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Microwave-assisted synthesis of mesoporous silica nanoparticles as a drug delivery vehicle

Nanotechnology has been utilized in medicine for therapeutic drug delivery and the development of treatments for a variety of diseases and disorders. Mesoporous silica nanoparticles (MSN), which combine both unique properties of nanomaterials and mesostructured substances, have aroused special atten...

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Main Authors: Kamarudin, N. H. N., Jalil, A. A., Triwahyono, S., Timmiati, S. N.
Format: Article
Published: Malaysian Society of Analytical Sciences 2016
Subjects:
TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/74377/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85003583746&doi=10.17576%2fmjas-2016-2006-17&partnerID=40&md5=ed47579f7da1f42f6d425be256cdf369
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spelling my.utm.743772017-11-29T23:58:39Z http://eprints.utm.my/id/eprint/74377/ Microwave-assisted synthesis of mesoporous silica nanoparticles as a drug delivery vehicle Kamarudin, N. H. N. Jalil, A. A. Triwahyono, S. Timmiati, S. N. TP Chemical technology Nanotechnology has been utilized in medicine for therapeutic drug delivery and the development of treatments for a variety of diseases and disorders. Mesoporous silica nanoparticles (MSN), which combine both unique properties of nanomaterials and mesostructured substances, have aroused special attention in biomedical research field due to its great advantages in many aspects such as well biocompatible, unique properties of tunable pore size and structure, large surface areas and pore volumes, controllable morphology and modifiable surfaces, high chemical and thermal stabilities. In this study, the microwave was utilized to synthesize MSN under 100 W, 300 W and 450 W heating powers. All MSNs was tested for adsorption and release of an anti-inflammatory and anti-cancer drug, ibuprofen. The characterization revealed that the MSN prepared under 450 W (MSN450) produced the most ordered and prominent mesoporous structure compared to lower power applied. MSN450 exhibited the highest ibuprofen adsorption, followed by MSN300 and MSN100, confirming that more ordered MSN demonstrated higher adsorptivity toward ibuprofen. For the release study, MSN450 showed the slowest release rate of ibuprofen, followed by MSN300 and MSN100. All MSNs was found to exhibit good activity for the ibuprofen adsorption and release. Malaysian Society of Analytical Sciences 2016 Article PeerReviewed Kamarudin, N. H. N. and Jalil, A. A. and Triwahyono, S. and Timmiati, S. N. (2016) Microwave-assisted synthesis of mesoporous silica nanoparticles as a drug delivery vehicle. Malaysian Journal of Analytical Sciences, 20 (6). pp. 1382-1389. ISSN 1394-2506 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85003583746&doi=10.17576%2fmjas-2016-2006-17&partnerID=40&md5=ed47579f7da1f42f6d425be256cdf369
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic TP Chemical technology
spellingShingle TP Chemical technology
Kamarudin, N. H. N.
Jalil, A. A.
Triwahyono, S.
Timmiati, S. N.
Microwave-assisted synthesis of mesoporous silica nanoparticles as a drug delivery vehicle
description Nanotechnology has been utilized in medicine for therapeutic drug delivery and the development of treatments for a variety of diseases and disorders. Mesoporous silica nanoparticles (MSN), which combine both unique properties of nanomaterials and mesostructured substances, have aroused special attention in biomedical research field due to its great advantages in many aspects such as well biocompatible, unique properties of tunable pore size and structure, large surface areas and pore volumes, controllable morphology and modifiable surfaces, high chemical and thermal stabilities. In this study, the microwave was utilized to synthesize MSN under 100 W, 300 W and 450 W heating powers. All MSNs was tested for adsorption and release of an anti-inflammatory and anti-cancer drug, ibuprofen. The characterization revealed that the MSN prepared under 450 W (MSN450) produced the most ordered and prominent mesoporous structure compared to lower power applied. MSN450 exhibited the highest ibuprofen adsorption, followed by MSN300 and MSN100, confirming that more ordered MSN demonstrated higher adsorptivity toward ibuprofen. For the release study, MSN450 showed the slowest release rate of ibuprofen, followed by MSN300 and MSN100. All MSNs was found to exhibit good activity for the ibuprofen adsorption and release.
format Article
author Kamarudin, N. H. N.
Jalil, A. A.
Triwahyono, S.
Timmiati, S. N.
author_facet Kamarudin, N. H. N.
Jalil, A. A.
Triwahyono, S.
Timmiati, S. N.
author_sort Kamarudin, N. H. N.
title Microwave-assisted synthesis of mesoporous silica nanoparticles as a drug delivery vehicle
title_short Microwave-assisted synthesis of mesoporous silica nanoparticles as a drug delivery vehicle
title_full Microwave-assisted synthesis of mesoporous silica nanoparticles as a drug delivery vehicle
title_fullStr Microwave-assisted synthesis of mesoporous silica nanoparticles as a drug delivery vehicle
title_full_unstemmed Microwave-assisted synthesis of mesoporous silica nanoparticles as a drug delivery vehicle
title_sort microwave-assisted synthesis of mesoporous silica nanoparticles as a drug delivery vehicle
publisher Malaysian Society of Analytical Sciences
publishDate 2016
url http://eprints.utm.my/id/eprint/74377/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85003583746&doi=10.17576%2fmjas-2016-2006-17&partnerID=40&md5=ed47579f7da1f42f6d425be256cdf369
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score 13.222552

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