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Anti-tyrosinase and cytotoxic activities of synthetic compound 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone

It has been demonstrated by several studies that synthetic chalcone compound products having antioxidant and anti tyrosinase properties. In this study, the novel synthetic 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone (HTMC) was evaluated for their antityrosinase, antioxidant, and cytotoxicity propertie...

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Main Author: Ahmad, Nor Azlina
Format: Thesis
Language:English
Published: 2012
Subjects:
TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/78309/1/NorAzlinaAhmadMFBB20121.pdf
http://eprints.utm.my/id/eprint/78309/
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spelling my.utm.783092018-08-20T07:25:27Z http://eprints.utm.my/id/eprint/78309/ Anti-tyrosinase and cytotoxic activities of synthetic compound 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone Ahmad, Nor Azlina TP Chemical technology It has been demonstrated by several studies that synthetic chalcone compound products having antioxidant and anti tyrosinase properties. In this study, the novel synthetic 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone (HTMC) was evaluated for their antityrosinase, antioxidant, and cytotoxicity properties. In anti tyrosinase activities, HTMC showed an activity and is postulated as potential tyrosinase inhibitor. The antityrosinase activity of HTMC, however, was lower than Kojic Acid (positive control). It was due to the structure of HTMC that have been modified synthetically at position 4 by inserting methoxy group. For that reason, the potency of HTMC as tyrosinase inhibitor was reduced and this statement supports our finding that is HTMC have less active compared to kojic acid. In contrast, HTMC demonstrate low antioxidant activities for both DPPH and FRAP assays. The highest percentage of inhibition for HTMC was 37% in DPPH assay at the concentration of 242 μM whilst the highest FRAP value of HTMC was 2 351 μmol/L. It is due to their chemical structure that contains only 1 group of hydroxyl in A-ring at position 2 that reflected to its ability to scavenge free radicals. HTMC showed negligible toxicity effect on Chinese Hamster Ovary (CHO) cell at the concentration of (0, 0.01, 0.1 and 1) μM. As it considered as preliminary report on cytotoxicity effect of HTMC, this data is valuable to be further investigated on human cell line. 2012 Thesis NonPeerReviewed application/pdf en http://eprints.utm.my/id/eprint/78309/1/NorAzlinaAhmadMFBB20121.pdf Ahmad, Nor Azlina (2012) Anti-tyrosinase and cytotoxic activities of synthetic compound 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone. Masters thesis, Universiti Teknologi Malaysia, Faculty of Biosciences and Medical Engineering. http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:82609
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Ahmad, Nor Azlina
Anti-tyrosinase and cytotoxic activities of synthetic compound 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone
description It has been demonstrated by several studies that synthetic chalcone compound products having antioxidant and anti tyrosinase properties. In this study, the novel synthetic 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone (HTMC) was evaluated for their antityrosinase, antioxidant, and cytotoxicity properties. In anti tyrosinase activities, HTMC showed an activity and is postulated as potential tyrosinase inhibitor. The antityrosinase activity of HTMC, however, was lower than Kojic Acid (positive control). It was due to the structure of HTMC that have been modified synthetically at position 4 by inserting methoxy group. For that reason, the potency of HTMC as tyrosinase inhibitor was reduced and this statement supports our finding that is HTMC have less active compared to kojic acid. In contrast, HTMC demonstrate low antioxidant activities for both DPPH and FRAP assays. The highest percentage of inhibition for HTMC was 37% in DPPH assay at the concentration of 242 μM whilst the highest FRAP value of HTMC was 2 351 μmol/L. It is due to their chemical structure that contains only 1 group of hydroxyl in A-ring at position 2 that reflected to its ability to scavenge free radicals. HTMC showed negligible toxicity effect on Chinese Hamster Ovary (CHO) cell at the concentration of (0, 0.01, 0.1 and 1) μM. As it considered as preliminary report on cytotoxicity effect of HTMC, this data is valuable to be further investigated on human cell line.
format Thesis
author Ahmad, Nor Azlina
author_facet Ahmad, Nor Azlina
author_sort Ahmad, Nor Azlina
title Anti-tyrosinase and cytotoxic activities of synthetic compound 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone
title_short Anti-tyrosinase and cytotoxic activities of synthetic compound 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone
title_full Anti-tyrosinase and cytotoxic activities of synthetic compound 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone
title_fullStr Anti-tyrosinase and cytotoxic activities of synthetic compound 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone
title_full_unstemmed Anti-tyrosinase and cytotoxic activities of synthetic compound 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone
title_sort anti-tyrosinase and cytotoxic activities of synthetic compound 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone
publishDate 2012
url http://eprints.utm.my/id/eprint/78309/1/NorAzlinaAhmadMFBB20121.pdf
http://eprints.utm.my/id/eprint/78309/
http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:82609
_version_ 1643657859064397824
score 13.211869

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