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NMR-based metabolomics Reveals Alterations of Electro-acupuncture Stimulations on Chronic Atrophic Gastritis Rats

Chronic atrophic gastritis (CAG) is a common gastrointestinal disease which has been considered as precancerous lesions of gastric carcinoma. Previously, electro-acupuncture stimulation has been shown to be effective in ameliorating symptoms of CAG. However the underlying mechanism of this beneficia...

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Main Authors: Xu, Jingjing, Zheng, Xujuan, Cheng, Kian Kai, Chang, Xiaorong, Shen, Guiping, Liu, Mi, Wang, Yadong, Shen, Jiacheng, Zhang, Yuan, He, Qida, Dong, Jiyang, Yang, Zongbao
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Published: Nature Publishing Group 2017
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TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/77431/
https://www.nature.com/articles/srep45580.pdf
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spelling my.utm.774312018-06-29T22:25:34Z http://eprints.utm.my/id/eprint/77431/ NMR-based metabolomics Reveals Alterations of Electro-acupuncture Stimulations on Chronic Atrophic Gastritis Rats Xu, Jingjing Zheng, Xujuan Cheng, Kian Kai Chang, Xiaorong Shen, Guiping Liu, Mi Wang, Yadong Shen, Jiacheng Zhang, Yuan He, Qida Dong, Jiyang Yang, Zongbao TP Chemical technology Chronic atrophic gastritis (CAG) is a common gastrointestinal disease which has been considered as precancerous lesions of gastric carcinoma. Previously, electro-acupuncture stimulation has been shown to be effective in ameliorating symptoms of CAG. However the underlying mechanism of this beneficial treatment is yet to be established. In the present study, an integrated histopathological examination along with molecular biological assay, as well as 1H NMR analysis of multiple biological samples (urine, serum, stomach, cortex and medulla) were employed to systematically assess the pathology of CAG and therapeutic effect of electro-acupuncture stimulation at Sibai (ST 2), Liangmen (ST 21), and Zusanli (ST 36) acupoints located in the stomach meridian using a rat model of CAG. The current results showed that CAG caused comprehensive metabolic alterations including the TCA cycle, glycolysis, membrane metabolism and catabolism, gut microbiota-related metabolism. On the other hand, electro-acupuncture treatment was found able to normalize a number of CAG-induced metabolomics changes by alleviating membrane catabolism, restoring function of neurotransmitter in brain and partially reverse the CAG-induced perturbation in gut microbiota metabolism. These findings provided new insights into the biochemistry of CAG and mechanism of the therapeutic effect of electro-acupuncture stimulations. Nature Publishing Group 2017 Article PeerReviewed Xu, Jingjing and Zheng, Xujuan and Cheng, Kian Kai and Chang, Xiaorong and Shen, Guiping and Liu, Mi and Wang, Yadong and Shen, Jiacheng and Zhang, Yuan and He, Qida and Dong, Jiyang and Yang, Zongbao (2017) NMR-based metabolomics Reveals Alterations of Electro-acupuncture Stimulations on Chronic Atrophic Gastritis Rats. Scientific Reports, 7 (45580). pp. 1-12. ISSN 2045-2322 https://www.nature.com/articles/srep45580.pdf
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic TP Chemical technology
spellingShingle TP Chemical technology
Xu, Jingjing
Zheng, Xujuan
Cheng, Kian Kai
Chang, Xiaorong
Shen, Guiping
Liu, Mi
Wang, Yadong
Shen, Jiacheng
Zhang, Yuan
He, Qida
Dong, Jiyang
Yang, Zongbao
NMR-based metabolomics Reveals Alterations of Electro-acupuncture Stimulations on Chronic Atrophic Gastritis Rats
description Chronic atrophic gastritis (CAG) is a common gastrointestinal disease which has been considered as precancerous lesions of gastric carcinoma. Previously, electro-acupuncture stimulation has been shown to be effective in ameliorating symptoms of CAG. However the underlying mechanism of this beneficial treatment is yet to be established. In the present study, an integrated histopathological examination along with molecular biological assay, as well as 1H NMR analysis of multiple biological samples (urine, serum, stomach, cortex and medulla) were employed to systematically assess the pathology of CAG and therapeutic effect of electro-acupuncture stimulation at Sibai (ST 2), Liangmen (ST 21), and Zusanli (ST 36) acupoints located in the stomach meridian using a rat model of CAG. The current results showed that CAG caused comprehensive metabolic alterations including the TCA cycle, glycolysis, membrane metabolism and catabolism, gut microbiota-related metabolism. On the other hand, electro-acupuncture treatment was found able to normalize a number of CAG-induced metabolomics changes by alleviating membrane catabolism, restoring function of neurotransmitter in brain and partially reverse the CAG-induced perturbation in gut microbiota metabolism. These findings provided new insights into the biochemistry of CAG and mechanism of the therapeutic effect of electro-acupuncture stimulations.
format Article
author Xu, Jingjing
Zheng, Xujuan
Cheng, Kian Kai
Chang, Xiaorong
Shen, Guiping
Liu, Mi
Wang, Yadong
Shen, Jiacheng
Zhang, Yuan
He, Qida
Dong, Jiyang
Yang, Zongbao
author_facet Xu, Jingjing
Zheng, Xujuan
Cheng, Kian Kai
Chang, Xiaorong
Shen, Guiping
Liu, Mi
Wang, Yadong
Shen, Jiacheng
Zhang, Yuan
He, Qida
Dong, Jiyang
Yang, Zongbao
author_sort Xu, Jingjing
title NMR-based metabolomics Reveals Alterations of Electro-acupuncture Stimulations on Chronic Atrophic Gastritis Rats
title_short NMR-based metabolomics Reveals Alterations of Electro-acupuncture Stimulations on Chronic Atrophic Gastritis Rats
title_full NMR-based metabolomics Reveals Alterations of Electro-acupuncture Stimulations on Chronic Atrophic Gastritis Rats
title_fullStr NMR-based metabolomics Reveals Alterations of Electro-acupuncture Stimulations on Chronic Atrophic Gastritis Rats
title_full_unstemmed NMR-based metabolomics Reveals Alterations of Electro-acupuncture Stimulations on Chronic Atrophic Gastritis Rats
title_sort nmr-based metabolomics reveals alterations of electro-acupuncture stimulations on chronic atrophic gastritis rats
publisher Nature Publishing Group
publishDate 2017
url http://eprints.utm.my/id/eprint/77431/
https://www.nature.com/articles/srep45580.pdf
_version_ 1643657559019618304
score 13.211869

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