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Single stage electrospun multicomponent scaffold for bone tissue engineering application

Incorporation of oils in to the polymer matrix results in the improvement of physicochemical and biocompatible properties. A novel polyurethane based composite bone scaffold was fabricated by electrospinning using sunflower and neem oil for the first time. Scanning electron microscopy (SEM) revealed...

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Main Authors: Jaganathan, Saravana Kumar, Mani, Mohan Prasath, Nageswaran, Gomathi, Krishnasamy, Navaneetha Pandiyaraj, Ayyar, Manikandan
Format: Article
Published: Elsevier Ltd 2018
Subjects:
QH301 Biology
Online Access:http://eprints.utm.my/id/eprint/84571/
http://dx.doi.org/10.1016/j.polymertesting.2018.07.015
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spelling my.utm.845712020-02-27T03:05:32Z http://eprints.utm.my/id/eprint/84571/ Single stage electrospun multicomponent scaffold for bone tissue engineering application Jaganathan, Saravana Kumar Mani, Mohan Prasath Nageswaran, Gomathi Krishnasamy, Navaneetha Pandiyaraj Ayyar, Manikandan QH301 Biology Incorporation of oils in to the polymer matrix results in the improvement of physicochemical and biocompatible properties. A novel polyurethane based composite bone scaffold was fabricated by electrospinning using sunflower and neem oil for the first time. Scanning electron microscopy (SEM) revealed the mean fiber diameter of the electrospun nanocomposite was decreased with the addition of sunflower oil (816 ± 129.54 nm) and sunflower/neem oil (739 ± 130.922 nm) into the PU matrix (890 ± 116.9115 nm). The strong interactions between PU, sunflower oil and neem oil were observed through Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA). Contact angle analysis depicted the hydrophobic (PU/sunflower oil - 112° ± 1) nature and with the incorporation of neem oil it shifted to hydrophilic (PU/sunflower oil/neem oil - 61.67° ± 2.517) behavior. Further, the tensile strength analysis showed the improvement in the mechanical strength with the addition of sunflower oil (10.62 MPa) and sunflower/neem oil (11.67 MPa) in to the PU matrix (7.12 MPa). In addition, the developed composites exhibited reduced hemolytic index percentage and enhanced blood clotting time through coagulation studies. Moreover, the cytocompatibility investigation revealed the non-toxic nature of the fabricated nanocomposites with human dermal fibroblast (HDF) cells than the pristine PU. Hence, the developed PU based composites rendering better physio-chemical and cytocompatible properties can serve as an alternate substitute for bone tissue engineering applications. Elsevier Ltd 2018-09 Article PeerReviewed Jaganathan, Saravana Kumar and Mani, Mohan Prasath and Nageswaran, Gomathi and Krishnasamy, Navaneetha Pandiyaraj and Ayyar, Manikandan (2018) Single stage electrospun multicomponent scaffold for bone tissue engineering application. Polymer Testing, 70 . pp. 244-254. ISSN 0142-9418 http://dx.doi.org/10.1016/j.polymertesting.2018.07.015
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic QH301 Biology
spellingShingle QH301 Biology
Jaganathan, Saravana Kumar
Mani, Mohan Prasath
Nageswaran, Gomathi
Krishnasamy, Navaneetha Pandiyaraj
Ayyar, Manikandan
Single stage electrospun multicomponent scaffold for bone tissue engineering application
description Incorporation of oils in to the polymer matrix results in the improvement of physicochemical and biocompatible properties. A novel polyurethane based composite bone scaffold was fabricated by electrospinning using sunflower and neem oil for the first time. Scanning electron microscopy (SEM) revealed the mean fiber diameter of the electrospun nanocomposite was decreased with the addition of sunflower oil (816 ± 129.54 nm) and sunflower/neem oil (739 ± 130.922 nm) into the PU matrix (890 ± 116.9115 nm). The strong interactions between PU, sunflower oil and neem oil were observed through Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA). Contact angle analysis depicted the hydrophobic (PU/sunflower oil - 112° ± 1) nature and with the incorporation of neem oil it shifted to hydrophilic (PU/sunflower oil/neem oil - 61.67° ± 2.517) behavior. Further, the tensile strength analysis showed the improvement in the mechanical strength with the addition of sunflower oil (10.62 MPa) and sunflower/neem oil (11.67 MPa) in to the PU matrix (7.12 MPa). In addition, the developed composites exhibited reduced hemolytic index percentage and enhanced blood clotting time through coagulation studies. Moreover, the cytocompatibility investigation revealed the non-toxic nature of the fabricated nanocomposites with human dermal fibroblast (HDF) cells than the pristine PU. Hence, the developed PU based composites rendering better physio-chemical and cytocompatible properties can serve as an alternate substitute for bone tissue engineering applications.
format Article
author Jaganathan, Saravana Kumar
Mani, Mohan Prasath
Nageswaran, Gomathi
Krishnasamy, Navaneetha Pandiyaraj
Ayyar, Manikandan
author_facet Jaganathan, Saravana Kumar
Mani, Mohan Prasath
Nageswaran, Gomathi
Krishnasamy, Navaneetha Pandiyaraj
Ayyar, Manikandan
author_sort Jaganathan, Saravana Kumar
title Single stage electrospun multicomponent scaffold for bone tissue engineering application
title_short Single stage electrospun multicomponent scaffold for bone tissue engineering application
title_full Single stage electrospun multicomponent scaffold for bone tissue engineering application
title_fullStr Single stage electrospun multicomponent scaffold for bone tissue engineering application
title_full_unstemmed Single stage electrospun multicomponent scaffold for bone tissue engineering application
title_sort single stage electrospun multicomponent scaffold for bone tissue engineering application
publisher Elsevier Ltd
publishDate 2018
url http://eprints.utm.my/id/eprint/84571/
http://dx.doi.org/10.1016/j.polymertesting.2018.07.015
_version_ 1662754276564271104
score 13.2442

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