Drug delivery and cytocompatibility of ciprofloxacin loaded gelatin nanofibers-coated Mg alloy
In this study, gelatin-ciprofloxacin (Gel-Cip) nanofibers containing various amounts of Cip (0, 2, 4 and, 8 wt%) were fabricated on the surface of Mg-1Ca alloy via an electrospinning process. Microscopic characterization indicated a porous network structure with fiber diameters in the range of 150–1...
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| Main Authors: | , , , , , |
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| Format: | Article |
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Elsevier B.V.
2017
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| Subjects: | |
| Online Access: | http://eprints.utm.my/id/eprint/76925/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025088109&doi=10.1016%2fj.matlet.2017.07.072&partnerID=40&md5=59192b2ca088ba08e3b117e46b3158a0 |
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| Summary: | In this study, gelatin-ciprofloxacin (Gel-Cip) nanofibers containing various amounts of Cip (0, 2, 4 and, 8 wt%) were fabricated on the surface of Mg-1Ca alloy via an electrospinning process. Microscopic characterization indicated a porous network structure with fiber diameters in the range of 150–170 nm. Prolonged drug release was attained from Gel-Cip nanofibers coating along with initial rapid drug release of around 20–22% during 12 h, followed by a slow release stage that can effectively control the infection. The incorporation of 2–4 wt% Cip into Gel nanofibers coating significantly increased the antibacterial performance and corrosion resistance of the uncoated Mg-Ca alloy without showing an inhibitory influence on the cytocompatibility characteristic. Hence, it is potentially appropriate as the novel electrospun nanofibers coating material for bone regeneration application. |
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