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Towards gene network estimation with structure learning

Gene network is a representation of gene interactions. A gene usually collaborates with other genes in order to function. Understanding these interactions is a crucial step towards understanding how our body functions. Bayesian Network is a technique that was initially used in Expert System to rep...

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Main Authors: Zainudin, Suhaila, Deris, Safaai
Format: Conference or Workshop Item
Language:English
Published: 2006
Subjects:
QA75 Electronic computers. Computer science
Online Access:http://eprints.utm.my/id/eprint/8019/1/SafaaiDeris2006_TowardsGeneNetworkEstimationWith.pdf
http://eprints.utm.my/id/eprint/8019/
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spelling my.utm.80192010-10-12T07:07:03Z http://eprints.utm.my/id/eprint/8019/ Towards gene network estimation with structure learning Zainudin, Suhaila Deris, Safaai QA75 Electronic computers. Computer science Gene network is a representation of gene interactions. A gene usually collaborates with other genes in order to function. Understanding these interactions is a crucial step towards understanding how our body functions. Bayesian Network is a technique that was initially used in Expert System to represent expert knowledge. Since the pioneer work of Friedman et al. that applied this technique to analyse gene expression data, other researchers have enhanced the technique further. This research concentrates on enhancing Bayesian Network technique fro learning gene network. In order to get better results, Bayesian technique will be used with prior knowledge. The tool that is used to learn the gene network is PNL(Probabilistic Network Library). Early results show that PNL can be used to recover gene network for 3 subnetworks for S.Cerevisiae. These 3 subnetworks has been learned using PNL with varying success. The next step in this research is to learn the gene network from the dataset of 800 genes. The knowledge that will be gained will be used to produce a better approach to learning gene network using Bayesian network technique 2006 Conference or Workshop Item NonPeerReviewed application/pdf en http://eprints.utm.my/id/eprint/8019/1/SafaaiDeris2006_TowardsGeneNetworkEstimationWith.pdf Zainudin, Suhaila and Deris, Safaai (2006) Towards gene network estimation with structure learning. In: Proceedings of the Postgraduate Annual Research Seminar 2006 (PARS 2006), 24 - 25 May 2006, Postgraduate Studies Department FSKSM, UTM Skudai.
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic QA75 Electronic computers. Computer science
spellingShingle QA75 Electronic computers. Computer science
Zainudin, Suhaila
Deris, Safaai
Towards gene network estimation with structure learning
description Gene network is a representation of gene interactions. A gene usually collaborates with other genes in order to function. Understanding these interactions is a crucial step towards understanding how our body functions. Bayesian Network is a technique that was initially used in Expert System to represent expert knowledge. Since the pioneer work of Friedman et al. that applied this technique to analyse gene expression data, other researchers have enhanced the technique further. This research concentrates on enhancing Bayesian Network technique fro learning gene network. In order to get better results, Bayesian technique will be used with prior knowledge. The tool that is used to learn the gene network is PNL(Probabilistic Network Library). Early results show that PNL can be used to recover gene network for 3 subnetworks for S.Cerevisiae. These 3 subnetworks has been learned using PNL with varying success. The next step in this research is to learn the gene network from the dataset of 800 genes. The knowledge that will be gained will be used to produce a better approach to learning gene network using Bayesian network technique
format Conference or Workshop Item
author Zainudin, Suhaila
Deris, Safaai
author_facet Zainudin, Suhaila
Deris, Safaai
author_sort Zainudin, Suhaila
title Towards gene network estimation with structure learning
title_short Towards gene network estimation with structure learning
title_full Towards gene network estimation with structure learning
title_fullStr Towards gene network estimation with structure learning
title_full_unstemmed Towards gene network estimation with structure learning
title_sort towards gene network estimation with structure learning
publishDate 2006
url http://eprints.utm.my/id/eprint/8019/1/SafaaiDeris2006_TowardsGeneNetworkEstimationWith.pdf
http://eprints.utm.my/id/eprint/8019/
_version_ 1643644904351465472
score 13.211869

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