-04T02:17:13Z http://eprints.utm.my/id/eprint/85063/ Anticonvulsant studies on the isolated compounds from the leaves of Scurrula parasitica L (Loranthaceae) Muhammad, Kamal Ja’afar Jamil, Shajarahtunnur Basar, Norazah Magaji, Mohammed Garba QD Chemistry The leaves of Scurrula parasitica were effectively extracted by means of cold extraction method. Fractionation and purification of the n-hexane, ethyl acetate, and methanol crude extracts yielded eight compounds. These compounds were identified as quercetin (1), quercitrin (2), kaempferol 3-O--L-rhamnoside (3), (+)-catechin (4), lupeol (5), lupeol palmitate (6), -sitosterol (7), and squalene(8). Compounds 1, 4, 5, and 6 were investigated for anticonvulsant potentials using maximalelectroshock test (MEST) in chicks and pentylenetetrazole-induced seizure test in mice while theeffect of the compounds on motor coordination was investigated using beam walking assay. Thecompounds did not completely protect the mice against pentylenetetrazole-induced seizure, butincreased the mean onset of myoclonic jerks and spasms in the animals. Quercetin (1) significantly (p< 0.05) increased the mean onset of spasm in the unprotected animals. The compounds alsodifferentially protected the mice against mortality. Conversely, the compounds did not protect thechick against the MEST. Similarly, they did not significantly reduce the recovery time. In the beamwalking assay, the increase in the number of foot slips observed in the study may be associated withthe interaction of quercetin (1) and (+)-catechin (4) with the GABA system to produce clinicalsedation. The findings of the present study suggest that the isolated compounds possess some mildanticonvulsant potential and may be beneficial in the management of petit mal epilepsy. Penerbit UTM Press 2019 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/85063/1/ShajarahtunnurJamil2019_AnticonvulsantStudiesontheIsolatedCompounds.pdf Muhammad, Kamal Ja’afar and Jamil, Shajarahtunnur and Basar, Norazah and Magaji, Mohammed Garba (2019) Anticonvulsant studies on the isolated compounds from the leaves of Scurrula parasitica L (Loranthaceae). Malaysian Journal of Fundamental and Applied Sciences, 15 (6). pp. 806-810. ISSN 2289-5981 https://mjfas.utm.my/index.php/mjfas/article/download/1375/pdf
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Muhammad, Kamal Ja’afar
Jamil, Shajarahtunnur
Basar, Norazah
Magaji, Mohammed Garba
Anticonvulsant studies on the isolated compounds from the leaves of Scurrula parasitica L (Loranthaceae)
description The leaves of Scurrula parasitica were effectively extracted by means of cold extraction method. Fractionation and purification of the n-hexane, ethyl acetate, and methanol crude extracts yielded eight compounds. These compounds were identified as quercetin (1), quercitrin (2), kaempferol 3-O--L-rhamnoside (3), (+)-catechin (4), lupeol (5), lupeol palmitate (6), -sitosterol (7), and squalene(8). Compounds 1, 4, 5, and 6 were investigated for anticonvulsant potentials using maximalelectroshock test (MEST) in chicks and pentylenetetrazole-induced seizure test in mice while theeffect of the compounds on motor coordination was investigated using beam walking assay. Thecompounds did not completely protect the mice against pentylenetetrazole-induced seizure, butincreased the mean onset of myoclonic jerks and spasms in the animals. Quercetin (1) significantly (p< 0.05) increased the mean onset of spasm in the unprotected animals. The compounds alsodifferentially protected the mice against mortality. Conversely, the compounds did not protect thechick against the MEST. Similarly, they did not significantly reduce the recovery time. In the beamwalking assay, the increase in the number of foot slips observed in the study may be associated withthe interaction of quercetin (1) and (+)-catechin (4) with the GABA system to produce clinicalsedation. The findings of the present study suggest that the isolated compounds possess some mildanticonvulsant potential and may be beneficial in the management of petit mal epilepsy.
format Article
author Muhammad, Kamal Ja’afar
Jamil, Shajarahtunnur
Basar, Norazah
Magaji, Mohammed Garba
author_facet Muhammad, Kamal Ja’afar
Jamil, Shajarahtunnur
Basar, Norazah
Magaji, Mohammed Garba
author_sort Muhammad, Kamal Ja’afar
title Anticonvulsant studies on the isolated compounds from the leaves of Scurrula parasitica L (Loranthaceae)
title_short Anticonvulsant studies on the isolated compounds from the leaves of Scurrula parasitica L (Loranthaceae)
title_full Anticonvulsant studies on the isolated compounds from the leaves of Scurrula parasitica L (Loranthaceae)
title_fullStr Anticonvulsant studies on the isolated compounds from the leaves of Scurrula parasitica L (Loranthaceae)
title_full_unstemmed Anticonvulsant studies on the isolated compounds from the leaves of Scurrula parasitica L (Loranthaceae)
title_sort anticonvulsant studies on the isolated compounds from the leaves of scurrula parasitica l (loranthaceae)
publisher Penerbit UTM Press
publishDate 2019
url http://eprints.utm.my/id/eprint/85063/1/ShajarahtunnurJamil2019_AnticonvulsantStudiesontheIsolatedCompounds.pdf
http://eprints.utm.my/id/eprint/85063/
https://mjfas.utm.my/index.php/mjfas/article/download/1375/pdf
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score 13.211869

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