Synthesis of pyrano2,3-cpyrazoles by ionic liquids under green and eco-safe conditions
Optimization of a green approach to the synthesis of pyrano[2,3-c]pyrazoles based on the one-pot, four-component condensation via a domino Knoevenagel/Michael/cyclization sequence was investigated. This method involved the evaluation of the activity of several ionic liquids (ILs) in various solvents...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Published: |
Springer Netherlands
2017
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| Subjects: | |
| Online Access: | http://eprints.utm.my/id/eprint/75733/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-84979256984&doi=10.1007%2fs11164-016-2648-y&partnerID=40&md5=e4f2e267df9ab2c41ec1ccf500a587fe |
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| Summary: | Optimization of a green approach to the synthesis of pyrano[2,3-c]pyrazoles based on the one-pot, four-component condensation via a domino Knoevenagel/Michael/cyclization sequence was investigated. This method involved the evaluation of the activity of several ionic liquids (ILs) in various solvents. This one-pot, four-component reaction revealed simplicity, higher yield and lower toxicity advantages over a corresponding three-component method. The effect of reaction parameters including the type and amount of catalyst, type of solvent, reaction temperature and time were studied with respect to yield of pyrano[2,3-c]pyrazoles. Catalyst recyclability and time-saving aspects of the reaction suggest that this method presents real alternatives over conventional reaction protocols. |
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