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Gold nanodisc arrays as near infrared metal-enhanced fluorescence platforms with tuneable enhancement factors

Metal enhanced fluorescence (MEF) is a physical effect through which the near-field interaction of fluorophores with metallic nanoparticles can lead to large fluorescence enhancement. MEF can be exploited in many fluorescence-based biomedical applications, with potentially significant improvement in...

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Main Authors: Pang, J., Theodorou, I. G., Centeno, A., Petrov, P. K., Alford, N. M., Ryan, M. P., Xie, F.
Format: Article
Published: The Royal Society of Chemistry 2017
Subjects:
T Technology (General)
Online Access:http://eprints.utm.my/id/eprint/77474/
http://dx.doi.org/10.1039/c6tc04965f
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spelling my.utm.774742018-11-30T07:09:45Z http://eprints.utm.my/id/eprint/77474/ Gold nanodisc arrays as near infrared metal-enhanced fluorescence platforms with tuneable enhancement factors Pang, J. Theodorou, I. G. Centeno, A. Petrov, P. K. Alford, N. M. Ryan, M. P. Xie, F. T Technology (General) Metal enhanced fluorescence (MEF) is a physical effect through which the near-field interaction of fluorophores with metallic nanoparticles can lead to large fluorescence enhancement. MEF can be exploited in many fluorescence-based biomedical applications, with potentially significant improvement in detection sensitivity and contrast enhancement. Offering lower autofluorescence and minimal photoinduced damage, the development of effective and multifunctional MEF platforms in the near-infrared (NIR) region, is particularly desirable. In this work, the enhancement of NIR fluorescence caused by interaction with regular arrays of cylindrical gold (Au) nanoparticles (nanodiscs), fabricated through nanosphere lithography, is reported. Significant MEF of up to 235 times is obtained, with tuneable enhancement factors. The effect of array structure on fluorescence enhancement is investigated by semi-quantitatively de-convoluting excitation enhancement from emission enhancement, and modelling the local electric field enhancement. By considering arrays of Au nanodiscs with the same extinction maximum, it is shown that the excitation enhancement, due to increased electric field, is not significantly different for the particle sizes and separation distances considered. Rather, it is seen that the emission from the fluorophore is strongly enhanced, and is dependent on the topography, in particular particle size. The results show that the structural characteristics of Au nanodisc arrays can be manipulated to tune their enhancement factor, and hence their sensitivity. The Royal Society of Chemistry 2017 Article PeerReviewed Pang, J. and Theodorou, I. G. and Centeno, A. and Petrov, P. K. and Alford, N. M. and Ryan, M. P. and Xie, F. (2017) Gold nanodisc arrays as near infrared metal-enhanced fluorescence platforms with tuneable enhancement factors. Journal of Materials Chemistry C, 5 (4). pp. 917-925. ISSN 2050-7534 http://dx.doi.org/10.1039/c6tc04965f DOI: 10.1039/c6tc04965f
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic T Technology (General)
spellingShingle T Technology (General)
Pang, J.
Theodorou, I. G.
Centeno, A.
Petrov, P. K.
Alford, N. M.
Ryan, M. P.
Xie, F.
Gold nanodisc arrays as near infrared metal-enhanced fluorescence platforms with tuneable enhancement factors
description Metal enhanced fluorescence (MEF) is a physical effect through which the near-field interaction of fluorophores with metallic nanoparticles can lead to large fluorescence enhancement. MEF can be exploited in many fluorescence-based biomedical applications, with potentially significant improvement in detection sensitivity and contrast enhancement. Offering lower autofluorescence and minimal photoinduced damage, the development of effective and multifunctional MEF platforms in the near-infrared (NIR) region, is particularly desirable. In this work, the enhancement of NIR fluorescence caused by interaction with regular arrays of cylindrical gold (Au) nanoparticles (nanodiscs), fabricated through nanosphere lithography, is reported. Significant MEF of up to 235 times is obtained, with tuneable enhancement factors. The effect of array structure on fluorescence enhancement is investigated by semi-quantitatively de-convoluting excitation enhancement from emission enhancement, and modelling the local electric field enhancement. By considering arrays of Au nanodiscs with the same extinction maximum, it is shown that the excitation enhancement, due to increased electric field, is not significantly different for the particle sizes and separation distances considered. Rather, it is seen that the emission from the fluorophore is strongly enhanced, and is dependent on the topography, in particular particle size. The results show that the structural characteristics of Au nanodisc arrays can be manipulated to tune their enhancement factor, and hence their sensitivity.
format Article
author Pang, J.
Theodorou, I. G.
Centeno, A.
Petrov, P. K.
Alford, N. M.
Ryan, M. P.
Xie, F.
author_facet Pang, J.
Theodorou, I. G.
Centeno, A.
Petrov, P. K.
Alford, N. M.
Ryan, M. P.
Xie, F.
author_sort Pang, J.
title Gold nanodisc arrays as near infrared metal-enhanced fluorescence platforms with tuneable enhancement factors
title_short Gold nanodisc arrays as near infrared metal-enhanced fluorescence platforms with tuneable enhancement factors
title_full Gold nanodisc arrays as near infrared metal-enhanced fluorescence platforms with tuneable enhancement factors
title_fullStr Gold nanodisc arrays as near infrared metal-enhanced fluorescence platforms with tuneable enhancement factors
title_full_unstemmed Gold nanodisc arrays as near infrared metal-enhanced fluorescence platforms with tuneable enhancement factors
title_sort gold nanodisc arrays as near infrared metal-enhanced fluorescence platforms with tuneable enhancement factors
publisher The Royal Society of Chemistry
publishDate 2017
url http://eprints.utm.my/id/eprint/77474/
http://dx.doi.org/10.1039/c6tc04965f
_version_ 1643657562562756608
score 13.211869

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