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Preparation, characterization and biocompatibility evaluation of poly(diol citrate) blend polyethersulfone hemodialysis membranes

Hemodialysis is one of the applied membrane technologies that is regarded as a life-saving therapy for patients with impaired kidneys. It purifies blood toxins outside of the patient’s body using a dialyzer as a kidney replacement. Synthetic materials such as polyethersulfone (PES) polymer are curre...

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Main Author: Zailani, Muhamad Zulhilmi
Format: Thesis
Language:English
Published: 2017
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TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/78234/1/MuhamadZulhilmiZailaniMFChE2017.pdf
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spelling my.utm.782342018-07-30T08:51:31Z http://eprints.utm.my/id/eprint/78234/ Preparation, characterization and biocompatibility evaluation of poly(diol citrate) blend polyethersulfone hemodialysis membranes Zailani, Muhamad Zulhilmi TP Chemical technology Hemodialysis is one of the applied membrane technologies that is regarded as a life-saving therapy for patients with impaired kidneys. It purifies blood toxins outside of the patient’s body using a dialyzer as a kidney replacement. Synthetic materials such as polyethersulfone (PES) polymer are currently being used to fabricate the dialyzer membrane for hemodialysis. However, the blood compatibility or hemocompatibility of these materials are still inadequate and administration of an anticoagulant (heparin) is required throughout the dialysis procedure to avoid blood clotting. Therefore this study aimed at developing a biocompatibility membrane for hemodialysis application. In this study, poly (1,8-octanediol citrate) (POC) that synthesized through a simple polycondesation method was used to enhance membrane biocompatibility. Different compositions of POC (0-3%) were added into polyethersulfone (PES) dope solutions to fabricate modified biocompatible PES membranes via the phase-inversion technique. The biocompatibility of the modified PES membranes was evaluated by human serum fibrinogen (FBG) protein adsorption, platelet adhesion, activated partial thromboplastin time (APTT) and prothrombin time (PT), thrombin–antithrombin III (TAT), complement (C3a and C5a) activation and Ca2+ absorption on membrane. Results showed that higher POC wt.% caused a 31% reduction of FBG adsorption, less platelets adhesion, prolonged APTT (11.1 seconds) and PT (2.5 seconds), lower TAT activation, suppressed C5a and C3a activation and absorbed 35% more Ca2+ ion compared to pristine PES membrane. These results indicated that modified PES blended POC has good biocompatibility properties, suggesting potential application in the field of blood purification, especially in hemodialysis. 2017-01 Thesis NonPeerReviewed application/pdf en http://eprints.utm.my/id/eprint/78234/1/MuhamadZulhilmiZailaniMFChE2017.pdf Zailani, Muhamad Zulhilmi (2017) Preparation, characterization and biocompatibility evaluation of poly(diol citrate) blend polyethersulfone hemodialysis membranes. Masters thesis, Universiti Teknologi Malaysia, Faculty of Chemical Engineering. http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:105050
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Zailani, Muhamad Zulhilmi
Preparation, characterization and biocompatibility evaluation of poly(diol citrate) blend polyethersulfone hemodialysis membranes
description Hemodialysis is one of the applied membrane technologies that is regarded as a life-saving therapy for patients with impaired kidneys. It purifies blood toxins outside of the patient’s body using a dialyzer as a kidney replacement. Synthetic materials such as polyethersulfone (PES) polymer are currently being used to fabricate the dialyzer membrane for hemodialysis. However, the blood compatibility or hemocompatibility of these materials are still inadequate and administration of an anticoagulant (heparin) is required throughout the dialysis procedure to avoid blood clotting. Therefore this study aimed at developing a biocompatibility membrane for hemodialysis application. In this study, poly (1,8-octanediol citrate) (POC) that synthesized through a simple polycondesation method was used to enhance membrane biocompatibility. Different compositions of POC (0-3%) were added into polyethersulfone (PES) dope solutions to fabricate modified biocompatible PES membranes via the phase-inversion technique. The biocompatibility of the modified PES membranes was evaluated by human serum fibrinogen (FBG) protein adsorption, platelet adhesion, activated partial thromboplastin time (APTT) and prothrombin time (PT), thrombin–antithrombin III (TAT), complement (C3a and C5a) activation and Ca2+ absorption on membrane. Results showed that higher POC wt.% caused a 31% reduction of FBG adsorption, less platelets adhesion, prolonged APTT (11.1 seconds) and PT (2.5 seconds), lower TAT activation, suppressed C5a and C3a activation and absorbed 35% more Ca2+ ion compared to pristine PES membrane. These results indicated that modified PES blended POC has good biocompatibility properties, suggesting potential application in the field of blood purification, especially in hemodialysis.
format Thesis
author Zailani, Muhamad Zulhilmi
author_facet Zailani, Muhamad Zulhilmi
author_sort Zailani, Muhamad Zulhilmi
title Preparation, characterization and biocompatibility evaluation of poly(diol citrate) blend polyethersulfone hemodialysis membranes
title_short Preparation, characterization and biocompatibility evaluation of poly(diol citrate) blend polyethersulfone hemodialysis membranes
title_full Preparation, characterization and biocompatibility evaluation of poly(diol citrate) blend polyethersulfone hemodialysis membranes
title_fullStr Preparation, characterization and biocompatibility evaluation of poly(diol citrate) blend polyethersulfone hemodialysis membranes
title_full_unstemmed Preparation, characterization and biocompatibility evaluation of poly(diol citrate) blend polyethersulfone hemodialysis membranes
title_sort preparation, characterization and biocompatibility evaluation of poly(diol citrate) blend polyethersulfone hemodialysis membranes
publishDate 2017
url http://eprints.utm.my/id/eprint/78234/1/MuhamadZulhilmiZailaniMFChE2017.pdf
http://eprints.utm.my/id/eprint/78234/
http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:105050
_version_ 1643657835966365696
score 13.211869

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