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Beilschglabrines A and B: two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra

Two new phenanthrene alkaloids, beilschglabrines A (1) and B (2) were isolated from the stem bark of Beilschmiedia glabra, together with lupeol, taraxerol, and 24-methylenelanosta-7,9-diene-3β-15α-diol. The structures of the isolated compounds were elucidated by extensive spectroscopic data analysis...

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Main Authors:	Salleh, W. M. N. H. W., Ahmad, F., Khong, H. Y., Zulkifli, R. M., Chen, J. J., Nahar, L., Wansi, J. D., Sarker, S. D.
Format:	Article
Published:	Elsevier Ltd 2016
Subjects:	QD Chemistry
Online Access:	http://eprints.utm.my/id/eprint/72504/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964659720&doi=10.1016%2fj.phytol.2016.04.013&partnerID=40&md5=a2975f6d81f2211ef8bf44d5de8f5799
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spelling	my.utm.725042017-11-27T00:30:26Z http://eprints.utm.my/id/eprint/72504/ Beilschglabrines A and B: two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra Salleh, W. M. N. H. W. Ahmad, F. Khong, H. Y. Zulkifli, R. M. Chen, J. J. Nahar, L. Wansi, J. D. Sarker, S. D. QD Chemistry Two new phenanthrene alkaloids, beilschglabrines A (1) and B (2) were isolated from the stem bark of Beilschmiedia glabra, together with lupeol, taraxerol, and 24-methylenelanosta-7,9-diene-3β-15α-diol. The structures of the isolated compounds were elucidated by extensive spectroscopic data analysis and comparison with respective literature data. The compounds were tested for DPPH radical scavenging, acetylcholinesterase and lipoxygenase inhibitory activities. Compound 1 displayed considerable activity in the acetylcholinesterase (IC50 50.4 μM), the DPPH radical scavenging (IC50 115.9 μM) and the lipoxygenase (IC50 32.8 μM) assays. Elsevier Ltd 2016 Article PeerReviewed Salleh, W. M. N. H. W. and Ahmad, F. and Khong, H. Y. and Zulkifli, R. M. and Chen, J. J. and Nahar, L. and Wansi, J. D. and Sarker, S. D. (2016) Beilschglabrines A and B: two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra. Phytochemistry Letters, 16 . pp. 192-196. ISSN 1874-3900 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964659720&doi=10.1016%2fj.phytol.2016.04.013&partnerID=40&md5=a2975f6d81f2211ef8bf44d5de8f5799
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
topic	QD Chemistry
spellingShingle	QD Chemistry Salleh, W. M. N. H. W. Ahmad, F. Khong, H. Y. Zulkifli, R. M. Chen, J. J. Nahar, L. Wansi, J. D. Sarker, S. D. Beilschglabrines A and B: two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra
description	Two new phenanthrene alkaloids, beilschglabrines A (1) and B (2) were isolated from the stem bark of Beilschmiedia glabra, together with lupeol, taraxerol, and 24-methylenelanosta-7,9-diene-3β-15α-diol. The structures of the isolated compounds were elucidated by extensive spectroscopic data analysis and comparison with respective literature data. The compounds were tested for DPPH radical scavenging, acetylcholinesterase and lipoxygenase inhibitory activities. Compound 1 displayed considerable activity in the acetylcholinesterase (IC50 50.4 μM), the DPPH radical scavenging (IC50 115.9 μM) and the lipoxygenase (IC50 32.8 μM) assays.
format	Article
author	Salleh, W. M. N. H. W. Ahmad, F. Khong, H. Y. Zulkifli, R. M. Chen, J. J. Nahar, L. Wansi, J. D. Sarker, S. D.
author_facet	Salleh, W. M. N. H. W. Ahmad, F. Khong, H. Y. Zulkifli, R. M. Chen, J. J. Nahar, L. Wansi, J. D. Sarker, S. D.
author_sort	Salleh, W. M. N. H. W.
title	Beilschglabrines A and B: two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra
title_short	Beilschglabrines A and B: two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra
title_full	Beilschglabrines A and B: two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra
title_fullStr	Beilschglabrines A and B: two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra
title_full_unstemmed	Beilschglabrines A and B: two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra
title_sort	beilschglabrines a and b: two new bioactive phenanthrene alkaloids from the stem bark of beilschmiedia glabra
publisher	Elsevier Ltd
publishDate	2016
url	http://eprints.utm.my/id/eprint/72504/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964659720&doi=10.1016%2fj.phytol.2016.04.013&partnerID=40&md5=a2975f6d81f2211ef8bf44d5de8f5799
_version_	1643656458318905344
score	13.211869

Beilschglabrines A and B: two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra

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