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Design of low molecular weight pectin and its nanoparticles through combination treatment of pectin by microwave and inorganic salts

This study examined primarily the molecular weight and degree of esterification profiles of pectin in response to treatment by microwave as a function of irradiation duration in combination with monovalent (sodium chloride) or divalent (calcium acetate) inorganic salt. The possibility of formation a...

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Main Authors: Zainudin, B. H., Wong, T. W., Hamdan, H.
Format: Article
Language:English
Published: Elsevier Ltd. 2018
Subjects:
T Technology (General)
Online Access:http://eprints.utm.my/id/eprint/83979/1/BadrulHisyamZainudin2018_DesignoflOwMolecularWeightPectin.pdf
http://eprints.utm.my/id/eprint/83979/
http://dx.doi.org/10.1016/j.polymdegradstab.2017.11.011
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spelling my.utm.839792019-11-05T04:33:42Z http://eprints.utm.my/id/eprint/83979/ Design of low molecular weight pectin and its nanoparticles through combination treatment of pectin by microwave and inorganic salts Zainudin, B. H. Wong, T. W. Hamdan, H. T Technology (General) This study examined primarily the molecular weight and degree of esterification profiles of pectin in response to treatment by microwave as a function of irradiation duration in combination with monovalent (sodium chloride) or divalent (calcium acetate) inorganic salt. The possibility of formation and physical attributes of nanoparticles prepared form these pectins were assessed against their suitability for use as nanocarrier in cancer therapy. The pectin was treated by microwave (900 W) with inorganic salts as the promoter of superheating at liquid state. Its molecular weight, degree of esterification, viscosity, particle size, zeta potential and elemental content were determined. The pectin was subjected to nanospray drying with the size, zeta potential and morphology of the formed nanoparticles examined. The use of calcium acetate translated to the formation of pectin with lower molecular weight and degree of esterification, but higher solution viscosity than that of sodium chloride. Fourier transform infrared spectroscopy, particle size and elemental content analysis indicated such pectin had its molecules crosslinked by soluble calcium at COO- moiety in liquid phase. It experienced a higher heat transfer through salt bridges and chain breakdown propensity particularly with prolonged duration of treatment. The formed nanoparticles were characterized by a mean size smaller than 600 nm and were envisaged appropriate for use as nanocarrier of cancer therapeutics with respect to permeation and retention attributes of tumour vasculature. The combination of microwave with multivalent inorganic salt is a viable approach for use to convert the pectin into matrix material of nanoparticles. Elsevier Ltd. 2018-01 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/83979/1/BadrulHisyamZainudin2018_DesignoflOwMolecularWeightPectin.pdf Zainudin, B. H. and Wong, T. W. and Hamdan, H. (2018) Design of low molecular weight pectin and its nanoparticles through combination treatment of pectin by microwave and inorganic salts. Polymer Degradation and Stability, 147 . pp. 35-40. ISSN 0141-3910 http://dx.doi.org/10.1016/j.polymdegradstab.2017.11.011 DOI:10.1016/j.polymdegradstab.2017.11.011
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic T Technology (General)
spellingShingle T Technology (General)
Zainudin, B. H.
Wong, T. W.
Hamdan, H.
Design of low molecular weight pectin and its nanoparticles through combination treatment of pectin by microwave and inorganic salts
description This study examined primarily the molecular weight and degree of esterification profiles of pectin in response to treatment by microwave as a function of irradiation duration in combination with monovalent (sodium chloride) or divalent (calcium acetate) inorganic salt. The possibility of formation and physical attributes of nanoparticles prepared form these pectins were assessed against their suitability for use as nanocarrier in cancer therapy. The pectin was treated by microwave (900 W) with inorganic salts as the promoter of superheating at liquid state. Its molecular weight, degree of esterification, viscosity, particle size, zeta potential and elemental content were determined. The pectin was subjected to nanospray drying with the size, zeta potential and morphology of the formed nanoparticles examined. The use of calcium acetate translated to the formation of pectin with lower molecular weight and degree of esterification, but higher solution viscosity than that of sodium chloride. Fourier transform infrared spectroscopy, particle size and elemental content analysis indicated such pectin had its molecules crosslinked by soluble calcium at COO- moiety in liquid phase. It experienced a higher heat transfer through salt bridges and chain breakdown propensity particularly with prolonged duration of treatment. The formed nanoparticles were characterized by a mean size smaller than 600 nm and were envisaged appropriate for use as nanocarrier of cancer therapeutics with respect to permeation and retention attributes of tumour vasculature. The combination of microwave with multivalent inorganic salt is a viable approach for use to convert the pectin into matrix material of nanoparticles.
format Article
author Zainudin, B. H.
Wong, T. W.
Hamdan, H.
author_facet Zainudin, B. H.
Wong, T. W.
Hamdan, H.
author_sort Zainudin, B. H.
title Design of low molecular weight pectin and its nanoparticles through combination treatment of pectin by microwave and inorganic salts
title_short Design of low molecular weight pectin and its nanoparticles through combination treatment of pectin by microwave and inorganic salts
title_full Design of low molecular weight pectin and its nanoparticles through combination treatment of pectin by microwave and inorganic salts
title_fullStr Design of low molecular weight pectin and its nanoparticles through combination treatment of pectin by microwave and inorganic salts
title_full_unstemmed Design of low molecular weight pectin and its nanoparticles through combination treatment of pectin by microwave and inorganic salts
title_sort design of low molecular weight pectin and its nanoparticles through combination treatment of pectin by microwave and inorganic salts
publisher Elsevier Ltd.
publishDate 2018
url http://eprints.utm.my/id/eprint/83979/1/BadrulHisyamZainudin2018_DesignoflOwMolecularWeightPectin.pdf
http://eprints.utm.my/id/eprint/83979/
http://dx.doi.org/10.1016/j.polymdegradstab.2017.11.011
_version_ 1651866743002365952
score 13.211869

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