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A simulation study of single cell inside an integrated dual nanoneedle-microfludic system

Electrical properties of living cells have been proven to play significant roles in understanding of various biological activities including disease progression both at the cellular and molecular levels. Analyzing the cell’s electrical states especially in single cell analysis (SCA) lead to differen...

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Main Authors: Mansor, M. A., Ahmad, M. R.
Format: Article
Language:English
Published: Penerbit UTM Press 2016
Subjects:
TK Electrical engineering. Electronics Nuclear engineering
Online Access:http://eprints.utm.my/id/eprint/74445/1/MuhammdAsrafMansor2016_ASimulationStudyofSingleCell.pdf
http://eprints.utm.my/id/eprint/74445/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84979711129&doi=10.11113%2fjt.v78.9451&partnerID=40&md5=6ec804e5509852f7fc331827d40791a4
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spelling my.utm.744452017-11-27T09:02:13Z http://eprints.utm.my/id/eprint/74445/ A simulation study of single cell inside an integrated dual nanoneedle-microfludic system Mansor, M. A. Ahmad, M. R. TK Electrical engineering. Electronics Nuclear engineering Electrical properties of living cells have been proven to play significant roles in understanding of various biological activities including disease progression both at the cellular and molecular levels. Analyzing the cell’s electrical states especially in single cell analysis (SCA) lead to differentiate between normal cell and cancer cell. This paper presents a simulation study of micro-channel and nanoneedle structure, fluid manipulation and current flow through HeLa cell inside a microfluidic channel. To perform electrical measurement, gold dual nanoneedle has been utilized. The simulation result revealed, the cell penetration occurs at microchannel dimension and solution flow rate is 22 µm x 70 µm x 25 µm (width x length x height) and 0.396 pL/min, respectively. The purposed device has capability to characterize the electrical property of single cells can be used as a novel method for cell viability detection in instantaneous manner. Penerbit UTM Press 2016 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/74445/1/MuhammdAsrafMansor2016_ASimulationStudyofSingleCell.pdf Mansor, M. A. and Ahmad, M. R. (2016) A simulation study of single cell inside an integrated dual nanoneedle-microfludic system. Jurnal Teknologi, 78 (7-5). pp. 59-65. ISSN 0127-9696 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84979711129&doi=10.11113%2fjt.v78.9451&partnerID=40&md5=6ec804e5509852f7fc331827d40791a4
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic TK Electrical engineering. Electronics Nuclear engineering
spellingShingle TK Electrical engineering. Electronics Nuclear engineering
Mansor, M. A.
Ahmad, M. R.
A simulation study of single cell inside an integrated dual nanoneedle-microfludic system
description Electrical properties of living cells have been proven to play significant roles in understanding of various biological activities including disease progression both at the cellular and molecular levels. Analyzing the cell’s electrical states especially in single cell analysis (SCA) lead to differentiate between normal cell and cancer cell. This paper presents a simulation study of micro-channel and nanoneedle structure, fluid manipulation and current flow through HeLa cell inside a microfluidic channel. To perform electrical measurement, gold dual nanoneedle has been utilized. The simulation result revealed, the cell penetration occurs at microchannel dimension and solution flow rate is 22 µm x 70 µm x 25 µm (width x length x height) and 0.396 pL/min, respectively. The purposed device has capability to characterize the electrical property of single cells can be used as a novel method for cell viability detection in instantaneous manner.
format Article
author Mansor, M. A.
Ahmad, M. R.
author_facet Mansor, M. A.
Ahmad, M. R.
author_sort Mansor, M. A.
title A simulation study of single cell inside an integrated dual nanoneedle-microfludic system
title_short A simulation study of single cell inside an integrated dual nanoneedle-microfludic system
title_full A simulation study of single cell inside an integrated dual nanoneedle-microfludic system
title_fullStr A simulation study of single cell inside an integrated dual nanoneedle-microfludic system
title_full_unstemmed A simulation study of single cell inside an integrated dual nanoneedle-microfludic system
title_sort simulation study of single cell inside an integrated dual nanoneedle-microfludic system
publisher Penerbit UTM Press
publishDate 2016
url http://eprints.utm.my/id/eprint/74445/1/MuhammdAsrafMansor2016_ASimulationStudyofSingleCell.pdf
http://eprints.utm.my/id/eprint/74445/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84979711129&doi=10.11113%2fjt.v78.9451&partnerID=40&md5=6ec804e5509852f7fc331827d40791a4
_version_ 1643656858231111680
score 13.211869

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