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Effects of surfactants on antibacterial drugs - A brief review

More than half of the reported new discovered/invented drugs are ones with poor solubility, absorption or both. These are the crucial issues that can affect the bioavailability of the drugs. Therefore, improving solubility of poor-soluble drugs is absolutely important. One of the methods to solubili...

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Main Authors: Mohd. Hamzah, M. A. A., Aruldass, C. A., Ahmad, W. A., Setu, S. A.
Format: Article
Published: Penerbit UTM Press 2017
Subjects:
QA Mathematics
Online Access:http://eprints.utm.my/id/eprint/80946/
http://dx.doi.org/10.11113/mjfas.v13n2.595
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spelling my.utm.809462019-07-24T00:13:13Z http://eprints.utm.my/id/eprint/80946/ Effects of surfactants on antibacterial drugs - A brief review Mohd. Hamzah, M. A. A. Aruldass, C. A. Ahmad, W. A. Setu, S. A. QA Mathematics More than half of the reported new discovered/invented drugs are ones with poor solubility, absorption or both. These are the crucial issues that can affect the bioavailability of the drugs. Therefore, improving solubility of poor-soluble drugs is absolutely important. One of the methods to solubilize them in biological fluids is using surfactants. Surfactants are an amphiphilic organic compound containing hydrophilic and lipophilic parts that allow it to reduce the surface tension between two opposite polar phases. Several popular methods used to determine critical micelle concentration which includes surface tension, conductivity and UV-vis spectroscopy. These surfactants plays number of roles in antibacterial compound synthesis include size reduction agent, stabilizer, solubilizer and drug-carrier. This review will also critically discuss on the roles of surfactants in antibacterial compound synthesis/production and its effect on the antibacterial activity of the drugs. Penerbit UTM Press 2017 Article PeerReviewed Mohd. Hamzah, M. A. A. and Aruldass, C. A. and Ahmad, W. A. and Setu, S. A. (2017) Effects of surfactants on antibacterial drugs - A brief review. Malaysian Journal of Fundamental and Applied Sciences, 13 (2). pp. 118-123. ISSN 2289-5981 http://dx.doi.org/10.11113/mjfas.v13n2.595 DOI:10.11113/mjfas.v13n2.595
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic QA Mathematics
spellingShingle QA Mathematics
Mohd. Hamzah, M. A. A.
Aruldass, C. A.
Ahmad, W. A.
Setu, S. A.
Effects of surfactants on antibacterial drugs - A brief review
description More than half of the reported new discovered/invented drugs are ones with poor solubility, absorption or both. These are the crucial issues that can affect the bioavailability of the drugs. Therefore, improving solubility of poor-soluble drugs is absolutely important. One of the methods to solubilize them in biological fluids is using surfactants. Surfactants are an amphiphilic organic compound containing hydrophilic and lipophilic parts that allow it to reduce the surface tension between two opposite polar phases. Several popular methods used to determine critical micelle concentration which includes surface tension, conductivity and UV-vis spectroscopy. These surfactants plays number of roles in antibacterial compound synthesis include size reduction agent, stabilizer, solubilizer and drug-carrier. This review will also critically discuss on the roles of surfactants in antibacterial compound synthesis/production and its effect on the antibacterial activity of the drugs.
format Article
author Mohd. Hamzah, M. A. A.
Aruldass, C. A.
Ahmad, W. A.
Setu, S. A.
author_facet Mohd. Hamzah, M. A. A.
Aruldass, C. A.
Ahmad, W. A.
Setu, S. A.
author_sort Mohd. Hamzah, M. A. A.
title Effects of surfactants on antibacterial drugs - A brief review
title_short Effects of surfactants on antibacterial drugs - A brief review
title_full Effects of surfactants on antibacterial drugs - A brief review
title_fullStr Effects of surfactants on antibacterial drugs - A brief review
title_full_unstemmed Effects of surfactants on antibacterial drugs - A brief review
title_sort effects of surfactants on antibacterial drugs - a brief review
publisher Penerbit UTM Press
publishDate 2017
url http://eprints.utm.my/id/eprint/80946/
http://dx.doi.org/10.11113/mjfas.v13n2.595
_version_ 1643658563744169984
score 13.211869

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