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Metabolomics, lipidomics and pharmacometabolomics of human hypertension

Hypertension is a common but complex human disease, which can lead to a heart attack, stroke, kidney disease or other complications. Since the pathogenesis of hypertension is heterogeneous and multifactorial, it is crucial to establish a comprehensive metabolomic approach to elucidate the molecular...

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Main Authors: Au, A., Cheng, K. K., Wei, L. K.
Format: Book Section
Published: Springer New York LLC 2017
Subjects:
TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/74819/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019191365&doi=10.1007%2f5584_2016_79&partnerID=40&md5=e2e555410fda3a18e2f93ed2bba2d60f
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spelling my.utm.748192017-11-28T08:38:31Z http://eprints.utm.my/id/eprint/74819/ Metabolomics, lipidomics and pharmacometabolomics of human hypertension Au, A. Cheng, K. K. Wei, L. K. TP Chemical technology Hypertension is a common but complex human disease, which can lead to a heart attack, stroke, kidney disease or other complications. Since the pathogenesis of hypertension is heterogeneous and multifactorial, it is crucial to establish a comprehensive metabolomic approach to elucidate the molecular mechanism of hypertension. Although there have been limited metabolomic, lipidomic and pharmacometabolomic studies investigating this disease to date, metabolomic studies on hypertension have provided greater insights into the identification of disease-specific biomarkers, predicting treatment outcome and monitor drug safety and efficacy. Therefore, we discuss recent updates on the applications of metabolomics technology in human hypertension with a focus on metabolic biomarker discovery. Springer New York LLC 2017 Book Section PeerReviewed Au, A. and Cheng, K. K. and Wei, L. K. (2017) Metabolomics, lipidomics and pharmacometabolomics of human hypertension. In: Advances in Experimental Medicine and Biology. Springer New York LLC, pp. 599-613. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019191365&doi=10.1007%2f5584_2016_79&partnerID=40&md5=e2e555410fda3a18e2f93ed2bba2d60f
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic TP Chemical technology
spellingShingle TP Chemical technology
Au, A.
Cheng, K. K.
Wei, L. K.
Metabolomics, lipidomics and pharmacometabolomics of human hypertension
description Hypertension is a common but complex human disease, which can lead to a heart attack, stroke, kidney disease or other complications. Since the pathogenesis of hypertension is heterogeneous and multifactorial, it is crucial to establish a comprehensive metabolomic approach to elucidate the molecular mechanism of hypertension. Although there have been limited metabolomic, lipidomic and pharmacometabolomic studies investigating this disease to date, metabolomic studies on hypertension have provided greater insights into the identification of disease-specific biomarkers, predicting treatment outcome and monitor drug safety and efficacy. Therefore, we discuss recent updates on the applications of metabolomics technology in human hypertension with a focus on metabolic biomarker discovery.
format Book Section
author Au, A.
Cheng, K. K.
Wei, L. K.
author_facet Au, A.
Cheng, K. K.
Wei, L. K.
author_sort Au, A.
title Metabolomics, lipidomics and pharmacometabolomics of human hypertension
title_short Metabolomics, lipidomics and pharmacometabolomics of human hypertension
title_full Metabolomics, lipidomics and pharmacometabolomics of human hypertension
title_fullStr Metabolomics, lipidomics and pharmacometabolomics of human hypertension
title_full_unstemmed Metabolomics, lipidomics and pharmacometabolomics of human hypertension
title_sort metabolomics, lipidomics and pharmacometabolomics of human hypertension
publisher Springer New York LLC
publishDate 2017
url http://eprints.utm.my/id/eprint/74819/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019191365&doi=10.1007%2f5584_2016_79&partnerID=40&md5=e2e555410fda3a18e2f93ed2bba2d60f
_version_ 1643656946804326400
score 13.211869

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