Staff View: Phytochemicals and biological activities of Macaranga hosei and Macaranga constricta (Euphorbiaceae)

Phytochemicals and biological activities of Macaranga hosei and Macaranga constricta (Euphorbiaceae)

Phytochemicals and biological activities of the leaves of Macaranga hosei and Macaranga constricta have been studied. Fractionation and purification of the extracts of M. hosei afforded two triterpenoids, lupenone (1) and β-sitostenone (2) and two flavonoids, 5-hydroxy-7,4’-dimethoxyflavone (3) and...

Full description

Saved in:

Bibliographic Details
Main Authors:	Salleh, W. M. N. H. W., Razak, N. Z. A., Ahmad, F.
Format:	Article
Published:	Marmara University 2017
Subjects:	QD Chemistry
Online Access:	http://eprints.utm.my/id/eprint/76912/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-85031401972&doi=10.12991%2fmpj.2017.11&partnerID=40&md5=17fbeaafda26acb5e12f1c5478eace72
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my.utm.76912
record_format	eprints
spelling	my.utm.769122018-04-30T14:25:47Z http://eprints.utm.my/id/eprint/76912/ Phytochemicals and biological activities of Macaranga hosei and Macaranga constricta (Euphorbiaceae) Salleh, W. M. N. H. W. Razak, N. Z. A. Ahmad, F. QD Chemistry Phytochemicals and biological activities of the leaves of Macaranga hosei and Macaranga constricta have been studied. Fractionation and purification of the extracts of M. hosei afforded two triterpenoids, lupenone (1) and β-sitostenone (2) and two flavonoids, 5-hydroxy-7,4’-dimethoxyflavone (3) and 5-hydroxy-6,7,4’-trimethoxyflavone (4). Three triterpenoids characterized as taraxerone (5), taraxerol (6) and β-amyrin (7) were isolated from M. constricta. The structures of these compounds were established by analysis of their spectroscopic data, as compared to that of reported compounds. Biological activities which include antibacterial, α-glucosidase inhibition and antioxidant were also carried out. The antibacterial activities have demonstrated that all extracts and isolated compounds exhibited weak inhibition against the tested bacterial strains with MIC value exceeded 500 μg/mL. Evaluation of α-glucosidase inhibition activity using ρ-nitrophenyl-ρ-D-glucopyranosidase on extracts exhibited α-glucosidase inhibitory potential. The most potent α-glucosidase activity was exhibited by the petroleum ether extract of M. hosei with inhibitory concentration at 50% (IC50) of 25.3 ppm compared with quercetin (4.5 ppm) and acarbose (12.6 ppm). The antioxidant activity was conducted through DPPH radical scavenging activity and total phenolic content. All the extracts displayed positive results and the methanol extract of M. hosei displayed the highest scavenging activity with scavenging concentration at 50% (SC50) value of 25.8 ppm. The methanol extract of M. hosei also gave the highest total phenol content with 347.7 mg GAE/g. Marmara University 2017 Article PeerReviewed Salleh, W. M. N. H. W. and Razak, N. Z. A. and Ahmad, F. (2017) Phytochemicals and biological activities of Macaranga hosei and Macaranga constricta (Euphorbiaceae). Marmara Pharmaceutical Journal, 21 (4). pp. 881-888. ISSN 1309-0801 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85031401972&doi=10.12991%2fmpj.2017.11&partnerID=40&md5=17fbeaafda26acb5e12f1c5478eace72 DOI:10.12991/mpj.2017.11
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
topic	QD Chemistry
spellingShingle	QD Chemistry Salleh, W. M. N. H. W. Razak, N. Z. A. Ahmad, F. Phytochemicals and biological activities of Macaranga hosei and Macaranga constricta (Euphorbiaceae)
description	Phytochemicals and biological activities of the leaves of Macaranga hosei and Macaranga constricta have been studied. Fractionation and purification of the extracts of M. hosei afforded two triterpenoids, lupenone (1) and β-sitostenone (2) and two flavonoids, 5-hydroxy-7,4’-dimethoxyflavone (3) and 5-hydroxy-6,7,4’-trimethoxyflavone (4). Three triterpenoids characterized as taraxerone (5), taraxerol (6) and β-amyrin (7) were isolated from M. constricta. The structures of these compounds were established by analysis of their spectroscopic data, as compared to that of reported compounds. Biological activities which include antibacterial, α-glucosidase inhibition and antioxidant were also carried out. The antibacterial activities have demonstrated that all extracts and isolated compounds exhibited weak inhibition against the tested bacterial strains with MIC value exceeded 500 μg/mL. Evaluation of α-glucosidase inhibition activity using ρ-nitrophenyl-ρ-D-glucopyranosidase on extracts exhibited α-glucosidase inhibitory potential. The most potent α-glucosidase activity was exhibited by the petroleum ether extract of M. hosei with inhibitory concentration at 50% (IC50) of 25.3 ppm compared with quercetin (4.5 ppm) and acarbose (12.6 ppm). The antioxidant activity was conducted through DPPH radical scavenging activity and total phenolic content. All the extracts displayed positive results and the methanol extract of M. hosei displayed the highest scavenging activity with scavenging concentration at 50% (SC50) value of 25.8 ppm. The methanol extract of M. hosei also gave the highest total phenol content with 347.7 mg GAE/g.
format	Article
author	Salleh, W. M. N. H. W. Razak, N. Z. A. Ahmad, F.
author_facet	Salleh, W. M. N. H. W. Razak, N. Z. A. Ahmad, F.
author_sort	Salleh, W. M. N. H. W.
title	Phytochemicals and biological activities of Macaranga hosei and Macaranga constricta (Euphorbiaceae)
title_short	Phytochemicals and biological activities of Macaranga hosei and Macaranga constricta (Euphorbiaceae)
title_full	Phytochemicals and biological activities of Macaranga hosei and Macaranga constricta (Euphorbiaceae)
title_fullStr	Phytochemicals and biological activities of Macaranga hosei and Macaranga constricta (Euphorbiaceae)
title_full_unstemmed	Phytochemicals and biological activities of Macaranga hosei and Macaranga constricta (Euphorbiaceae)
title_sort	phytochemicals and biological activities of macaranga hosei and macaranga constricta (euphorbiaceae)
publisher	Marmara University
publishDate	2017
url	http://eprints.utm.my/id/eprint/76912/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-85031401972&doi=10.12991%2fmpj.2017.11&partnerID=40&md5=17fbeaafda26acb5e12f1c5478eace72
_version_	1643657445803819008
score	13.211869

Phytochemicals and biological activities of Macaranga hosei and Macaranga constricta (Euphorbiaceae)

Similar Items