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Bio-succinic acid production: Escherichia coli strains design from genome-scale perspectives

Escherichia coli (E. coli) has been established to be a native producer of succinic acid (a platform chemical with different applications) via mixed acid fermentation reactions. Genome-scale metabolic models (GEMs) of E. coli have been published with capabilities of predicting strain design strategi...

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Main Authors: Sajo Mienda, Bashir, Mohd. Salleh, Faezah
Format: Article
Published: 2017
Subjects:
Q Science (General)
Online Access:http://eprints.utm.my/id/eprint/81356/
http://dx.doi.org/10.3934/bioeng.2017.4.418.
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spelling my.utm.813562019-08-04T03:34:10Z http://eprints.utm.my/id/eprint/81356/ Bio-succinic acid production: Escherichia coli strains design from genome-scale perspectives Sajo Mienda, Bashir Mohd. Salleh, Faezah Q Science (General) Escherichia coli (E. coli) has been established to be a native producer of succinic acid (a platform chemical with different applications) via mixed acid fermentation reactions. Genome-scale metabolic models (GEMs) of E. coli have been published with capabilities of predicting strain design strategies for the production of bio-based succinic acid. Proof-of-principle strains are fundamentally constructed as a starting point for systems strategies for industrial strains development. Here, we review for the first time, the use of E. coli GEMs for construction of proof-of-principles strains for increasing succinic acid production. Specific case studies, where E. coli proof-of-principle strains were constructed for increasing bio-based succinic acid production from glucose and glycerol carbon sources have been highlighted. In addition, a propose systems strategies for industrial strain development that could be applicable for future microbial succinic acid production guided by GEMs have been presented. 2017 Article PeerReviewed Sajo Mienda, Bashir and Mohd. Salleh, Faezah (2017) Bio-succinic acid production: Escherichia coli strains design from genome-scale perspectives. AIMS Bioengineering, 4 (4). pp. 418-430. ISSN 2375-1495 http://dx.doi.org/10.3934/bioeng.2017.4.418. DOI:10.3934/bioeng.2017.4.418.
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic Q Science (General)
spellingShingle Q Science (General)
Sajo Mienda, Bashir
Mohd. Salleh, Faezah
Bio-succinic acid production: Escherichia coli strains design from genome-scale perspectives
description Escherichia coli (E. coli) has been established to be a native producer of succinic acid (a platform chemical with different applications) via mixed acid fermentation reactions. Genome-scale metabolic models (GEMs) of E. coli have been published with capabilities of predicting strain design strategies for the production of bio-based succinic acid. Proof-of-principle strains are fundamentally constructed as a starting point for systems strategies for industrial strains development. Here, we review for the first time, the use of E. coli GEMs for construction of proof-of-principles strains for increasing succinic acid production. Specific case studies, where E. coli proof-of-principle strains were constructed for increasing bio-based succinic acid production from glucose and glycerol carbon sources have been highlighted. In addition, a propose systems strategies for industrial strain development that could be applicable for future microbial succinic acid production guided by GEMs have been presented.
format Article
author Sajo Mienda, Bashir
Mohd. Salleh, Faezah
author_facet Sajo Mienda, Bashir
Mohd. Salleh, Faezah
author_sort Sajo Mienda, Bashir
title Bio-succinic acid production: Escherichia coli strains design from genome-scale perspectives
title_short Bio-succinic acid production: Escherichia coli strains design from genome-scale perspectives
title_full Bio-succinic acid production: Escherichia coli strains design from genome-scale perspectives
title_fullStr Bio-succinic acid production: Escherichia coli strains design from genome-scale perspectives
title_full_unstemmed Bio-succinic acid production: Escherichia coli strains design from genome-scale perspectives
title_sort bio-succinic acid production: escherichia coli strains design from genome-scale perspectives
publishDate 2017
url http://eprints.utm.my/id/eprint/81356/
http://dx.doi.org/10.3934/bioeng.2017.4.418.
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score 13.211869

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