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Adsorption and desorption of curcumin by poly(vinyl) alcohol-multiwalled carbon nanotubes (PVA-MWCNT)

Carbon nanotubes (CNT) are among the most striking discoveries in the search for new materials as drug delivery carrier. In the present work, multiwalled CNT (MWCNT) functionalized with polyvinyl alcohol (PVA) was developed as a potential carrier for Curcumin (Cur). The aim was to investigate its lo...

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Main Authors: Zawawi, N. A., Majid, Z. A., Rashid, N. A. A.
Format: Article
Published: Springer Verlag 2017
Subjects:
QD Chemistry
Online Access:http://eprints.utm.my/id/eprint/75935/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85026909427&doi=10.1007%2fs00396-017-4163-0&partnerID=40&md5=26f4a30efb84822d2040ed6bf1fd31a9
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spelling my.utm.759352018-05-30T04:11:18Z http://eprints.utm.my/id/eprint/75935/ Adsorption and desorption of curcumin by poly(vinyl) alcohol-multiwalled carbon nanotubes (PVA-MWCNT) Zawawi, N. A. Majid, Z. A. Rashid, N. A. A. QD Chemistry Carbon nanotubes (CNT) are among the most striking discoveries in the search for new materials as drug delivery carrier. In the present work, multiwalled CNT (MWCNT) functionalized with polyvinyl alcohol (PVA) was developed as a potential carrier for Curcumin (Cur). The aim was to investigate its loading and release efficiency in vitro. To achieve this goal, pristine MWCNT (p-MWCNT) was firstly oxidized by acids and functionalized with PVA. Next, systematic evaluation of Cur loading efficiency on PVA-MWCNT was determined using adsorption kinetics and isotherm studies and was compared to p-MWCNT and oxidized-MWCNT (ox-MWCNT). The release of Cur was analyzed in physiological buffer pH 7.4 and 5.5. From the results, all MWCNT adsorbed Cur rapidly and well described by the pseudo-second order model. The isotherm results suggest that the PVA-MWCNT and p-MWCNT obey Freundlich isotherm model with maximum Cur adsorption (kf) of 5.1 and 69.0 mg/g, respectively, while Cur adsorption on ox-MWCNT followed Langmuir isotherm model with maximum adsorption (qm) of 714.3 mg/g. Cur desorbed significantly (25–30%) from PVA-MWCNT at pH 5.5 than that of pH 7.4, with a sustained release over 3 days of incubation. The results suggest its weak binding interaction to the PVA-MWCNT has facilitated its release at lower pH, compared to ox-MWCNT that occurred via chemisorption. The p-MWCNT ranked the lowest with 4–6% Cur released at both pHs. Overall, the initially developed drug delivery system was considered successful for loading and the release of Cur, which potentially benefit disorders related to cancer or oxidative-related injuries in the future. Springer Verlag 2017 Article PeerReviewed Zawawi, N. A. and Majid, Z. A. and Rashid, N. A. A. (2017) Adsorption and desorption of curcumin by poly(vinyl) alcohol-multiwalled carbon nanotubes (PVA-MWCNT). Colloid and Polymer Science, 295 (10). pp. 1925-1936. ISSN 0303-402X https://www.scopus.com/inward/record.uri?eid=2-s2.0-85026909427&doi=10.1007%2fs00396-017-4163-0&partnerID=40&md5=26f4a30efb84822d2040ed6bf1fd31a9
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic QD Chemistry
spellingShingle QD Chemistry
Zawawi, N. A.
Majid, Z. A.
Rashid, N. A. A.
Adsorption and desorption of curcumin by poly(vinyl) alcohol-multiwalled carbon nanotubes (PVA-MWCNT)
description Carbon nanotubes (CNT) are among the most striking discoveries in the search for new materials as drug delivery carrier. In the present work, multiwalled CNT (MWCNT) functionalized with polyvinyl alcohol (PVA) was developed as a potential carrier for Curcumin (Cur). The aim was to investigate its loading and release efficiency in vitro. To achieve this goal, pristine MWCNT (p-MWCNT) was firstly oxidized by acids and functionalized with PVA. Next, systematic evaluation of Cur loading efficiency on PVA-MWCNT was determined using adsorption kinetics and isotherm studies and was compared to p-MWCNT and oxidized-MWCNT (ox-MWCNT). The release of Cur was analyzed in physiological buffer pH 7.4 and 5.5. From the results, all MWCNT adsorbed Cur rapidly and well described by the pseudo-second order model. The isotherm results suggest that the PVA-MWCNT and p-MWCNT obey Freundlich isotherm model with maximum Cur adsorption (kf) of 5.1 and 69.0 mg/g, respectively, while Cur adsorption on ox-MWCNT followed Langmuir isotherm model with maximum adsorption (qm) of 714.3 mg/g. Cur desorbed significantly (25–30%) from PVA-MWCNT at pH 5.5 than that of pH 7.4, with a sustained release over 3 days of incubation. The results suggest its weak binding interaction to the PVA-MWCNT has facilitated its release at lower pH, compared to ox-MWCNT that occurred via chemisorption. The p-MWCNT ranked the lowest with 4–6% Cur released at both pHs. Overall, the initially developed drug delivery system was considered successful for loading and the release of Cur, which potentially benefit disorders related to cancer or oxidative-related injuries in the future.
format Article
author Zawawi, N. A.
Majid, Z. A.
Rashid, N. A. A.
author_facet Zawawi, N. A.
Majid, Z. A.
Rashid, N. A. A.
author_sort Zawawi, N. A.
title Adsorption and desorption of curcumin by poly(vinyl) alcohol-multiwalled carbon nanotubes (PVA-MWCNT)
title_short Adsorption and desorption of curcumin by poly(vinyl) alcohol-multiwalled carbon nanotubes (PVA-MWCNT)
title_full Adsorption and desorption of curcumin by poly(vinyl) alcohol-multiwalled carbon nanotubes (PVA-MWCNT)
title_fullStr Adsorption and desorption of curcumin by poly(vinyl) alcohol-multiwalled carbon nanotubes (PVA-MWCNT)
title_full_unstemmed Adsorption and desorption of curcumin by poly(vinyl) alcohol-multiwalled carbon nanotubes (PVA-MWCNT)
title_sort adsorption and desorption of curcumin by poly(vinyl) alcohol-multiwalled carbon nanotubes (pva-mwcnt)
publisher Springer Verlag
publishDate 2017
url http://eprints.utm.my/id/eprint/75935/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85026909427&doi=10.1007%2fs00396-017-4163-0&partnerID=40&md5=26f4a30efb84822d2040ed6bf1fd31a9
_version_ 1643657201212981248
score 13.211869

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