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In vitro permeation and skin retention of a-mangostin proniosome

The current investigation evaluated the potential of proniosome as a carrier to enhance skin permeation and skin retention of a highly lipophilic compound, α-mangostin. α-Mangostin proniosomes were prepared using the coacervation phase seperation method. Upon hydration, α-mangostin loaded niosomes w...

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Main Authors: Chin, G. S., Todo, H., Kadhum, W. R., Hamid, M. A., Sugibayashi, K.
Format: Article
Published: Pharmaceutical Society of Japan 2016
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TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/74446/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85000842886&doi=10.1248%2fcpb.c16-00425&partnerID=40&md5=f0e35ee9a9bbbf02fd85d550cf437d25
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spelling my.utm.744462017-11-29T23:58:37Z http://eprints.utm.my/id/eprint/74446/ In vitro permeation and skin retention of a-mangostin proniosome Chin, G. S. Todo, H. Kadhum, W. R. Hamid, M. A. Sugibayashi, K. TP Chemical technology The current investigation evaluated the potential of proniosome as a carrier to enhance skin permeation and skin retention of a highly lipophilic compound, α-mangostin. α-Mangostin proniosomes were prepared using the coacervation phase seperation method. Upon hydration, α-mangostin loaded niosomes were characterized for size, polydispersity index (PDI), entrapment efficiency (EE) and ζ-potential. The in vitro permeation experiments with dermis-split Yucatan Micropig (YMP) skin revealed that proniosomes composed of Spans, soya lecithin and cholesterol were able to enhance the skin permeation of α-mangostin with a factor range from 1.8- to 8.0-fold as compared to the control suspension. Furthermore, incorporation of soya lecithin in the proniosomal formulation significantly enhanced the viable epidermis/dermis (VED) concentration of α-mangostin. All the proniosomal formulations (except for S20L) had significantly (p<0.05) enhanced deposition of α-mangostin in the VED layer with a factor range from 2.5- to 2.9-fold as compared to the control suspension. Since addition of Spans and soya lecithin in water improved the solubility of α-mangostin, this would be related to the enhancement of skin permeation and skin concentration of α-mangostin. The choice of non-ionic surfactant in proniosomes is an important factor governing the skin permeation and skin retention of α-mangostin. These results suggested that proniosomes can be utilized as a carrier for highly lipophilic compound like α-mangostin for topical application. Pharmaceutical Society of Japan 2016 Article PeerReviewed Chin, G. S. and Todo, H. and Kadhum, W. R. and Hamid, M. A. and Sugibayashi, K. (2016) In vitro permeation and skin retention of a-mangostin proniosome. Chemical and Pharmaceutical Bulletin, 64 (12). pp. 1666-1673. ISSN 0009-2363 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85000842886&doi=10.1248%2fcpb.c16-00425&partnerID=40&md5=f0e35ee9a9bbbf02fd85d550cf437d25
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic TP Chemical technology
spellingShingle TP Chemical technology
Chin, G. S.
Todo, H.
Kadhum, W. R.
Hamid, M. A.
Sugibayashi, K.
In vitro permeation and skin retention of a-mangostin proniosome
description The current investigation evaluated the potential of proniosome as a carrier to enhance skin permeation and skin retention of a highly lipophilic compound, α-mangostin. α-Mangostin proniosomes were prepared using the coacervation phase seperation method. Upon hydration, α-mangostin loaded niosomes were characterized for size, polydispersity index (PDI), entrapment efficiency (EE) and ζ-potential. The in vitro permeation experiments with dermis-split Yucatan Micropig (YMP) skin revealed that proniosomes composed of Spans, soya lecithin and cholesterol were able to enhance the skin permeation of α-mangostin with a factor range from 1.8- to 8.0-fold as compared to the control suspension. Furthermore, incorporation of soya lecithin in the proniosomal formulation significantly enhanced the viable epidermis/dermis (VED) concentration of α-mangostin. All the proniosomal formulations (except for S20L) had significantly (p<0.05) enhanced deposition of α-mangostin in the VED layer with a factor range from 2.5- to 2.9-fold as compared to the control suspension. Since addition of Spans and soya lecithin in water improved the solubility of α-mangostin, this would be related to the enhancement of skin permeation and skin concentration of α-mangostin. The choice of non-ionic surfactant in proniosomes is an important factor governing the skin permeation and skin retention of α-mangostin. These results suggested that proniosomes can be utilized as a carrier for highly lipophilic compound like α-mangostin for topical application.
format Article
author Chin, G. S.
Todo, H.
Kadhum, W. R.
Hamid, M. A.
Sugibayashi, K.
author_facet Chin, G. S.
Todo, H.
Kadhum, W. R.
Hamid, M. A.
Sugibayashi, K.
author_sort Chin, G. S.
title In vitro permeation and skin retention of a-mangostin proniosome
title_short In vitro permeation and skin retention of a-mangostin proniosome
title_full In vitro permeation and skin retention of a-mangostin proniosome
title_fullStr In vitro permeation and skin retention of a-mangostin proniosome
title_full_unstemmed In vitro permeation and skin retention of a-mangostin proniosome
title_sort in vitro permeation and skin retention of a-mangostin proniosome
publisher Pharmaceutical Society of Japan
publishDate 2016
url http://eprints.utm.my/id/eprint/74446/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85000842886&doi=10.1248%2fcpb.c16-00425&partnerID=40&md5=f0e35ee9a9bbbf02fd85d550cf437d25
_version_ 1643656858523664384
score 13.211869

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