Flavonoids from the leaves and heartwoods of Artocarpus lowii King and their bioactivities
A new dihydrochalcone, 2′,4′-dihydroxy-3,4-(2″,2″-dimethylchromeno)-3′-prenyldihydrochalcone (1) together with 4-hydroxyonchocarpin (2), isobavachalcone (3), 4′,5-dihydroxy-6,7-(2,2-dimethylpyrano)-2′-methoxy-8-γ,γ-dimethylallyflavone (4), artocarpin (5) and cycloheterophyllin (6) were successfully...
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2017
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my.utm.769852018-05-31T09:33:06Z http://eprints.utm.my/id/eprint/76985/ Flavonoids from the leaves and heartwoods of Artocarpus lowii King and their bioactivities Abdullah, S. A. Jamil, S. Basar, N. Abdul Lathiff, S. M. Mohd. Arriffin, N. QD Chemistry A new dihydrochalcone, 2′,4′-dihydroxy-3,4-(2″,2″-dimethylchromeno)-3′-prenyldihydrochalcone (1) together with 4-hydroxyonchocarpin (2), isobavachalcone (3), 4′,5-dihydroxy-6,7-(2,2-dimethylpyrano)-2′-methoxy-8-γ,γ-dimethylallyflavone (4), artocarpin (5) and cycloheterophyllin (6) were successfully isolated from the leaves and heartwoods of Artocarpus lowii King (Moraceae). The structures of these compounds were fully characterised using spectroscopic methods and by direct comparison with published data. These compounds were tested for their antioxidant and tyrosinase inhibitory activities. Compound (1) displayed moderate antioxidant activity towards DPPH and tyrosinase inhibitory activities with SC50value of 223.8 μM and IC50value of 722.5 μM, respectively. Among the isolated compounds, cycloheterophyllin (6) showed the most potential antioxidant activity with SC50value of 320.0 and 102.8 μM for ABTS and DPPH radicals scavenging activities, respectively, and also exhibited highest FRAP equivalent value of 4.7 ± 0.09 mM. Compound (6) showed tyrosinase inhibitory activity with the IC50value of 104.6 μM. Taylor and Francis Ltd. 2017 Article PeerReviewed Abdullah, S. A. and Jamil, S. and Basar, N. and Abdul Lathiff, S. M. and Mohd. Arriffin, N. (2017) Flavonoids from the leaves and heartwoods of Artocarpus lowii King and their bioactivities. Natural Product Research, 31 (10). pp. 1113-1120. ISSN 1478-6419 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983746016&doi=10.1080%2f14786419.2016.1222387&partnerID=40&md5=18dc6f0f5c128a5972f80ae4ea08298c DOI:10.1080/14786419.2016.1222387 |
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QD Chemistry Abdullah, S. A. Jamil, S. Basar, N. Abdul Lathiff, S. M. Mohd. Arriffin, N. Flavonoids from the leaves and heartwoods of Artocarpus lowii King and their bioactivities |
| description |
A new dihydrochalcone, 2′,4′-dihydroxy-3,4-(2″,2″-dimethylchromeno)-3′-prenyldihydrochalcone (1) together with 4-hydroxyonchocarpin (2), isobavachalcone (3), 4′,5-dihydroxy-6,7-(2,2-dimethylpyrano)-2′-methoxy-8-γ,γ-dimethylallyflavone (4), artocarpin (5) and cycloheterophyllin (6) were successfully isolated from the leaves and heartwoods of Artocarpus lowii King (Moraceae). The structures of these compounds were fully characterised using spectroscopic methods and by direct comparison with published data. These compounds were tested for their antioxidant and tyrosinase inhibitory activities. Compound (1) displayed moderate antioxidant activity towards DPPH and tyrosinase inhibitory activities with SC50value of 223.8 μM and IC50value of 722.5 μM, respectively. Among the isolated compounds, cycloheterophyllin (6) showed the most potential antioxidant activity with SC50value of 320.0 and 102.8 μM for ABTS and DPPH radicals scavenging activities, respectively, and also exhibited highest FRAP equivalent value of 4.7 ± 0.09 mM. Compound (6) showed tyrosinase inhibitory activity with the IC50value of 104.6 μM. |
| format |
Article |
| author |
Abdullah, S. A. Jamil, S. Basar, N. Abdul Lathiff, S. M. Mohd. Arriffin, N. |
| author_facet |
Abdullah, S. A. Jamil, S. Basar, N. Abdul Lathiff, S. M. Mohd. Arriffin, N. |
| author_sort |
Abdullah, S. A. |
| title |
Flavonoids from the leaves and heartwoods of Artocarpus lowii King and their bioactivities |
| title_short |
Flavonoids from the leaves and heartwoods of Artocarpus lowii King and their bioactivities |
| title_full |
Flavonoids from the leaves and heartwoods of Artocarpus lowii King and their bioactivities |
| title_fullStr |
Flavonoids from the leaves and heartwoods of Artocarpus lowii King and their bioactivities |
| title_full_unstemmed |
Flavonoids from the leaves and heartwoods of Artocarpus lowii King and their bioactivities |
| title_sort |
flavonoids from the leaves and heartwoods of artocarpus lowii king and their bioactivities |
| publisher |
Taylor and Francis Ltd. |
| publishDate |
2017 |
| url |
http://eprints.utm.my/id/eprint/76985/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983746016&doi=10.1080%2f14786419.2016.1222387&partnerID=40&md5=18dc6f0f5c128a5972f80ae4ea08298c |
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1643657465491881984 |
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13.211869 |