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Rapid Determination of Non-steroidal Anti-inflammatory Drugs in Aquatic Matrices by Two-phase Micro-electrodriven Membrane Extraction Combined with Liquid Chromatography

Two-phase micro-electrodriven membrane extraction (EME) procedure for the pre-concentration of selected non-steroidal anti-inflammatory drugs (NSAIDs) in aquatic matrices was investigated. Agarose film was used as interface between donor and acceptor phase in EME which allowed for selective extracti...

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Main Authors: Mohamad Hanapi, N. S., Sanagi, M. M., Ismail, A. K., Saim, N., Wan Ibrahim, W. N., Wan Ibrahim, W. A., Mohd Marsin, F.
Format: Article
Language:English
Published: Oxford University Press 2018
Subjects:
QD Chemistry
Online Access:http://eprints.utm.my/id/eprint/79808/1/NorSuhailaMohamadHanapi2018_RapidDeterminationofNonsteroidalAntiinflammatoryDrugs.pdf
http://eprints.utm.my/id/eprint/79808/
https://dx.doi.org/10.1093/chromsci/bmx092
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spelling my.utm.798082019-01-28T06:56:00Z http://eprints.utm.my/id/eprint/79808/ Rapid Determination of Non-steroidal Anti-inflammatory Drugs in Aquatic Matrices by Two-phase Micro-electrodriven Membrane Extraction Combined with Liquid Chromatography Mohamad Hanapi, N. S. Sanagi, M. M. Ismail, A. K. Saim, N. Wan Ibrahim, W. N. Wan Ibrahim, W. A. Mohd Marsin, F. QD Chemistry Two-phase micro-electrodriven membrane extraction (EME) procedure for the pre-concentration of selected non-steroidal anti-inflammatory drugs (NSAIDs) in aquatic matrices was investigated. Agarose film was used as interface between donor and acceptor phase in EME which allowed for selective extraction of the analytes prior to high performance liquid chromatography-ultraviolet detection. Charged analytes were transported from basic aqueous sample solution through agarose film into 1-octanol as an acceptor phase at 9 V potential. Response surface methodology in conjunction with the central composite design showed good correlations between extraction time and applied voltage (R 2 > 0.9358). Under optimized extraction conditions, the method showed good linearity in the concentration range of 0.5-500 μg L -1 with coefficients of determination, r 2 ≥ 0.9942 and good limits of detection (0.14-0.42 μg L -1) and limits of quantification (0.52-1.21 μg L -1). The results also showed high enrichment factors (62-86) and good relative recoveries (72-114%) with acceptable reproducibilities (RSDs ≤ 7.5% n = 3). The method was successfully applied to the determination of NSAIDs from tap water and river water samples. The proposed method proved to be rapid, simple and requires low voltage and minute amounts of organic solvent, thus environmentally friendly. Oxford University Press 2018-02 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/79808/1/NorSuhailaMohamadHanapi2018_RapidDeterminationofNonsteroidalAntiinflammatoryDrugs.pdf Mohamad Hanapi, N. S. and Sanagi, M. M. and Ismail, A. K. and Saim, N. and Wan Ibrahim, W. N. and Wan Ibrahim, W. A. and Mohd Marsin, F. (2018) Rapid Determination of Non-steroidal Anti-inflammatory Drugs in Aquatic Matrices by Two-phase Micro-electrodriven Membrane Extraction Combined with Liquid Chromatography. Journal of Chromatographic Science, 56 (2). pp. 166-176. ISSN 0021-9665 https://dx.doi.org/10.1093/chromsci/bmx092 DOI:10.1093/chromsci/bmx092
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Mohamad Hanapi, N. S.
Sanagi, M. M.
Ismail, A. K.
Saim, N.
Wan Ibrahim, W. N.
Wan Ibrahim, W. A.
Mohd Marsin, F.
Rapid Determination of Non-steroidal Anti-inflammatory Drugs in Aquatic Matrices by Two-phase Micro-electrodriven Membrane Extraction Combined with Liquid Chromatography
description Two-phase micro-electrodriven membrane extraction (EME) procedure for the pre-concentration of selected non-steroidal anti-inflammatory drugs (NSAIDs) in aquatic matrices was investigated. Agarose film was used as interface between donor and acceptor phase in EME which allowed for selective extraction of the analytes prior to high performance liquid chromatography-ultraviolet detection. Charged analytes were transported from basic aqueous sample solution through agarose film into 1-octanol as an acceptor phase at 9 V potential. Response surface methodology in conjunction with the central composite design showed good correlations between extraction time and applied voltage (R 2 > 0.9358). Under optimized extraction conditions, the method showed good linearity in the concentration range of 0.5-500 μg L -1 with coefficients of determination, r 2 ≥ 0.9942 and good limits of detection (0.14-0.42 μg L -1) and limits of quantification (0.52-1.21 μg L -1). The results also showed high enrichment factors (62-86) and good relative recoveries (72-114%) with acceptable reproducibilities (RSDs ≤ 7.5% n = 3). The method was successfully applied to the determination of NSAIDs from tap water and river water samples. The proposed method proved to be rapid, simple and requires low voltage and minute amounts of organic solvent, thus environmentally friendly.
format Article
author Mohamad Hanapi, N. S.
Sanagi, M. M.
Ismail, A. K.
Saim, N.
Wan Ibrahim, W. N.
Wan Ibrahim, W. A.
Mohd Marsin, F.
author_facet Mohamad Hanapi, N. S.
Sanagi, M. M.
Ismail, A. K.
Saim, N.
Wan Ibrahim, W. N.
Wan Ibrahim, W. A.
Mohd Marsin, F.
author_sort Mohamad Hanapi, N. S.
title Rapid Determination of Non-steroidal Anti-inflammatory Drugs in Aquatic Matrices by Two-phase Micro-electrodriven Membrane Extraction Combined with Liquid Chromatography
title_short Rapid Determination of Non-steroidal Anti-inflammatory Drugs in Aquatic Matrices by Two-phase Micro-electrodriven Membrane Extraction Combined with Liquid Chromatography
title_full Rapid Determination of Non-steroidal Anti-inflammatory Drugs in Aquatic Matrices by Two-phase Micro-electrodriven Membrane Extraction Combined with Liquid Chromatography
title_fullStr Rapid Determination of Non-steroidal Anti-inflammatory Drugs in Aquatic Matrices by Two-phase Micro-electrodriven Membrane Extraction Combined with Liquid Chromatography
title_full_unstemmed Rapid Determination of Non-steroidal Anti-inflammatory Drugs in Aquatic Matrices by Two-phase Micro-electrodriven Membrane Extraction Combined with Liquid Chromatography
title_sort rapid determination of non-steroidal anti-inflammatory drugs in aquatic matrices by two-phase micro-electrodriven membrane extraction combined with liquid chromatography
publisher Oxford University Press
publishDate 2018
url http://eprints.utm.my/id/eprint/79808/1/NorSuhailaMohamadHanapi2018_RapidDeterminationofNonsteroidalAntiinflammatoryDrugs.pdf
http://eprints.utm.my/id/eprint/79808/
https://dx.doi.org/10.1093/chromsci/bmx092
_version_ 1643658299518746624
score 13.211869

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